Control of the spread of breast cancer by small RNA molecules
Grant number: 1020280 | Funding period: 2012 - 2014
When breast cancer spreads to other organs, it results in high morbidity and mortality. MicroRNAs are a class of genes that control the expression of other genes, some of which are involved in the spread of cancer. In this project we will examine the function of two microRNA species that we have found to be associated with breast cancer spread. The anticipated outcome is a better knowledge of the genes that control cancer spread and the identification of new molecular targets for therapy.
Related publications (4)
Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer
Cameron N Johnstone, Yan Tu, Shenna Langenbach, David Baloyan, Andrew D Pattison, Peter Lock, Kara L Britt, Brian D Lehmann, Traude H Beilharz, Matthias Ernst, Robin L Anderson, Alastair G Stewart
Triple-negative breast cancer (TNBC) has a poor outcome compared to other breast cancer subtypes, and new therapies that target th..
FGF13 promotes metastasis of triple-negative breast cancer
Cameron N Johnstone, Andrew D Pattison, Paul F Harrison, David R Powell, Peter Lock, Matthias Ernst, Robin L Anderson, Traude H Beilharz
Triple-negative breast cancer (TNBC) represents 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to ot..
Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer
Cameron N Johnstone, Yvonne E Smith, Yuan Cao, Allan D Burrows, Ryan SN Cross, Xiawei Ling, Richard P Redvers, Judy P Doherty, Bedrich L Eckhardt, Anthony L Natoli, Christina M Restall, Erin Lucas, Helen B Pearson, Siddhartha Deb, Kara L Britt, Alexandra Rizzitelli, Jason Li, Judith H Harmey, Normand Pouliot, Robin L Anderson
The translation of basic research into improved therapies for breast cancer patients requires relevant preclinical models that inc..
MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways
X Li, S Roslan, CN Johnstone, JA Wright, CP Bracken, M Anderson, AG Bert, LA Selth, RL Anderson, GJ Goodall, PA Gregory, Y Khew-Goodall
The microRNA-200 (miR-200) family has a critical role in regulating epithelial-mesenchymal transition and cancer cell invasion thr..