Brain Control of Blood Sugar
Grant number: 1025031 | Funding period: 2012 - 2014
Hypoglycaemia or low blood sugar is a major side-effect of the treatment of diabetes. Exposure to hypoglycaemia results in changes in the brain (neuroplasticity) that reduce the awareness of hypoglycaemia, often with serious consequences. Hypoglycaemia triggers the production of several hormones including adrenaline which restore normal blood glucose. This process is incompletely understood. This research project will identify key components of the neurocircuitry that controls blood sugar.
Related publications (6)
Perifornical hypothalamic pathway to the adrenal gland: Role for glutamatergic transmission in the glucose counter-regulatory response
A Sabetghadam, WS Korim, AJM Verberne
Adrenaline is an important counter-regulatory hormone that helps restore glucose homeostasis during hypoglycaemia. However, the ne..
Activation of medulla-projecting perifornical neurons modulates the adrenal sympathetic response to hypoglycemia: involvement of orexin type 2 (OX2-R) receptors.
WS Korim, I Llewellyn-Smith, AJ Verberne
Iatrogenic hypoglycemia in response to insulin treatment is commonly experienced by patients with type 1 diabetes and can be life ..
Catecholaminergic C3 Neurons Are Sympathoexcitatory and Involved in Glucose Homeostasis
Clement Menuet, Charles P Sevigny, Angela A Connelly, Jaspreet K Bassi, Nikola Jancovski, David A Williams, Colin R Anderson, Ida J Llewellyn-Smith, Angelina Y Fong, Andrew M Allen
Brainstem catecholaminergic neurons play key roles in the autonomic, neuroendocrine, and behavioral responses to glucoprivation, y..
Orexinergic Activation of Medullary Premotor Neurons Modulates the Adrenal Sympathoexcitation to Hypothalamic Glucoprivation
Willian S Korim, Lama Bou Farah, Simon McMullan, Anthony JM Verberne
Glucoprivation activates neurons in the perifornical hypothalamus (PeH) and in the rostral ventrolateral medulla (RVLM), which res..