CONTROL OF MUSCULOSKELETAL FUNCTION AND INSULIN RESISTANCE BY ANDROGENS IN MALES
Grant number: 1024139 | Funding period: 2012 - 2015
Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases general well being and contributes to muscle weakness, bone fragility and weight gain. By using cutting edge imaging and molecular technologies, we will help to explain the underlying mechanisms of how AD leads to these negative effects. This should ultimately lead to reduction of adverse outcomes of AD, which include fractures and cardiovascular events.
Related publications (35)
Zoledronic acid does not affect insulin resistance in men receiving androgen deprivation therapy: a prespecified secondary analysis of a randomised controlled trial
Ada S Cheung, Rudolf Hoermann, Jasmine Zhu, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
BACKGROUND: Animal studies suggest that undercarboxylated osteocalcin may improve insulin sensitivity via its effect on testicular..
Biomechanical Leg Muscle Function During Stair Ambulation in Men Receiving Androgen Deprivation Therapy
Ada S Cheung, Hans A Gray, Anthony G Schache, Rudolf Hoermann, Jarrod Bicknell, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann
BACKGROUND: The role of testosterone in maintaining functional performance in older men remains uncertain. METHODS: We conducted a..
Differing Effects of Zoledronic Acid on Bone Microarchitecture and Bone Mineral Density in Men Receiving Androgen Deprivation Therapy: A Randomized Controlled Trial
Ada S Cheung, Rudolf Hoermann, Ali Ghasem-Zadeh, Alistair J Tinson, Vivian Ly, Stefan Milevski, Daryl Lim Joon, Jeffrey D Zajac, Ego Seeman, Mathis Grossmann
Androgen deprivation therapy (ADT) given to men with prostate cancer causes rapid and severe sex steroid deficiency, leading to in..
Testicular volume and clinical correlates of hypothalamic-pituitary-testicular function: A cross-sectional study in obese men
Mark Ng Tang Fui, Rudolf Hoermann, Gary Wittert, Mathis Grossmann
The aim of this study was to determine whether testicular volume is correlated with clinical and biochemical markers of hypothalam..
A body shape index (ABSI) reflects body composition changes in response to testosterone treatment in obese men
Rudolf Hoermann, Mark Ng Tang Fui, Jesse C Krakauer, Nir Y Krakauer, Mathis Grossmann
BACKGROUND: Interventions such as testosterone treatment may change body composition and metabolic outcomes without substantial ch..
Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy
Ada S Cheung, Christopher Cunningham, Dong-Kyoon Daniel Ko, Vivian Ly, Hans Gray, Rudolf Hoermann, Boyd JG Strauss, Ebrahim Bani Hassan, Gustavo Duque, Peter Ebeling, Marcus G Pandy, Jeffrey D Zajac, Mathis Grossmann
CONTEXT: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walk..
Persisting adverse body composition changes 2 years after cessation of androgen deprivation therapy for localised prostate cancer
Ada S Cheung, Alistair J Tinson, Stefan Milevski, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: Hypogonadism from androgen deprivation therapy (ADT) for prostate cancer causes adverse body composition changes associ..
Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer
Ada S Cheung, Casey de Rooy, Itamar Levinger, Kesha Rana, Michele V Clarke, Jackie M How, Andrew Garnham, Catriona McLean, Jeffrey D Zajac, Rachel A Davey, Mathis Grossmann
Androgen deprivation therapy (ADT) decreases muscle mass and function but no human studies have investigated the underlying geneti..
The effects of testosterone on body composition in obese men are not sustained after cessation of testosterone treatment
Mark Ng Tang Fui, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann
BACKGROUND: Testosterone treatment in obese dieting men augments the diet-associated loss of fat mass, but protects against loss o..
Hypothalamic-Pituitary-Thyroid Axis Set Point Alterations Are Associated With Body Composition in Androgen-Deprived Men
Rudolf Hoermann, Ada S Cheung, Michele Milne, Mathis Grossmann
OBJECTIVE: Androgen deprivation therapy (ADT) given to men with prostate cancer is associated with metabolically adverse changes i..
Quality of life decrements in men with prostate cancer undergoing androgen deprivation therapy
Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with decreased quality of life (QoL), controlled prospecti..
Symptomatic response to testosterone treatment in dieting obese men with low testosterone levels in a randomized, placebo-controlled clinical trial
M Ng Tang Fui, R Hoermann, La Prendergast, Jd Zajac, M Grossmann
BACKGROUND: Obese men commonly have reductions in circulating testosterone and report symptoms consistent with androgen deficiency..
