RESEARCH FELLOWSHIP

Grant number: 1020401 | Funding period: 2012 - 2016

Completed

Abstract

My research focuses on understanding pathobiological mechanisms in acute and chronic neurodegenerative conditions such as stroke and Parkinson’s disease which have large burdens on the community through health care costs and on families because of the lack of effective treatments. An improved understanding of how brain cells die and of how the most abundant brain cell, the astrocyte, can be engineered to be a resource for regenerative medicine offer promise for improved clinical management.

Related publications (11)

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Inhibition of bioenergetics provides novel insights into recruitment of PINK1-dependent neuronal mitophagy

Yea Seul Shin, James G Ryall, Joanne M Britto, Chew L Lau, Rodney J Devenish, Phillip Nagley, Philip M Beart

2019-04-01

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A Programmed Anti-Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response

Francesca L Maclean, Georgina M Ims, Malcolm K Horne, Richard J Williams, David R Nisbet

2018-12-13

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Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells

Tong Chen, Bradley J Turner, Philip M Beart, Lucy Sheehan-Hennessy, Chinasom Elekwachi, Hakan Muyderman

2018-01-01

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Reducing Astrocytic Scarring after Traumatic Brain Injury with a Multifaceted Anti-Inflammatory Hydrogel System

Francesca L Maclean, Yi Wang, Rohan Walker, Malcolm K Horne, Richard J Williams, David R Nisbet

2017-10-01

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Galactose-functionalised PCL nanofibre scaffolds to attenuate inflammatory action of astrocytes in vitro and in vivo

Francesca L Maclean, Chew L Lau, Sam Ozergun, Ross D O'Shea, Cecilia Cederfur, Jason Wang, Kevin E Healy, Frederick R Walker, Doris Tomas, Malcolm K Horne, Philip M Beart, David R Nisbet

2017-06-14

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MDMA-induced neurotoxicity of serotonin neurons involves autophagy and rilmenidine is protective against its pathobiology

Linda D Mercer, Gavin C Higgins, Chew L Lau, Andrew J Lawrence, Philip M Beart

2017-05-01

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Synaptic signalling and its interface with neuropathologies: snapshots from the past, present and future

Philip M Beart

2016-10-01

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A Commentary on the Need for 3D-Biologically Relevant In Vitro Environments to Investigate Astrocytes and Their Role in Central Nervous System Inflammation

FL Maclean, RJ Williams, MK Horne, DR Nisbet

2016-03-01

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Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis

Ross D O'Shea, Chew L Lau, Natasha Zulaziz, Francesca L Maclean, David R Nisbet, Malcolm K Home, Philip M Beart

2015-02-20

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3D Electrospun scaffolds promote a cytotrophic phenotype of cultured primary astrocytes

Chew L Lau, Michelle Kovacevic, Tine S Tingleff, John S Forsythe, Holly S Cate, Daniel Merlo, Cecilia Cederfur, Francesca L Maclean, Clare L Parish, Malcolm K Horne, David R Nisbet, Philip M Beart

2014-07-01

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Gene profiling identifies commonalities in neuronal pathways in excitotoxicity: Evidence favouring cell cycle re-activation in concert with oxidative stress

Minghui Jessica Chen, Jian Ming Jeremy Ng, Zhao Feng Peng, Jayapal Manikandan, Yann Wan Yap, Roxana M Llanos, Philip M Beart, Nam Sang Cheung

2013-04-01

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