The Role Of The Disease-Related Proteins App And Tau In Iron Content Within The Brain

Grant number: 1025774 | Funding period: 2012 - 2014

Completed

Abstract

We have recently discovered a novel relationship between amyloid precursor protein (APP) and tau in regulating neuronal iron balance. This project will establish how tau aids APP transport to the cell surface where it assists cellular iron release. A commonality in some neurodegenerative diseases are disruptions in either proteinsÍ function and iron-related excitotoxicity. Understanding the iron role of APP and tau will lead to a therapeutic mechanism of action and better future drug design.