Self-Reactivity by NKT Cells

Grant number: 1021972 | Funding period: 2012 - 2014

Completed

Abstract

NKT cells are a type of lymphocyte with the ability to prevent a broad range of diseases including cancer, autoimmunity, infection and graft rejection. Sometimes, NKT cells also cause diseases, including allergy and atherosclerosis. This project will investigate how NKT cells become activated in these diseases by studying their surface receptors and what these receptors interact with.

Related publications (8)

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Antigen specificity of type i NKT cells is governed by TCR β-chain diversity

G Cameron, DG Pellicci, AP Uldrich, GS Besra, P Illarionov, SJ Williams, NL La Gruta, J Rossjohn, DI Godfrey

2015-11-15

NKT cells recognize lipid-based Ags presented by CD1d. Type I NKT cells are often referred to as invariant owing to their mostly i..

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Identification of a potent microbial lipid antigen for diverse NKT cells

BJ Wolf, RVV Tatituri, CF Almeida, J Le Nours, V Bhowruth, D Johnson, AP Uldrich, FF Hsu, M Brigl, GS Besra, J Rossjohn, DI Godfrey, MB Brenner

2015-09-15

Semi-invariant/type I NKT cells are a well-characterized CD1d-restricted T cell subset. The availability of potent Ags and tetrame..

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NKT cells: The smoking gun in fungal-induced asthma?

DI Godfrey, DG Pellicci, J Rossjohn

2013-10-01

Aspergillus fumigatus is a fungus that is associated with a severe form of asthma, although the precise immunological basis for th..

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Natural Killer T cell obsession with self-antigens

L Gapin, DI Godfrey, J Rossjohn

2013-04-01

Natural Killer T (NKT) cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical Major H..

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CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells

JP Sanderson, PJ Brennan, S Mansour, G Matulis, O Patel, N Lissin, DI Godfrey, K Kawahara, U Zähringer, J Rossjohn, MB Brenner, SD Gadola

2013-03-01

Isoglobotrihexosylceramide (iGb3) has been identified as a potent CD1d-presented self-antigen for mouse invariant natural killer T..

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Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs

RVV Tatituri, GFM Watts, V Bhowruth, N Barton, A Rothchild, FF Hsu, CF Almeida, LR Cox, L Eggeling, S Cardell, J Rossjohn, DI Godfrey, SM Behar, GS Besra, MB Brenner, M Brigl

2013-01-29

CD1d-restricted natural killer T (NKT) cells include two major subgroups. The most widely studied are Vα14Jα18+ invariant NKT (iNK..

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Recognition of CD1d-restricted antigens by natural killer T cells

J Rossjohn, DG Pellicci, O Patel, L Gapin, DI Godfrey

2012-12-01

Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines following T cell receptor (TCR) a..

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Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

O Patel, DG Pellicci, S Gras, ML Sandoval-Romero, AP Uldrich, T Mallevaey, AJ Clarke, J Le Nours, A Theodossis, SL Cardell, L Gapin, DI Godfrey, J Rossjohn

2012-09-01

Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen..

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