CONTROL OF MUSCULOSKELETAL FUNCTION AND INSULIN RESISTANCE BY ANDROGENS IN MALES

Grant number: 1024139 | Funding period: 2012 - 2015

Completed

Abstract

Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases general well being and contributes to muscle weakness, bone fragility and weight gain. By using cutting edge imaging and molecular technologies, we will help to explain the underlying mechanisms of how AD leads to these negative effects. This should ultimately lead to reduction of adverse outcomes of AD, which include fractures and cardiovascular events.

Related publications (35)

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Ada S Cheung, Rudolf Hoermann, Jasmine Zhu, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

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BACKGROUND: Animal studies suggest that undercarboxylated osteocalcin may improve insulin sensitivity via its effect on testicular..

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BACKGROUND: Obesity and dysglycemia (comprising insulin resistance, the metabolic syndrome and type 2 diabetes), that is diabesity..

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Biomechanical Leg Muscle Function During Stair Ambulation in Men Receiving Androgen Deprivation Therapy

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2020-09-01

BACKGROUND: The role of testosterone in maintaining functional performance in older men remains uncertain. METHODS: We conducted a..

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Differing Effects of Zoledronic Acid on Bone Microarchitecture and Bone Mineral Density in Men Receiving Androgen Deprivation Therapy: A Randomized Controlled Trial

Ada S Cheung, Rudolf Hoermann, Ali Ghasem-Zadeh, Alistair J Tinson, Vivian Ly, Stefan Milevski, Daryl Lim Joon, Jeffrey D Zajac, Ego Seeman, Mathis Grossmann

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Androgen deprivation therapy (ADT) given to men with prostate cancer causes rapid and severe sex steroid deficiency, leading to in..

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Testicular volume and clinical correlates of hypothalamic-pituitary-testicular function: A cross-sectional study in obese men

Mark Ng Tang Fui, Rudolf Hoermann, Gary Wittert, Mathis Grossmann

2020-07-01

The aim of this study was to determine whether testicular volume is correlated with clinical and biochemical markers of hypothalam..

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A body shape index (ABSI) reflects body composition changes in response to testosterone treatment in obese men

Rudolf Hoermann, Mark Ng Tang Fui, Jesse C Krakauer, Nir Y Krakauer, Mathis Grossmann

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BACKGROUND: Interventions such as testosterone treatment may change body composition and metabolic outcomes without substantial ch..

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Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy

Ada S Cheung, Christopher Cunningham, Dong-Kyoon Daniel Ko, Vivian Ly, Hans Gray, Rudolf Hoermann, Boyd JG Strauss, Ebrahim Bani Hassan, Gustavo Duque, Peter Ebeling, Marcus G Pandy, Jeffrey D Zajac, Mathis Grossmann

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CONTEXT: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walk..

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Persisting adverse body composition changes 2 years after cessation of androgen deprivation therapy for localised prostate cancer

Ada S Cheung, Alistair J Tinson, Stefan Milevski, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann

2018-07-01

OBJECTIVE: Hypogonadism from androgen deprivation therapy (ADT) for prostate cancer causes adverse body composition changes associ..

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Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer

Ada S Cheung, Casey de Rooy, Itamar Levinger, Kesha Rana, Michele V Clarke, Jackie M How, Andrew Garnham, Catriona McLean, Jeffrey D Zajac, Rachel A Davey, Mathis Grossmann

2017-11-01

Androgen deprivation therapy (ADT) decreases muscle mass and function but no human studies have investigated the underlying geneti..

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Effects of androgen deprivation therapy on telomere length

Ada S Cheung, Bu B Yeap, Rudolf Hoermann, Jennie Hui, John P Beilby, Mathis Grossmann

2017-10-01

OBJECTIVE: Recent evidence suggests that androgens either directly or via aromatisation to oestradiol may regulate telomere length..

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The effects of testosterone on body composition in obese men are not sustained after cessation of testosterone treatment

Mark Ng Tang Fui, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann

2017-10-01

BACKGROUND: Testosterone treatment in obese dieting men augments the diet-associated loss of fat mass, but protects against loss o..

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Hypothalamic-Pituitary-Thyroid Axis Set Point Alterations Are Associated With Body Composition in Androgen-Deprived Men

Rudolf Hoermann, Ada S Cheung, Michele Milne, Mathis Grossmann

2017-07-01

OBJECTIVE: Androgen deprivation therapy (ADT) given to men with prostate cancer is associated with metabolically adverse changes i..

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Effect of Testosterone Treatment on Adipokines and Gut Hormones in Obese Men on a Hypocaloric Diet

Ng Tang Fui Mark, Rudolf Hoermann, Mathis Grossmann

2017-04-01

CONTEXT: In obese men with lowered testosterone levels, testosterone treatment augments diet-associated loss of body fat. OBJECTIV..

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Quality of life decrements in men with prostate cancer undergoing androgen deprivation therapy

Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

2017-03-01

OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with decreased quality of life (QoL), controlled prospecti..

