Role of T cell in Chronic Periodontitis
Grant number: 1029878 | Funding period: 2012 - 2014
Particular immune cell populations (innate T cells), have a critical role in immunity. These cells are stimulated by bacterial cell wall components and are one of the first cells to appear after infection. We have shown that these innate T cells are stimulated by oral bacteria that cause the disease chronic periodontitis. This project will investigate how these innate T cells affect bacterial induced periodontitis and what role they play in disease outcomes.
Related publications (17)
Peripheral memory T-cell profile is modified in patients undergoing periodontal management
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson
AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..
T helper 17 cell-related cytokines in serum and saliva during management of periodontitis
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Ivan B Darby, Neil M O'Brien-Simpson, Eric C Reynolds
AIM: T helper (Th)17 cells are implicated in the pathogenesis of periodontitis. This study investigated the effect of periodontal ..
Peripheral neutrophil phenotypes during management of periodontitis
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Eric C Reynolds, Neil M O'Brien-Simpson, Ivan B Darby
BACKGROUND AND OBJECTIVES: Neutrophils are emerging as a key player in periodontal pathogenesis. The surface expression of cellula..
Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane
Wenyi Li, Neil M O'Brien-Simpson, Julien Tailhades, Namfon Pantarat, Raymond M Dawson, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade
Acute phase protein and cytokine levels in serum and saliva: A comparison of detectable levels and correlations in a depressed and healthy adolescent sample
Michelle L Byrne, Neil M O'Brien-Simpson, Eric C Reynolds, Katrina A Walsh, Katrina Laughton, Joanna M Waloszek, Michael J Woods, John Trinder, Nicholas B Allen