STROKE IMAGING - IMPROVING PATIENT SELECTION FOR TREATMENT

Endovascular Thrombectomy Versus Medical Management in Isolated M2 Occlusions: Pooled Patient-Level Analysis from the EXTEND-IA Trials, INSPIRE, and SELECT Studies

Amrou Sarraj, Mark Parsons, Andrew Bivard, Ameer E Hassan, Michael G Abraham, Teddy Wu, Timothy Kleinig, Longting Lin, Chushuang Chen, Christopher Levi, Qiang Dong, Xin Cheng, Ken S Butcher, Philip Choi, Nawaf Yassi, Darshan Shah, Gagan Sharma, Deep Pujara, Faris Shaker, Spiros Blackburn

2022-03-17

OBJECTIVE: The objective of this study was to evaluate functional and safety outcomes of endovascular thrombectomy (EVT) versus me..

Prevalence and Significance of Impaired Microvascular Tissue Reperfusion Despite Macrovascular Angiographic Reperfusion (No-Reflow)

Felix C Ng, Leonid Churilov, Nawaf Yassi, Timothy John Kleinig, Vincent Thijs, Teddy Wu, Darshan Shah, Helen Dewey, Gagan Sharma, Patricia Desmond, Bernard Yan, Mark Parsons, Geoffrey Donnan, Stephen Davis, Peter Mitchell, Bruce Campbell

2022-02-22

BACKGROUND AND OBJECTIVES: The relevance of impaired microvascular tissue-level reperfusion despite complete upstream macrovascula..

Does Intravenous Thrombolysis Within 4.5 to 9 Hours Increase Clot Migration Leading to Endovascular Inaccessibility?

Jeremy C Lim, Leonid Churilov, Andrew Bivard, Henry Ma, Richard J Dowling, Bruce C Campbell, Mark W Parsons, Stephen M Davis, Geoffrey A Donnan, Peter J Mitchell, Bernard Yan

2021-03-01

BACKGROUND AND PURPOSE: Distal clot migration is a recognized event following intravenous thrombolysis (IVT) in the setting of acu..

Cost-Effectiveness of Tenecteplase Before Thrombectomy for Ischemic Stroke

Lan Gao, Marj Moodie, Peter J Mitchell, Leonid Churilov, Timothy J Kleinig, Nawaf Yassi, Bernard Yan, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis, Bruce CV Campbell

2020-12-01

BACKGROUND AND PURPOSE: Tenecteplase improved functional outcomes and reduced the requirement for endovascular thrombectomy in isc..

Association of Reperfusion After Thrombolysis With Clinical Outcome Across the 4.5-to 9-Hours and Wake-Up Stroke Time Window A Meta-Analysis of the EXTEND and EPITHET Randomized Clinical Trials

Bruce CV Campbell, Henry Ma, Mark W Parsons, Leonid Churilov, Nawaf Yassi, Timothy J Kleinig, Chung Y Hsu, Helen M Dewey, Kenneth S Butcher, Bernard Yan, Patricia M Desmond, Tissa Wijeratne, Sami Curtze, P Alan Barber, Deidre A De Silva, Vincent Thijs, Christopher R Levi, Christopher F Bladin, Gagan Sharma, Andrew Bivard

2020-11-02

Importance Intravenous alteplase reduces disability after ischemic stroke in patients 4.5 to 9 hours after onset and with wake-up..

Stroke

Bruce CV Campbell, Pooja Khatri

2020-07-11

Stroke is a major cause of death and disability globally. Diagnosis depends on clinical features and brain imaging to differentiat..

SELECTing Patients With Large Ischemic Core Who May Benefit From Endovascular Reperfusion

Bruce CV Campbell

2019-10-01

Advances in stroke medicine

Bruce C Campbell

2019-05-01

In recent years, reperfusion therapies such as intravenous thrombolysis and endovascular thrombectomy for ischaemic stroke have dr..

Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Bruce CV Campbell, Charles BLM Majoie, Gregory W Albers, Bijoy K Menon, Nawaf Yassi, Gagan Sharma, Wim H van Zwam, Robert J van Oostenbrugge, Andrew M Demchuk, Francis Guillemin, Philip White, Antoni Davalos, Aad van der Lugt, Kenneth S Butcher, Aboubaker Cherifi, Henk A Marquering, Geoffrey Cloud, Juan M Macho Fernandez, Jeremy Madigan, Catherine Oppenheim

2019-01-01

BACKGROUND: CT perfusion (CTP) and diffusion or perfusion MRI might assist patient selection for endovascular thrombectomy. We aim..

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke

BCV Campbell, PJ Mitchell, L Churilov, N Yassi, TJ Kleinig, RJ Dowling, B Yan, SJ Bush, HM Dewey, V Thijs, R Scroop, M Simpson, M Brooks, H Asadi, TY Wu, DG Shah, T Wijeratne, T Ang, F Miteff, CR Levi

2018-04-26

BACKGROUND: Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy for ischemic stroke. Tenec..

