First-Line Management of Youth Depression

Functional connectivity signatures of major depressive disorder: machine learning analysis of two multicenter neuroimaging studies

Selene Gallo, Ahmed El-Gazzar, Paul Zhutovsky, Rajat M Thomas, Nooshin Javaheripour, Meng Li, Lucie Bartova, Deepti Bathula, Udo Dannlowski, Christopher Davey, Thomas Frodl, Ian Gotlib, Simone Grimm, Dominik Grotegerd, Tim Hahn, Paul J Hamilton, Ben J Harrison, Andreas Jansen, Tilo Kircher, Bernhard Meyer

2023-02-15

The promise of machine learning has fueled the hope for developing diagnostic tools for psychiatry. Initial studies showed high ac..

A distinct intra-individual suppression subnetwork in the brain's default mode network across cognitive tasks

Christine A Leonards, Ben J Harrison, Alec J Jamieson, Trevor Steward, Silke Lux, Alexandra Philipsen, Christopher G Davey

2022-09-20

Suppression of the brain's default mode network (DMN) during external goal-directed cognitive tasks has been consistently observed..

Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Laura S van Velzen, Maria R Dauvermann, Lejla Colic, Luca M Villa, Hannah S Savage, Yara J Toenders, Alyssa H Zhu, Joanna K Bright, Adrian Campos, Lauren E Salminen, Sonia Ambrogi, Rosa Ayesa-Arriola, Nerisa Banaj, Zeynep Basgoze, Jochen Bauer, Karina Blair, Robert James Blair, Katharina Brosch, Yuqi Cheng, Romain Colle

2022-09-07

Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding ..

Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Yash Patel, Jean Shin, Christoph Abe, Ingrid Agartz, Clara Alloza, Dag Alnaes, Sonia Ambrogi, Linda A Antonucci, Celso Arango, Volker Arolt, Guillaume Auzias, Rosa Ayesa-Arriola, Nerisa Banaj, Tobias Banaschewski, Cibele Bandeira, Zeynep Basgoze, Renata Basso Cupertino, Claiton HD Bau, Jochen Bauer, Sarah Baumeister

2022-07-25

BACKGROUND: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental orig..

The experience of young people receiving cognitive behavioural therapy for major depression: A qualitative study

Natalie Ferguson, Simon Rice, John Gleeson, Christopher G Davey, Sarah E Hetrick

2022-03-28

AIM: Major depressive disorder (MDD) has far reaching impacts for young people, their families and society. Cognitive behavioural ..

Suppressed activity of the rostral anterior cingulate cortex as a biomarker for depression remission

Christopher G Davey, Micah Cearns, Alec Jamieson, Ben J Harrison

2021-12-09

BACKGROUND: Suppression of the rostral anterior cingulate cortex (rACC) has shown promise as a prognostic biomarker for depression..

Altered effective connectivity of the extended face processing system in depression and its association with treatment response: findings from the YoDA-C randomized controlled trial

Alec J Jamieson, Ben J Harrison, Christopher G Davey

2021-12-01

Background Depression is commonly associated with fronto-amygdala dysfunction during the processing of emotional face expressions...

Rostral anterior cingulate network effective connectivity in depressed adolescents and associations with treatment response in a randomized controlled trial

Alec J Jamieson, Ben J Harrison, Adeel Razi, Christopher G Davey

2021-11-15

The rostral anterior cingulate cortex (rACC) is consistently implicated in the neurobiology of depression. While the functional co..

Altered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium

Nooshin Javaheripour, Meng Li, Tara Chand, Axel Krug, Tilo Kircher, Udo Dannlowski, Igor Nenadic, J Paul Hamilton, Matthew D Sacchet, Ian H Gotlib, Henrik Walter, Thomas Frodl, Simone Grimm, Ben J Harrison, Christian Robert Wolf, Sebastian Olbrich, Guido van Wingen, Lukas Pezawas, Gordon Parker, Matthew P Hyett

2021-10-07

Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be measured by assessing functional connectiv..

Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group.

Laura KM Han, Richard Dinga, Tim Hahn, Christopher RK Ching, Lisa T Eyler, Lyubomir Aftanas, Moji Aghajani, André Aleman, Bernhard T Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G Connolly, Baptiste Couvy-Duchesne, Kathryn R Cullen, Udo Dannlowski, Christopher G Davey, Danai Dima, Fabio LS Duran

2021-09-01

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We e..

Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts

Adrian Campos, Paul M Thompson, Dick J Veltman, Elena Pozzi, Laura S van Veltzen, Neda Jahanshad, Mark J Adams, Bernhard T Baune, Klaus Berger, Katharina Brosch, Robin Bulow, Colm G Connolly, Udo Dannlowski, Christopher G Davey, Greig de Zubicaray, Danai Dima, Tracy Erwin-Grabner, Jennifer W Evans, Cynthia HY Fu, Ian H Gotlib

2021-07-26

BACKGROUND: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-posit..

