Control of the spread of breast cancer by small RNA molecules

Grant number: 1020280 | Funding period: 2012 - 2014

Completed

Abstract

When breast cancer spreads to other organs, it results in high morbidity and mortality. MicroRNAs are a class of genes that control the expression of other genes, some of which are involved in the spread of cancer. In this project we will examine the function of two microRNA species that we have found to be associated with breast cancer spread. The anticipated outcome is a better knowledge of the genes that control cancer spread and the identification of new molecular targets for therapy.

Related publications (4)

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Cameron N Johnstone, Yvonne E Smith, Yuan Cao, Allan D Burrows, Ryan SN Cross, Xiawei Ling, Richard P Redvers, Judy P Doherty, Bedrich L Eckhardt, Anthony L Natoli, Christina M Restall, Erin Lucas, Helen B Pearson, Siddhartha Deb, Kara L Britt, Alexandra Rizzitelli, Jason Li, Judith H Harmey, Normand Pouliot, Robin L Anderson

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MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways

X Li, S Roslan, CN Johnstone, JA Wright, CP Bracken, M Anderson, AG Bert, LA Selth, RL Anderson, GJ Goodall, PA Gregory, Y Khew-Goodall

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The microRNA-200 (miR-200) family has a critical role in regulating epithelial-mesenchymal transition and cancer cell invasion thr..