Understanding Tumour Formation Driven by the Signalling Protein Ras

Grant number: 1020525 | Funding period: 2012 - 2014

Completed

Abstract

Cancer is a cooperative process, involving mutations in several genes. Activation of the signaling protein, Ras, contributes to ~30% of human cancers, but alone is not sufficient for tumour formation. The identification of cooperating Tumour Suppressors (TSs), and their analysis in the vinegar fly, Drosophila, mammalian cells and mouse models is key to understanding cancer progression and for the development of therapeutic regimes

Related publications (2)

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

T Zoranovic, J Manent, L Willoughby, R Matos de Simoes, JE La Marca, S Golenkina, X Cuiping, S Gruber, B Angjeli, EE Kanitz, SJF Cronin, GG Neely, A Wernitznig, PO Humbert, KJ Simpson, CS Mitsiades, HE Richardson, JM Penninger

2018-10-01

Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for..

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species

J Manent, S Banerjee, R De Matos Simoes, T Zoranovic, C Mitsiades, JM Penninger, KJ Simpson, PO Humbert, HE Richardson

2017-10-05

Activation of Ras signalling occurs in ∼30% of human cancers; however, activated Ras alone is not sufficient for tumourigenesis. I..

University of Melbourne Researchers

Kaylene Simpson