Tissue engineering functional liver tissue
Grant number: 1023187 | Funding period: 2012 - 2015
Many patients suffering from severe liver disease require a liver transplant, but due to a shortage of liver donors, many die prior to liver transplantation. This study investigates novel methods of growing liver tissue from mature liver cells called hepatocytes, or, liver stem cells implanted in a plastic chamber in mice with acute and chronic liver disease. It is anticipated that new liver tissue will grow in the chamber, the mice will be cured, and that this technique can be translated to humans with liver disease.
Related publications (2)
Characterization of isolated liver sinusoidal endothelial cells for liver bioengineering
AM Dingle, KK Yap, Y-W Gerrand, CJ Taylor, E Keramidaris, Z Lokmic, AM Kong, HL Peters, WA Morrison, GM Mitchell
BACKGROUND: The liver sinusoidal capillaries play a pivotal role in liver regeneration, suggesting they may be beneficial in liver..
Enhanced liver progenitor cell survival and differentiation in vivo by spheroid implantation in a vascularized tissue engineering chamber
Kiryu K Yap, Aaron M Dingle, Jason A Palmer, Raminder S Dhillon, Zerina Lokmic, Anthony J Penington, George C Yeoh, Wayne A Morrison, Geraldine M Mitchell
Liver tissue engineering is hampered by poor implanted cell survival due to inadequate vascularization and cell-cell/cell-matrix i..