Relationships Between Different Dimensions of Social Support and Suicidal Ideation in Young People with Major Depressive Disorder

Carl Moller, Sue M Cotton, Paul B Badcock, Sarah E Hetrick, Michael Berk, Olivia M Dean, Andrew M Chanen, Christopher G Davey

2021-01-20

BACKGROUND: Suicidal ideation (SI) is a common feature of depression and is closely associated with suicidal behaviour. Social sup..

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Lianne Schmaal, Elena Pozzi, Tiffany C Ho, Laura S van Velzen, Ilya M Veer, Nils Opel, Eus JW Van Someren, Laura KM Han, Lybomir Aftanas, Andre Aleman, Bernhard T Baune, Klaus Berger, Tessa F Blanken, Liliana Capitao, Baptiste Couvy-Duchesne, Kathryn R Cullen, Udo Dannlowski, Christopher Davey, Tracy Erwin-Grabner, Jennifer Evans

2020-05-29

A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of ma..

Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group

Nils Opel, Anbupalam Thalamuthu, Yuri Milaneschi, Dominik Grotegerd, Claas Flint, Ramona Leenings, Janik Goltermann, Maike Richter, Tim Hahn, Georg Woditsch, Klaus Berger, Marco Hermesdorf, Andrew McIntosh, Heather C Whalley, Mathew A Harris, Frank P MacMaster, Henrik Walter, Ilya M Veer, Thomas Frodl, Angela Carballedo

2020-05-28

Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship bet..

Neurovegetative symptom subtypes in young people with major depressive disorder and their structural brain correlates

Yara J Toenders, Lianne Schmaal, Ben J Harrison, Richard Dinga, Michael Berk, Christopher G Davey

2020-04-20

Depression is a leading cause of burden of disease among young people. Current treatments are not uniformly effective, in part due..

The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial

Christopher G Davey, Andrew M Chanen, Sarah E Hetrick, Sue M Cotton, Aswin Ratheesh, Guenter P Amminger, John Koutsogiannis, Mark Phelan, Edward Mullen, Ben J Harrison, Simon Rice, Alexendra G Parker, Olivia M Dean, Amber Weller, Melissa Kerr, Amelia L Quinn, Lisa Catania, Nikolaos Kazantzis, Patrick D McGarry, Michael Berk

2019-09-01

BACKGROUND: Medication is commonly used to treat youth depression, but whether medication should be added to cognitive behavioural..

Neurodevelopmental correlates of the emerging adult self

Christopher G Davey, Alex D Fornito, Jesus Pujol, Michael Breakspear, Lianne Schmaal, Ben J Harrison

2019-04-01

The self-concept - the set of beliefs that a person has about themselves - shows significant development from adolescence to early..

Youth Depression Alleviation-Augmentation with an anti-inflammatory agent (YoDA-A): protocol and rationale for a placebo-controlled randomized trial of rosuvastatin and aspirin

Amelia L Quinn, Olivia M Dean, Christopher G Davey, Melissa Kerr, Susy M Harrigan, Sue M Cotton, Andrew M Chanen, Seetal Dodd, Aswin Ratheesh, G Paul Amminger, Mark Phelan, Amber Williams, Andrew Mackinnon, Francesco Giorlando, Shelley Baird, Simon Rice, Melissa O'Shea, Miriam R Schaefer, Edward Mullen, Sarah Hetrick

2018-02-01

AIM: There is growing support for the role of inflammation and oxidative stress in the pathophysiology of major depressive disorde..

A Brain Model of Disturbed Self-Appraisal in Depression

Christopher G Davey, Michael Breakspear, Jesus Pujol, Ben J Harrison

2017-09-01

OBJECTIVE: A disturbed sense of self is a core feature of depression. The medial prefrontal cortex, which has a central role in se..

Hard to look on the bright side: neural correlates of impaired emotion regulation in depressed youth

Katerina Stephanou, Christopher G Davey, Rebecca Kerestes, Sarah Whittle, Ben J Harrison

2017-07-01

The cognitive regulation of emotion is impaired in major depressive disorder and has been linked to an imbalance of pre-frontal-su..

Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

L Schmaal, DP Hibar, PG Saemann, GB Hall, BT Baune, N Jahanshad, JW Cheung, TGM van Erp, D Bos, MA Ikram, MW Vernooij, WJ Niessen, H Tiemeier, A Hofman, K Wittfeld, HJ Grabe, D Janowitz, R Buelow, M Selonke, H Voelzke

2017-06-01

The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studie..

The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): study protocol for a randomised control trial

Christopher G Davey, Andrew M Chanen, Sue M Cotton, Sarah E Hetrick, Melissa J Kerr, Michael Berk, Olivia M Dean, Kally Yuen, Mark Phelan, Aswin Ratheesh, Miriam R Schaefer, G Paul Amminger, Alexandra G Parker, Danijela Piskulic, Susy Harrigan, Andrew J Mackinnon, Ben J Harrison, Patrick D McGorry

2014-11-04

BACKGROUND: The aim of the Youth Depression Alleviation-Combined Treatment (YoDA-C) study is to determine whether antidepressant m..