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Symptomatic response to testosterone treatment in dieting obese men with low testosterone levels in a randomized, placebo-controlled clinical trial

M Ng Tang Fui, R Hoermann, La Prendergast, Jd Zajac, M Grossmann

2017-03-01

BACKGROUND: Obese men commonly have reductions in circulating testosterone and report symptoms consistent with androgen deficiency..

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Androgen deprivation causes selective deficits in the biomechanical leg muscle function of men during walking: a prospective case-control study

Ada S Cheung, Hans Gray, Anthony G Schache, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann

2017-02-01

BACKGROUND: Although muscle mass declines with testosterone deficiency in men, previous studies of muscle function have not demons..

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Testosterone therapy increases muscle mass in men with cirrhosis and low testosterone: A randomised controlled trial

Marie Sinclair, Mathis Grossmann, Rudolf Hoermann, Peter W Angus, Paul J Gow

2016-11-01

BACKGROUND & AIMS: Low testosterone and sarcopenia are common in men with cirrhosis and both are associated with increased mortali..

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Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial

Mark Ng Tang Fui, Luke A Prendergast, Philippe Dupuis, Manjri Raval, Boyd J Strauss, Jeffrey D Zajac, Mathis Grossmann

2016-10-07

BACKGROUND: Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. ..

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Relationships between insulin resistance and frailty with body composition and testosterone in men undergoing androgen deprivation therapy for prostate cancer

Ada S Cheung, Rudolf Hoermann, Philippe Dupuis, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

2016-09-01

OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with insulin resistance and frailty, controlled prospectiv..

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Correlation of visceral adipose tissue measured by Lunar Prodigy dual X-ray absorptiometry with MRI and CT in older men

AS Cheung, C de Rooy, R Hoermann, EJ Gianatti, EJ Hamilton, G Roff, JD Zajac, M Grossmann

2016-08-01

Quantification of abdominal visceral adipose tissue (VAT) is important to understand obesity-related comorbidities. We hypothesize..

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Association of sex hormone-binding globulin and free testosterone with mortality in men with type 2 diabetes mellitus

Aye N Tint, Rudolf Hoermann, Henry Wong, Elif I Ekinci, Richard J MacIsaac, George Jerums, Jeffrey D Zajac, Mathis Grossmann

2016-01-01

OBJECTIVE: Low circulating testosterone levels have been associated with increased mortality in men. We hypothesized that the prog..

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Effect of testosterone treatment on cardiac biomarkers in a randomized controlled trial of men with type 2 diabetes

Emily J Gianatti, Rudolf Hoermann, Que Lam, Philippe Dupuis, Jeffrey D Zajac, Mathis Grossmann

2016-01-01

OBJECTIVE: To assess the effect of testosterone treatment on cardiac biomarkers in men with type 2 diabetes (T2D). DESIGN: Randomi..

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2016-01-01

Androgen deprivation therapy (ADT) is a highly effective treatment used in ∼30% of men with prostate cancer. Adverse effects of AD..

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Effects of testosterone treatment on glucose metabolism and symptoms in men with type 2 diabetes and the metabolic syndrome: a systematic review and meta-analysis of randomized controlled clinical trials

Mathis Grossmann, Rudolf Hoermann, Gary Wittert, Bu B Yeap

2015-09-01

CONTEXT: The effects of testosterone treatment on glucose metabolism and other outcomes in men with type 2 diabetes (T2D) and/or t..

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Sex steroids levels in chronic kidney disease and kidney transplant recipients: associations with disease severity and prediction of mortality

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2014-10-01

Prostate cancer and treatment with androgen deprivation therapy (ADT) affect significant numbers of the male population. Endocrine..

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Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial

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2014-08-01

OBJECTIVE: To determine whether testosterone therapy improves glucose metabolism in men with type 2 diabetes (T2D) and lowered tes..

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Lowered testosterone in male obesity: mechanisms, morbidity and management

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With increasing modernization and urbanization of Asia, much of the future focus of the obesity epidemic will be in the Asian regi..

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Testosterone and glucose metabolism in men: current concepts and controversies

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A wealth of observational studies show that low testosterone is associated with insulin resistance and with an increased risk of d..

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Obesity and age as dominant correlates of low testosterone in men irrespective of diabetes status

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Although men with type 2 diabetes (T2D) frequently have lowered testosterone levels, it is not well established whether this is as..

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Androgens and prostate cancer; pathogenesis and deprivation therapy

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2013-08-01

Although androgen receptor signaling is critical for prostate cancer growth and survival, evidence supporting a favorable risk-ben..

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Cardiovascular risk and bone loss in men undergoing androgen deprivation therapy for non-metastatic prostate cancer: implementation of standardized management guidelines

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Our objective was to evaluate the effectiveness of implementing standardized guidelines to mitigate metabolic and bone side effect..

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Metabolic disorders such as diabetes, obesity and the metabolic syndrome have been shown to modulate prostate cancer (PCa) risk an..

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Hematological changes during androgen deprivation therapy

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Androgen deprivation therapy (ADT) has been associated with a plethora of adverse effects, consistent with the androgen dependency..

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