Enhancing the clinical potential of relaxin
Grant number: 1023078 | Funding period: 2012 - 2014
The hormone relaxin mediates cardiovascular and kidney changes during pregnancy. These important functions have led to its current use in clinical trials for the treatment of acute heart failure, a condition affecting millions of patients worldwide. However, there is an urgent need for a longer lasting form of relaxin for prolonged treatment of patients. Our studies will focus on understanding the blood breakdown of the peptide to lead to the design of longer lasting relaxin analogues.
Related publications (24)
Total Chemical Synthesis of a Nonfibrillating Human Glycoinsulin
Mohammed Akhter Hossain, Rio Okamoto, John A Karas, Praveen Praveen, Mengjie Liu, Briony E Forbes, John D Wade, Yasuhiro Kajihara
Glycosylation is an accepted strategy to improve the therapeutic value of peptide and protein drugs. Insulin and its analogues are..
Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat
Werner I Furuya, Rishi R Dhingra, Andrew L Gundlach, Mohammad Akhter Hossain, Mathias Dutschmann
The neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal..
The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity
Nitin A Patil, Ross AD Bathgate, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger Summers, Johannes Grosse, Richard A Hughes, John D Wade, Mohammed Akhter Hossain
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
Mohammed Akhter Hossain, Martina Kocan, Song T Yao, Simon G Royce, Vinojini B Nair, Christopher Siwek, Nitin A Patil, Ian P Harrison, K Johan Rosengren, Stavros Selemidis, Roger J Summers, John D Wade, Ross AD Bathgate, Chrishan S Samuel
Total chemical synthesis of a heterodimeric interchain bis-lactam-linked Peptide: application to an analogue of human insulin-like Peptide 3.
John Karas, Fazel Shabanpoor, Mohammed Akhter Hossain, James Gardiner, Frances Separovic, John D Wade, Denis B Scanlon
Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary confor..