Stem cell therapy to treat gut motility disorders
Grant number: 1019931 | Funding period: 2012 - 2014
Neurons within the wall of the bowel play an essential role in gut motility. A number of motility disorders are caused by diseased enteric neurons, but there are currently no effective treatments for these diseases. We will use animal models of a pediatric motility disorder to examine whether stem cells implanted into the colon can generate neurons and restore normal motility.
Related publications (4)
Surgical Intervention to Rescue Hirschsprung Disease in a Rat Model
Lincon A Stamp, Florian Obermayr, Louise Pontell, Heather M Young, Dan Xie, David H Croaker, Zan-Min Song, John B Furness
BACKGROUND/AIMS: Rats with a spontaneous null mutation in endothelin receptor type B or Ednrb (sl/sl; spotting lethal) lack enteri..
Enteric neural progenitors are more efficient than brain-derived progenitors at generating neurons in the colon
Quan Findlay, Kiryu K Yap, Annette J Bergner, Heather M Young, Lincon A Stamp
Gut motility disorders can result from an absent, damaged, or dysfunctional enteric nervous system (ENS). Cell therapy is an excit..
Transplanted progenitors generate functional enteric neurons in the postnatal colon
Ryo Hotta, Lincon A Stamp, Jaime PP Foong, Sophie N McConnell, Annette J Bergner, Richard B Anderson, Hideki Enomoto, Donald F Newgreen, Florian Obermayr, John B Furness, Heather M Young
Cell therapy has the potential to treat gastrointestinal motility disorders caused by diseases of the enteric nervous system. Many..