Glia in remodelling the inner retina
Grant number: 1021042 | Funding period: 2012 - 2015
The development of treatments that restore vision assumes that the output neurons of the retina remain intact. Yet, there is now considerable evidence that the neurons that signal from the retina to the brain are altered in those that have degenerative diseases of the retina. Here, we will examine the cause of these cellular changes in an animal model and seek to prevent the loss of output neurons. This information is crucial for the development of treatments that seeks to restore vision.
Related publications (11)
Stimulation of a Suprachoroidal Retinal Prosthesis Drives Cortical Responses in a Feline Model of Retinal Degeneration
Felix P Aplin, Erica L Fletcher, Chi D Luu, Kirstan A Vessey, Penelope J Allen, Robyn H Guymer, Robert K Shepherd, Mohit N Shivdasani
Purpose: Retinal prostheses have emerged as a promising technology to restore vision in patients with severe photoreceptor degener..
Using the rd1 mouse to understand functional and anatomical retinal remodelling and treatment implications in retinitis pigmentosa: A review
M Kalloniatis, L Nivison-Smith, J Chua, ML Acosta, EL Fletcher
Retinitis Pigmentosa (RP) reflects a range of inherited retinal disorders which involve photoreceptor degeneration and retinal pig..
CHANGES IN GANGLION CELLS DURING RETINAL DEGENERATION
Susmita Saha, Ursula Greferath, Kirstan A Vessey, David B Grayden, Anthony N Burkitt, Erica L Fletcher
Inherited retinal degeneration such as retinitis pigmentosa (RP) is associated with photoreceptor loss and concomitant morphologic..
Retinal Changes in an ATP-Induced Model of Retinal Degeneration
Felix P Aplin, Kirstan A Vessey, Chi D Luu, Robyn H Guymer, Robert K Shepherd, Erica L Fletcher
In rodents and felines, intravitreal administration of adenosine triphosphate (ATP) has been shown to induce photoreceptor death p..
Inner retinal change in a novel rd1-FTL mouse model of retinal degeneration
Ursula Greferath, Emily E Anderson, Andrew I Jobling, Kirstan A Vessey, Gemma Martinez, Robb U de Iongh, Michael Kalloniatis, Erica L Fletcher
While photoreceptor loss is the most devastating result of inherited retinal degenerations such as retinitis pigmentosa, inner ret..
Adenosine Triphosphate-Induced Photoreceptor Death and Retinal Remodeling In Rats
Kirstan A Vessey, Ursula Greferath, Felix P Aplin, Andrew I Jobling, Joanna A Phipps, Tracy Ho, Robbert U De Iongh, Erica L Fletcher
Many common causes of blindness involve the death of retinal photoreceptors, followed by progressive inner retinal cell remodeling..
Mapping cation entry in photoreceptors and inner retinal neurons during early degeneration in the P23H-3 rat retina
Yuan Zhu, Stuti Mistra, Lisa Nivison-Smith, Monica L Acosta, Erica L Fletcher, Michael Kalloniatis
The proline-23-histidine line 3 (P23H-3) transgenic rat carries a human opsin gene mutation leading to progressive photoreceptor l..
Retinal amino acid neurochemistry in health and disease
Michael Kalloniatis, Chee Seang Loh, Monica L Acosta, Guido Tomisich, Yuan Zhu, Lisa Nivison-Smith, Erica L Fletcher, Jacqueline Chua, Daniel Sun, Niru Arunthavasothy
Advances in basic retinal anatomy, genetics, biochemical pathways and neurochemistry have not only provided a better understanding..