Tissue Engineering Functional Liver Tissue
Grant number: 1023187 | Funding period: 2012 - 2015
Many patients suffering from severe liver disease require a liver transplant, but due to a shortage of liver donors, many die prior to liver transplantation. This study investigates novel methods of growing liver tissue from mature liver cells called hepatocytes, or, liver stem cells implanted in a plastic chamber in mice with acute and chronic liver disease. It is anticipated that new liver tissue will grow in the chamber, the mice will be cured, and that this technique can be translated to humans with liver disease.
Related publications (1)
Enhanced liver progenitor cell survival and differentiation in vivo by spheroid implantation in a vascularized tissue engineering chamber
Kiryu K Yap, Aaron M Dingle, Jason A Palmer, Raminder S Dhillon, Zerina Lokmic, Anthony J Penington, George C Yeoh, Wayne A Morrison, Geraldine M Mitchell