Role of T cell in Chronic Periodontitis
Grant number: 1029878 | Funding period: 2012 - 2014
Particular immune cell populations (innate T cells), have a critical role in immunity. These cells are stimulated by bacterial cell wall components and are one of the first cells to appear after infection. We have shown that these innate T cells are stimulated by oral bacteria that cause the disease chronic periodontitis. This project will investigate how these innate T cells affect bacterial induced periodontitis and what role they play in disease outcomes.
Related publications (17)
Peripheral memory T-cell profile is modified in patients undergoing periodontal management
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson
AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..
T helper 17 cell-related cytokines in serum and saliva during management of periodontitis
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Ivan B Darby, Neil M O'Brien-Simpson, Eric C Reynolds
AIM: T helper (Th)17 cells are implicated in the pathogenesis of periodontitis. This study investigated the effect of periodontal ..
Peripheral neutrophil phenotypes during management of periodontitis
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Eric C Reynolds, Neil M O'Brien-Simpson, Ivan B Darby
BACKGROUND AND OBJECTIVES: Neutrophils are emerging as a key player in periodontal pathogenesis. The surface expression of cellula..
Covalent conjugation of cationic antimicrobial peptides with a beta-lactam antibiotic core
Wenyi Li, Neil M O'Brien-Simpson, James A Holden, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade
To combat the serious issue of increasing global antibiotic resistance, new antimicrobial therapies are urgently required. As one ..
The Effect of Selective D- or N-alpha-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20
Wenyi Li, Zhe Sun, Neil M O'Brien-Simpson, Laszlo Otvos, Eric C Reynolds, Mohammed A Hossain, Frances Separovic, John D Walde
In vivo pharmacokinetics studies have shown that the proline-rich antimicrobial peptide, A3-APO, which is a discontinuous dimer of..
C-Terminal Modification and Multimerization Increase the Efficacy of a Proline-Rich Antimicrobial Peptide
Wenyi Li, Neil M O'Brien-Simpson, Shenggen Yao, Julien Tailhades, Eric C Reynolds, Raymond M Dawson, Laszlo Otvos, Mohammed Akhter Hossain, Frances Separovic, John D Wade
Two series of branched tetramers of the proline-rich antimicrobial peptide (PrAMP), Chex1-Arg20, were prepared to improve antibact..
Fluorescent Ion Efflux Screening Assay for Determining Membrane-Active Peptides
Neil M O'Brien-Simpson, Wenyi Li, Namfon Pantarat, Mohammed Akhter Hossain, Frances Separovic, John D Wade, Eric C Reynolds
A major global health threat is the emergence of antibiotic-resistant microbes. Coupled with a lack of development of modified ant..
Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses
Katelyn T Gause, Yan Yan, Neil M O'Brien-Simpson, Jiwei Cui, Jason C Lenzo, Eric C Reynolds, Frank Caruso
Vaccine adjuvants that can induce robust protective immunity are highly sought after for the development of safer and more effecti..
Determination of Active Phagocytosis of Unopsonized Porphyromonas gingivalis by Macrophages and Neutrophils Using the pH-Sensitive Fluorescent Dye pHrodo
Jason C Lenzo, Neil M O'Brien-Simpson, Jessica Cecil, James A Holden, Eric C Reynolds
Phagocytosis of pathogens is an important component of the innate immune system that is responsible for the removal and degradatio..
Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane
Wenyi Li, Neil M O'Brien-Simpson, Julien Tailhades, Namfon Pantarat, Raymond M Dawson, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade
A3-APO, a de novo designed branched dimeric proline-rich antimicrobial peptide (PrAMP), is highly effective against a variety of i..
Physicochemical and Immunological Assessment of Engineered Pure Protein Particles with Different Redox States
Katelyn T Gause, Yan Yan, Jiwei Cui, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Frank Caruso
The development of subunit antigen delivery formulations has become an important research endeavor, especially in cases where a wh..
C-Terminal Modifications Broaden Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20
Wenyi Li, Julien Tailhades, M Akhter Hossain, Neil M O'Brien-Simpson, Eric C Reynolds, Laszlo Otvos, Frances Separovic, John D Wade
A series of N- and C-terminal modifications of the monomeric proline-rich antimicrobial peptide, Chex1-Arg20, was obtained via dif..
Porphyromonas gingivalis Lipopolysaccharide Weakly Activates M1 and M2 Polarized Mouse Macrophages but Induces Inflammatory Cytokines
James A Holden, Troy J Attard, Katrina M Laughton, Ashley Mansell, Neil M O'Brien-Simpson, Eric C Reynolds
Porphyromonas gingivalis is associated with chronic periodontitis, an inflammatory disease of the tooth's supporting tissues. Macr..
Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria
Wenyi Li, Julien Tailhades, Neil M O'Brien-Simpson, Frances Separovic, Laszlo Otvos, M Akhter Hossain, John D Wade
The increasing resistance of pathogens to antibiotics causes a huge clinical burden that places great demands on academic research..
Acute phase protein and cytokine levels in serum and saliva: A comparison of detectable levels and correlations in a depressed and healthy adolescent sample
Michelle L Byrne, Neil M O'Brien-Simpson, Eric C Reynolds, Katrina A Walsh, Katrina Laughton, Joanna M Waloszek, Michael J Woods, John Trinder, Nicholas B Allen
Recent research has examined associations between inflammation and mental health, and has increasingly focused on utilising younge..
Clinical isolates and laboratory reference Candida species and strains have varying abilities to form biofilms
Ali D Alnuaimi, Neil M O'Brien-Simpson, Eric C Reynolds, Michael J McCullough
Candida biofilms are a major virulence trait for this yeast. In this study, the biofilm-forming ability of the major medically imp..
Polymerisation of a T Cell Epitope with an Immunostimulatory C3d Peptide Sequence Enhances Antigen Specific T Cell Responses
Neil M O'Brien-Simpson, Troy J Attard, Baihui Zheng, Katrina A Walsh, Eric C Reynolds
The complement protein C3d and C3d derived peptides that bind CD21 are known to enhance immunity to co-immunised antigens. In this..