Cell Pedigree Tracking To Elucidate How Polarity Proteins Alter Fate In C-Myc-Induced B Cell Lymphomas

Grant number: 1035991 | Funding period: 2012 - 2015

Completed

Abstract

During the onset of cancer, the orientation of cells is lost. My research project aims to determine the cellular and molecular basis by which proteins responsible for the orientation of cells are involved in leukaemia. Additionally, my work will investigate whether or not all proteins are equally distributed during cell division in B cell development, and will provide a platform for further investigation into how protein distribution might orchestrate fate decisions during development and leukaemia.