Promoting Axonal Connectivity Of Transplanted Neurons In Parkinson'S Disease

Grant number: 1022637 | Funding period: 2012 - 2014

Completed

Abstract

Many obstacles exist for cell transplantation in ParkinsonÍs Disease; namely poor graft survival, restoration of appropriate circuitry and adequate nerve fiber growth from new cells. Using knowledge of how neural circuits are established during fetal development, we will attempt to recapitulate these events following transplantation. Further, we will identify new and novel cues in regulating the connectivity and growth of these nerve fibers.