Grant number: 1020737 | Funding period: 2012 - 2016
I am a neuroscientist, studying fundamental mechanisms related to addiction. A major feature of my research is the neuropharmacological characterisation of potential novel therapeutic strategies to combat drug-seeking behaviour.
Related publications (36)
The persistence of growth impairments associated with adolescent inhalant abuse following sustained abstinence
Rose Crossin, Sheree Cairney, Andrew John Lawrence, Jhodie Rubina Duncan
Background: Abuse of inhalants containing the volatile solvent toluene is a significant public health issue, especially for adoles..
Nucleus incertus corticotrophin-releasing factor 1 receptor signalling regulates alcohol seeking in rats
Leigh C Walker, Hanna E Kastman, Jan A Koeleman, Craig M Smith, Christina J Perry, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence
Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly respon..
Extinction of conditioned cues attenuates incubation of cocaine craving in adolescent and adult rats.
Heather B Madsen, Isabel C Zbukvic, Sophia J Luikinga, Andrew J Lawrence, Jee Hyun Kim
Relapse to drug use is often precipitated by exposure to drug associated cues that evoke craving. Cue-induced drug craving has bee..
Aripiprazole Facilitates Extinction of Conditioned Fear in Adolescent Rats
Despina E Ganella, Liubov Lee-Kardashyan, Sophia J Luikinga, Danny LD Nguyen, Heather B Madsen, Isabel C Zbukvic, Russell Coulthard, Andrew J Lawrence, Jee Hyun Kim
Anxiety disorders are the most common type of mental disorder during adolescence, which is at least partly due to the resistance t..
Addiction-like Synaptic Impairments in Diet-Induced Obesity
Robyn Mary Brown, Yonatan Michael Kupchik, Sade Spencer, Constanza Garcia-Keller, David C Spanswick, Andrew John Lawrence, Stephanie Elise Simonds, Danielle Joy Schwartz, Kelsey Ann Jordan, Thomas Clayton Jhou, Peter William Kalivas
BACKGROUND: There is increasing evidence that the pathological overeating underlying some forms of obesity is compulsive in nature..
MDMA-induced neurotoxicity of serotonin neurons involves autophagy and rilmenidine is protective against its pathobiology
Linda D Mercer, Gavin C Higgins, Chew L Lau, Andrew J Lawrence, Philip M Beart
Toxicity of 3,4-methylenedioxymethamphetamine (MDMA) towards biogenic amine neurons is well documented and in primate brain predom..
Prefrontal Dopaminergic Mechanisms of Extinction in Adolescence Compared to Adulthood in Rats
Isabel C Zbukvic, Chun Hui J Park, Despina E Ganella, Andrew J Lawrence, Jee Hyun Kim
Adolescents with anxiety disorders attain poorer outcomes following extinction-based treatment compared to adults. Extinction defi..
Adolescent inhalant abuse leads to other drug use and impaired growth; implications for diagnosis
Rose Crossin, Sheree Cairney, Andrew J Lawrence, Jhodie R Duncan
OBJECTIVE: Abuse of inhalants containing the volatile solvent toluene is a significant public health issue, especially for adolesc..
The Nicotinic alpha 6-Subunit Selective Antagonist bPiDI Reduces Alcohol Self-Administration in Alcohol-Preferring Rats
Jirawoot Srisontiyakul, Hanna E Kastman, Elena V Krstew, Piyarat Govitrapong, Andrew J Lawrence
Cigarettes and alcohol are the most abused substances in the world and are commonly co-abused. Nicotine primarily acts in the brai..
Toluene inhalation in adolescent rats reduces flexible behaviour in adulthood and alters glutamatergic and GABAergic signalling
Teri M Furlong, Jhodie R Duncan, Laura H Corbit, Caroline D Rae, Benjamin D Rowlands, Anthony D Maher, Fatima A Nasrallah, Carol J Milligan, Steven Petrou, Andrew J Lawrence, Bernard W Balleine
Toluene is a commonly abused inhalant that is easily accessible to adolescents. Despite the increasing incidence of use, our under..
Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice
Craig M Smith, Lesley L Walker, Tanawan Leeboonngam, Michael J McKinley, Derek A Denton, Andrew J Lawrence
Due to the importance of dietary sodium and its paucity within many inland environments, terrestrial animals have evolved an insti..
Nucleus incertus Orexin(2) receptors mediate alcohol seeking in rats
Hanna E Kastman, Anna Blasiak, Leigh Walker, Marcin Siwiec, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence
Alcoholism is a chronic relapsing disorder and a major global health problem. Stress is a key precipitant of relapse in human alco..
Knockdown of corticotropin-releasing factor 1 receptors in the ventral tegmental area enhances conditioned fear
Nicola A Chen, Despina E Ganella, Ross AD Bathgate, Alon Chen, Andrew J Lawrence, Jee Hyun Kim
The neuropeptide corticotropin-releasing factor (CRF) coordinates the physiological and behavioural responses to stress. CRF recep..
Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats
Isabel C Zbukvic, Despina E Ganella, Christina J Perry, Heather B Madsen, Christopher R Bye, Andrew J Lawrence, Jee Hyun Kim
Adolescent drug users display resistance to treatment such as cue exposure therapy (CET), as well as increased liability to relaps..
Chronic intermittent toluene inhalation in adolescent rats results in metabolic dysfunction with altered glucose homeostasis
ALW Dick, A Simpson, A Qama, Z Andrews, AJ Lawrence, JR Duncan
BACKGROUND AND PURPOSE: Abuse of toluene-containing inhalants is an increasing public health problem, especially among adolescents..
NMDA receptor binding is reduced within mesocorticolimbic regions following chronic inhalation of toluene in adolescent rats
Alec Lindsay Ward Dick, Tine Pooters, Sarah Gibbs, Emma Giles, Ashleigh Qama, Andrew John Lawrence, Jhodie Rubina Duncan
The purposeful inhalation of volatile solvents, such as toluene, to induce self-intoxication is prevalent, particularly within ado..
Involvement of central relaxin-3 signalling in sodium (salt) appetite
Craig M Smith, Lesley L Walker, Berenice E Chua, Michael J McKinley, Andrew L Gundlach, Derek A Denton, Andrew J Lawrence
NEW FINDINGS: What is the central question of this study? Sodium appetite is controlled by conserved neuronal transmitter-receptor..
Relaxin-3 Receptor (RXFP3) Signalling Mediates Stress-Related Alcohol Preference in Mice
Andrew W Walker, Craig M Smith, Berenice E Chua, Elena V Krstew, Cary Zhang, Andrew L Gundlach, Andrew J Lawrence
Stressful life events are causally linked with alcohol use disorders (AUDs), providing support for a hypothesis that alcohol consu..
DISTRIBUTION OF OREXIN-1 RECEPTOR-GREEN FLUORESCENT PROTEIN- (OX1-GFP) EXPRESSING NEURONS IN THE MOUSE BRAIN STEM AND PONS: CO-LOCALIZATION WITH TYROSINE HYDROXYLASE AND NEURONAL NITRIC OXIDE SYNTHASE
A Darwinkel, D Stanic, LC Booth, CN May, AJ Lawrence, ST Yao
We used a reporter mouse line in which green fluorescent protein (GFP) was inserted into the orexin-1 receptor (OX1) locus to syst..
Chronic intermittent toluene inhalation initiated during adolescence in rats does not alter voluntary consumption of ethanol in adulthood
Alec LW Dick, Andrew J Lawrence, Jhodie R Duncan
Voluntary inhalation of organic solvents, such as toluene, is particularly prevalent in adolescent populations and is considered t..
Specific impairments in instrumental learning following chronic intermittent toluene inhalation in adolescent rats
Alec LW Dick, Martin Axelsson, Andrew J Lawrence, Jhodie R Duncan
RATIONALE: Inhalant abuse is prevalent in adolescent populations, with chronic use resulting in neurobiological and cognitive abno..
The mGlu5 receptor regulates extinction of cocaine-driven behaviours
Michael K Bird, Peter Lohmann, Billy West, Robyn M Brown, Jeppe Kirchhoff, Clarke R Raymond, Andrew J Lawrence
BACKGROUND: There is extensive evidence implicating the metabotropic glutamate 5 (mGlu5) receptor in aspects of addiction-related ..
Chronic intermittent toluene inhalation in adolescent rats alters behavioural responses to amphetamine and MK801
Jhodie Rubina Duncan, Sarah Jane Gibbs, Andrew John Lawrence
Abuse of toluene-containing inhalants is common during adolescence, with ongoing chronic misuse associated with adverse outcomes a..
An improved method to prepare an injectable microemulsion of the galanin-receptor 3 selective antagonist, SNAP 37889, using Kolliphor(®) HS 15.
Karlene J Scheller, Spencer J Williams, Andrew J Lawrence, Bevyn Jarrott, Elvan Djouma
Research into the galanin-3 (GAL3) receptor has many challenges, including the lack of commercially available selective ligands. W..
Maternally Administered Sustained-Release Naltrexone in Rats Affects Offspring Neurochemistry and Behaviour in Adulthood
Waleed O Farid, Andrew J Lawrence, Elena V Krstew, Robert J Tait, Gary K Hulse, Sarah A Dunlop
Naltrexone is not recommended during pregnancy. However, sustained-release naltrexone implant use in humans has resulted in cases ..
Adolescent Toluene Inhalation in Rats Affects White Matter Maturation with the Potential for Recovery Following Abstinence
Jhodie Rubina Duncan, Alec Lindsay Ward Dick, Gary Egan, Scott Kolbe, Maria Gavrilescu, David Wright, Dan Ian Lubman, Andrew John Lawrence
Inhalant misuse is common during adolescence, with ongoing chronic misuse associated with neurobiological and cognitive abnormalit..
Investigation of the neuroanatomical substrates of reward seeking following protracted abstinence in mice
Heather B Madsen, Robyn M Brown, Jennifer L Short, Andrew J Lawrence
Persistent vulnerability to relapse represents a major challenge in the treatment of drug addiction. The brain circuitry that unde..