Modulatory control of arousal and affect in health and disease
Grant number: 1024885 | Funding period: 2012 - 2014
Mental illness is a significant social and economic burden worldwide and knowledge of the underlying causes and more effective therapies are required. Our research aims to use pre-clinical animal models to characterize a little studied brain neuronal network implicated in control of arousal and stress, which could lead to improved treatment of psychiatric disorders such as depression.
Related publications (10)
Relaxin-3 Inputs Target Hippocampal Interneurons and Deletion of Hilar Relaxin-3 Receptors in "Floxed-RXFP3" Mice Impairs Spatial Memory
M Haidar, G Guevremont, C Zhang, RAD Bathgate, E Timofeeva, CM Smith, AL Gundlach
Hippocampus is innervated by γ-aminobutyric acid (GABA) "projection" neurons of the nucleus incertus (NI), including a population ..
Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3/RXFP3 Deficiency
Mouna Haidar, Monica Lam, Berenice E Chua, Craig M Smith, Andrew L Gundlach
Methamphetamine (METH) is a highly addictive psychostimulant, and cessation of use is associated with reduced monoamine signalling..
Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice
Cary Zhang, Berenice E Chua, Annie Yang, Faze Shabanpoor, Mohammad Akhter Hossain, John D Wade, K Johan Rosengren, Craig M Smith, Andrew L Gundlach
Anxiety disorders are among the most prevalent neuropsychiatric conditions, but their precise aetiology and underlying pathophysio..
Involvement of central relaxin-3 signalling in sodium (salt) appetite
Craig M Smith, Lesley L Walker, Berenice E Chua, Michael J McKinley, Andrew L Gundlach, Derek A Denton, Andrew J Lawrence
NEW FINDINGS: What is the central question of this study? Sodium appetite is controlled by conserved neuronal transmitter-receptor..
Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: Implications for role of relaxin-3/RXFP3 signalling in sustained arousal
Ihaia T Hosken, Steven W Sutton, Craig M Smith, Andrew L Gundlach
Anatomical and pharmacological evidence suggests the neuropeptide, relaxin-3, is the preferred endogenous ligand for the relaxin f..
Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice
Craig M Smith, Berenice E Chua, Cary Zhang, Andrew W Walker, Mouna Haidar, David Hawkes, Fazel Shabanpoor, Mohammad Akhter Hossain, John D Wade, K Johan Rosengren, Andrew L Gundlach
Behavioural arousal in mammals is regulated by various interacting central monoamine- and peptide-neurotransmitter/receptor system..
Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuro psychiatric diseases?
Craig M Smith, Andrew W Walker, Ihaia T Hosken, Berenice E Chua, Cary Zhang, Mouna Haidar, Andrew L Gundlach
Animal and clinical studies of gene-environment interactions have helped elucidate the mechanisms involved in the pathophysiology ..
Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat
Philip J Ryan, Elena Buechler, Fazel Shabanpoor, Mohammed Akhter Hossain, John D Wade, Andrew J Lawrence, Andrew L Gundlach
Relaxin-3 is a recently discovered neuropeptide and the results of earlier anatomical and pharmacological studies suggest it plays..
Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization
Linda J Chan, Craig M Smith, Berenice E Chua, Feng Lin, Ross AD Bathgate, Frances Separovic, Andrew L Gundlach, Mohammed Akhter Hossain, John D Wade
Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in ..