Understanding how the immune system destroys dangerous cells
Grant number: 1029295 | Funding period: 2012 - 2014
The immune system is the essential complex barrier that protects the organism for infections and some malignancies. Despite considerable efforts, the mechanism by which immune cells kill dangerous unwanted cells is poorly understood. This project will investigate the mechanism of action and the role in human pathologies of a key component of the immune system, a toxic protein perforin.
Related publications (1)
Defining the interaction of perforin with calcium and the phospholipid membrane
Daouda AK Traore, Amelia J Brennan, Ruby HP Law, Con Dogovski, Matthew A Perugini, Natalya Lukoyanova, Eleanor WW Leung, Raymond S Norton, Jamie A Lopez, Kylie A Browne, Hideo Yagita, Gordon J Lloyd, Annette Ciccone, Sandra Verschoor, Joseph A Trapani, James C Whisstock, Ilia Voskoboinik