How do Multiple Sclerosis Risk genes work?
Grant number: 1032486 | Funding period: 2012 - 2015
In Multiple Sclerosis (MS), the immune system repeatedly attacks the brain and spinal cord. In the last three years, rapid progress has been made in understanding genetic risk factors for MS, and more than 20 are known, but their function is not understood. The proposed study will recruit patients with MS and healthy controls to isolate five major immune cell types, and will assess how risk genes influence these cells. We hope to obtain a much better picture of how genetic risk factors for MS actually work.
Related publications (3)
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells
Melissa M Gresle, Margaret A Jordan, Jim Stankovich, Tim Spelman, Laura J Johnson, Louise Laverick, Alison Hamlett, Letitia D Smith, Vilija G Jokubaitis, Josephine Baker, Jodi Haartsen, Bruce Taylor, Jac Charlesworth, Melanie Bahlo, Terence P Speed, Matthew A Brown, Judith Field, Alan G Baxter, Helmut Butzkueven
At least 200 single-nucleotide polymorphisms (SNPs) are associated with multiple sclerosis (MS) risk. A key function that could me..
Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis
Robert Hoepner, Maud Bagnoud, Maximilian Pistor, Anke Salmen, Myriam Briner, Helen Synn, Lisa Schrewe, Kirsten Guse, Farhad Ahmadi, Seray Demir, Louis Laverick, Melissa Gresle, Paul Worley, Holger Michael Reichardt, Helmut Butzkueven, Ralf Gold, Imke Metz, Fred Luehder, Andrew Chan
The limited efficacy of glucocorticoids (GCs) during therapy of acute relapses in multiple sclerosis (MS) leads to long-term disab..
Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status
Michele D Binder, Andrew D Fox, Daniel Merlo, Laura J Johnson, Lauren Giuffrida, Sarah E Calvert, Rainer Akkermann, Gerry ZM Ma, Ashwyn A Perera, Melissa M Gresle, Louise Laverick, Grace Foo, Marzena J Fabis-Pedrini, Timothy Spelman, Margaret A Jordan, Alan G Baxter, Simon Foote, Helmut Butzkueven, Trevor J Kilpatrick, Judith Field