Understanding influenza virus factors that cause illness in humans
Grant number: 1026619 | Funding period: 2012 - 2015
Influenza virus produces a protein of undefined function called PB1-F2. Infection of mice with virus expressing PB1-F2 from virulent strains causes severe lung inflammation, while PB1-F2 from milder seasonal viruses does not. We will examine how PB1-F2 influences virulence of human influenza in the ferret, which exhibits the same illness as humans. This work will help understand the disease severity of newly evolved influenza viruses of humans and the role of PB1-F2 in mediating this.
Related publications (2)
Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection
Julie McAuley, Yi-Mo Deng, Brad Gilbertson, Charley Mackenzie-Kludas, Ian Barr, Lorena Brown
Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-l..
Induction of memory cytotoxic T cells to influenza A virus and subsequent viral clearance is not modulated by PB1-F2-dependent inflammasome activation
Patricia Hoi Yee Lee, Nicola Bird, Charley MacKenzie-Kludas, Ashley Mansell, Katherine Kedzierska, Lorena Brown, Julie McAuley
Expression of the viral virulence protein PB1-F2 during infection has been linked to NLRP3 inflammasome complex activation in macr..