Enhancing The Clinical Potential Of Relaxin

Grant number: 1023078 | Funding period: 2012 - 2014

Completed

Abstract

The hormone relaxin mediates cardiovascular and kidney changes during pregnancy. These important functions have led to its current use in clinical trials for the treatment of acute heart failure, a condition affecting millions of patients worldwide. However, there is an urgent need for a longer lasting form of relaxin for prolonged treatment of patients. Our studies will focus on understanding the blood breakdown of the peptide to lead to the design of longer lasting relaxin analogues.

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The Importance of Tryptophan B28 in H2 Relaxin for RXFP2 Binding and Activation

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