Androgen deprivation causes selective deficits in the biomechanical leg muscle function of men during walking: a prospective case-control study
Ada S Cheung, Hans Gray, Anthony G Schache, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann
BACKGROUND: Although muscle mass declines with testosterone deficiency in men, previous studies of muscle function have not demons..
Testosterone therapy increases muscle mass in men with cirrhosis and low testosterone: A randomised controlled trial
Marie Sinclair, Mathis Grossmann, Rudolf Hoermann, Peter W Angus, Paul J Gow
BACKGROUND & AIMS: Low testosterone and sarcopenia are common in men with cirrhosis and both are associated with increased mortali..
Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial
Mark Ng Tang Fui, Luke A Prendergast, Philippe Dupuis, Manjri Raval, Boyd J Strauss, Jeffrey D Zajac, Mathis Grossmann
BACKGROUND: Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. ..
Relationships between insulin resistance and frailty with body composition and testosterone in men undergoing androgen deprivation therapy for prostate cancer
Ada S Cheung, Rudolf Hoermann, Philippe Dupuis, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with insulin resistance and frailty, controlled prospectiv..
Correlation of visceral adipose tissue measured by Lunar Prodigy dual X-ray absorptiometry with MRI and CT in older men
AS Cheung, C de Rooy, R Hoermann, EJ Gianatti, EJ Hamilton, G Roff, JD Zajac, M Grossmann
Quantification of abdominal visceral adipose tissue (VAT) is important to understand obesity-related comorbidities. We hypothesize..
Association of sex hormone-binding globulin and free testosterone with mortality in men with type 2 diabetes mellitus
Aye N Tint, Rudolf Hoermann, Henry Wong, Elif I Ekinci, Richard J MacIsaac, George Jerums, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: Low circulating testosterone levels have been associated with increased mortality in men. We hypothesized that the prog..
Effect of testosterone treatment on cardiac biomarkers in a randomized controlled trial of men with type 2 diabetes
Emily J Gianatti, Rudolf Hoermann, Que Lam, Philippe Dupuis, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: To assess the effect of testosterone treatment on cardiac biomarkers in men with type 2 diabetes (T2D). DESIGN: Randomi..
Effects of testosterone treatment on glucose metabolism and symptoms in men with type 2 diabetes and the metabolic syndrome: a systematic review and meta-analysis of randomized controlled clinical trials
Mathis Grossmann, Rudolf Hoermann, Gary Wittert, Bu B Yeap
CONTEXT: The effects of testosterone treatment on glucose metabolism and other outcomes in men with type 2 diabetes (T2D) and/or t..
Sex steroids levels in chronic kidney disease and kidney transplant recipients: associations with disease severity and prediction of mortality
Mathis Grossmann, Rudolf Hoermann, Mark Ng Tang Fui, Jeffrey D Zajac, Franscesco L Ierino, Matthew A Roberts
OBJECTIVE: Our objective was to characterize and evaluate prognostic implications of circulating sex steroids in patients at diffe..
Effect of Testosterone Treatment on Constitutional and Sexual Symptoms in Men With Type 2 Diabetes in a Randomized, Placebo-Controlled Clinical Trial
Emily J Gianatti, Philippe Dupuis, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: The objective of the study was to assess the effect of T treatment on constitutional and sexual symptoms in men with ty..
Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial
Emily J Gianatti, Philippe Dupuis, Rudolf Hoermann, Boyd J Strauss, John M Wentworth, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: To determine whether testosterone therapy improves glucose metabolism in men with type 2 diabetes (T2D) and lowered tes..
Obesity and age as dominant correlates of low testosterone in men irrespective of diabetes status
M Ng Tang Fui, R Hoermann, AS Cheung, EJ Gianatti, JD Zajac, M Grossmann
Although men with type 2 diabetes (T2D) frequently have lowered testosterone levels, it is not well established whether this is as..
Cardiovascular risk and bone loss in men undergoing androgen deprivation therapy for non-metastatic prostate cancer: implementation of standardized management guidelines
AS Cheung, D Pattison, I Bretherton, R Hoermann, D Lim Joon, E Ho, T Jenkins, EJ Hamilton, K Bate, I Chan, JD Zajac, M Grossmann
Our objective was to evaluate the effectiveness of implementing standardized guidelines to mitigate metabolic and bone side effect..