Host responses to limit rotavirus infection and their evasion by rotavirus
Grant number: 1023786 | Funding period: 2012 - 2014
Rotavirus is the main cause of severe diarrhoea in children worldwide. In this project, we aim to understand the nature of the first-line immune response to rotavirus in the gut, and elucidate how RV counteracts this response to promote infection. These studies will increase our understanding of how rotavirus causes disease, and facilitate the choice of rotavirus targets for drug development and improved vaccines.
Related publications (5)
MHC class I expression in intestinal cells is reduced by rotavirus infection and increased in bystander cells lacking rotavirus antigen
Gavan Holloway, Fiona E Fleming, Barbara S Coulson
Detection of viral infection by host cells leads to secretion of type I interferon, which induces antiviral gene expression. The c..
Innate immune responses to rotavirus infection in macrophages depend on MAVS but involve neither the NLRP3 inflammasome nor JNK and p38 signaling pathways
Izabel JM Di Fiore, Gavan Holloway, Barbara S Coulson
Rotavirus infection is a major cause of life-threatening infantile gastroenteritis. The innate immune system provides an immediate..
NSP1 of human rotaviruses commonly inhibits NF-kappa B signalling by inducing beta-TrCP degradation
Izabel JM Di Fiore, Jessica A Pane, Gavan Holloway, Barbara S Coulson
Rotavirus is a leading cause of severe gastroenteritis in infants worldwide. Rotavirus nonstructural protein 1 (NSP1) is a virulen..
Rotavirus inhibits IFN-induced STAT nuclear translocation by a mechanism that acts after STAT binding to importin-alpha
Gavan Holloway, Vi T Dang, David A Jans, Barbara S Coulson
The importance of innate immunity to rotaviruses is exemplified by the range of strategies evolved by rotaviruses to interfere wit..