Endovascular Thrombectomy for Ischemic Stroke Increases Disability-Free Survival, Quality of Life, and Life Expectancy and Reduces Cost

Bruce CV Campbell, Peter J Mitchell, Leonid Churilov, Mahsa Keshtkaran, Keun-Sik Hong, Timothy J Kleinig, Helen M Dewey, Nawaf Yassi, Bernard Yan, Richard J Dowling, Mark W Parsons, Teddy Y Wu, Mark Brooks, Marion A Simpson, Ferdinand Miteff, Christopher R Levi, Martin Krause, Timothy J Harrington, Kenneth C Faulder, Brendan S Steinfort

2017-12-14

BACKGROUND: Endovascular thrombectomy improves functional outcome in large vessel occlusion ischemic stroke. We examined disabilit..

Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke

Bruce CV Campbell, Geoffrey A Donnan, Kennedy R Lees, Werner Hacke, Pooja Khatri, Michael D Hill, Mayank Goyal, Peter J Mitchell, Jeffrey L Saver, Hans-Christoph Diener, Stephen M Davis

2015-08-01

BACKGROUND: Results of initial randomised trials of endovascular treatment for ischaemic stroke, published in 2013, were neutral b..

Endovascular Therapy Proven for Stroke - Finally!

Bruce CV Campbell, Peter J Mitchell, Richard J Dowling, Bernard Yan, Geoffrey A Donnan, Stephen M Davis

2015-08-01

Cardiologists often remark that the field of ischaemic stroke follows in the footsteps of cardiology, just one to two decades late..

Twenty-Year History of the Evolution of Stroke Thrombolysis With Intravenous Alteplase to Reduce Long-Term Disability

Bruce CV Campbell, Atte Meretoja, Geoffrey A Donnan, Stephen M Davis

2015-08-01

State of Acute Endovascular Therapy Report From the 12th Thrombolysis, Thrombectomy, and Acute Stroke Therapy Conference

Pooja Khatri, Werner Hacke, Jens Fiehler, Jeffrey L Saver, Hans-Christoph Diener, Martin Bendszus, Serge Bracard, Joseph Broderick, Bruce Campbell, Alfonso Ciccone, Antoni Davalos, Stephen Davis, Andrew M Demchuk, Diederik Dippel, Geoffrey Donnan, David Fiorella, Mayank Goyal, Michael D Hill, Edward C Jauch, Tudor G Jovin

2015-06-01

Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection

BCV Campbell, PJ Mitchell, TJ Kleinig, HM Dewey, L Churilov, N Yassi, B Yan, RJ Dowling, MW Parsons, TJ Oxley, TY Wu, M Brooks, MA Simpson, F Miteff, CR Levi, M Krause, TJ Harrington, KC Faulder, BS Steinfort, M Priglinger

2015-03-12

BACKGROUND: Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test whe..

Imaging selection in ischemic stroke: feasibility of automated CT-perfusion analysis

Bruce CV Campbell, Nawaf Yassi, Henry Ma, Gagan Sharma, Simon Salinas, Leonid Churilov, Atte Meretoja, Mark W Parsons, Patricia M Desmond, Maarten G Lansberg, Geoffrey A Donnan, Stephen M Davis

2015-01-01

BACKGROUND: Advanced imaging may refine patient selection for ischemic stroke treatment but delays to acquire and process the imag..

Helsinki model cut stroke thrombolysis delays to 25 minutes in Melbourne in only 4 months

Atte Meretoja, Louise Weir, Melissa Ugalde, Nawaf Yassi, Bernard Yan, Peter Hand, Melinda Truesdale, Stephen M Davis, Bruce CV Campbell

2013-09-17

OBJECTIVE: To test the transferability of the Helsinki stroke thrombolysis model that achieved a median 20-minute door-to-needle t..

Failure of collateral blood flow is associated with infarct growth in ischemic stroke

Bruce CV Campbell, Soren Christensen, Brian M Tress, Leonid Churilov, Patricia M Desmond, Mark W Parsons, P Alan Barber, Christopher R Levi, Christopher Bladin, Geoffrey A Donnan, Stephen M Davis

2013-08-01

Changes in collateral blood flow, which sustains brain viability distal to arterial occlusion, may impact infarct evolution but ha..

CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke

Bruce CV Campbell, Louise Weir, Patricia M Desmond, Hans TH Tu, Peter J Hand, Bernard Yan, Geoffrey A Donnan, Mark W Parsons, Stephen M Davis

2013-06-01

BACKGROUND AND OBJECTIVE: CT perfusion (CTP) is rapid and accessible for emergency ischaemic stroke diagnosis. The feasibility of ..

Advanced imaging improves prediction of hemorrhage after stroke thrombolysis

Bruce CV Campbell, Soren Christensen, Mark W Parsons, Leonid Churilov, Patricia M Desmond, P Alan Barber, Kenneth S Butcher, Christopher R Levi, Deidre A De Silva, Maarten G Lansberg, Michael Mlynash, Jean-Marc Olivot, Matus Straka, Roland Bammer, Gregory W Albers, Geoffrey A Donnan, Stephen M Davis

2013-04-01

OBJECTIVE: Very low cerebral blood volume (VLCBV), diffusion, and hypoperfusion lesion volumes have been proposed as predictors of..

Comparison of Computed Tomography Perfusion and Magnetic Resonance Imaging Perfusion-Diffusion Mismatch in Ischemic Stroke

Bruce CV Campbell, Soren Christensen, Christopher R Levi, Patricia M Desmond, Geoffrey A Donnan, Stephen M Davis, Mark W Parsons

2012-10-01

BACKGROUND AND PURPOSE: Perfusion imaging has the potential to select patients most likely to respond to thrombolysis. We tested t..