Brain Control of Blood Sugar

Grant number: 1025031 | Funding period: 2012 - 2014

Completed

Abstract

Hypoglycaemia or low blood sugar is a major side-effect of the treatment of diabetes. Exposure to hypoglycaemia results in changes in the brain (neuroplasticity) that reduce the awareness of hypoglycaemia, often with serious consequences. Hypoglycaemia triggers the production of several hormones including adrenaline which restore normal blood glucose. This process is incompletely understood. This research project will identify key components of the neurocircuitry that controls blood sugar.

Related publications (8)

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RVLM C1 Neurons Innervate Sacral as well as Thoracolumbar Autonomic Preganglionic Neurons in the Rat

IJ Llewellyn-Smith, L Travis, AA Connelly, JK Bassi, C Menuet, AM Allen

2026-02-01

We examined the distribution of axons throughout the spinal cord of the rat that were either immunoreactive for the adrenaline-syn..

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Functional Topography in the Rat Rostral Ventrolateral Medulla (RVLM): Distribution of C1 Neurons that Respond to Cardiovascular versus Metabolic Stimuli

Ida J Llewellyn‐Smith, Manjula Senthilkumaran, Frank Spradley, Gisele M Etelvino, Larisa Bobrovskaya, Pascal Carrive, Patrick J Mueller, Anthony JM Verberne

2019-04-01

<jats:p>Neurons controlling cardiovascular responses and glucose counter regulation are co‐located within the RVLM, with activated..

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Insulin-responsive autonomic neurons in rat medulla oblongata

M Senthilkumaran, L Bobrovskaya, AJM Verberne, IJ Llewellyn-Smith

2018-11-01

Low blood glucose activates brainstem adrenergic and cholinergic neurons, driving adrenaline secretion from the adrenal medulla an..

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Perifornical hypothalamic pathway to the adrenal gland: Role for glutamatergic transmission in the glucose counter-regulatory response

A Sabetghadam, WS Korim, AJM Verberne

2017-03-01

Adrenaline is an important counter-regulatory hormone that helps restore glucose homeostasis during hypoglycaemia. However, the ne..

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Adrenaline: Insights into its metabolic roles in hypoglycaemia and diabetes

AJM Verberne, WS Korim, A Sabetghadam, IJ Llewellyn-Smith

2016-05-01

Adrenaline is a hormone that has profound actions on the cardiovascular system and is also a mediator of the fight-or-flight respo..

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Activation of medulla-projecting perifornical neurons modulates the adrenal sympathetic response to hypoglycemia: involvement of orexin type 2 (OX2-R) receptors.

WS Korim, I Llewellyn-Smith, AJ Verberne

2015-01-01

Iatrogenic hypoglycemia in response to insulin treatment is commonly experienced by patients with type 1 diabetes and can be life ..

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Catecholaminergic C3 neurons are sympathoexcitatory and involved in glucose homeostasis

C Menuet, CP Sevigny, AA Connelly, JK Bassi, N Jancovski, DA Williams, CR Anderson, IJ Llewellyn-Smith, AY Fong, AM Allen

2014-11-05

Brainstem catecholaminergic neurons play key roles in the autonomic, neuroendocrine, and behavioral responses to glucoprivation, y..

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Orexinergic activation of medullary premotor neurons modulates the adrenal sympathoexcitation to hypothalamic glucoprivation

WS Korim, LB Farah, S McMullan, AJM Verberne

2014-01-01

Glucoprivation activates neurons in the perifornical hypothalamus (PeH) and in the rostral ventrolateral medulla (RVLM), which res..

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