Control of gene expression during colorectal cancer progression
Grant number: 1026228 | Funding period: 2012 - 2014
Colorectal cancer (CRC) is the third most common cancer worldwide. About half of all patients diagnosed with the disease die as a result of its spread in the body. This project will investigate the role that a specific DNA-binding protein plays in orchestrating gene expression programs required for CRCs to spread. The research will provide new insights into underlying mechanisms of CRC progression as well as identify new therapeutic targets for aggressive forms of the disease.
Related publications (1)
Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells
Jeannine Diesch, Elaine Sanij, Omer Gilan, Christopher Love, Hoanh Tran, Nicholas I Fleming, Jason Ellul, Marcia Amalia, Izhak Haviv, Richard B Pearson, Eugene Tulchinsky, John M Mariadason, Oliver M Sieber, Ross D Hannan, Amardeep S Dhillon
Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational..