Grant number: 1020401 | Funding period: 2012 - 2016
My research focuses on understanding pathobiological mechanisms in acute and chronic neurodegenerative conditions such as stroke and Parkinson’s disease which have large burdens on the community through health care costs and on families because of the lack of effective treatments. An improved understanding of how brain cells die and of how the most abundant brain cell, the astrocyte, can be engineered to be a resource for regenerative medicine offer promise for improved clinical management.
Related publications (11)
Inhibition of bioenergetics provides novel insights into recruitment of PINK1-dependent neuronal mitophagy
Yea Seul Shin, James G Ryall, Joanne M Britto, Chew L Lau, Rodney J Devenish, Phillip Nagley, Philip M Beart
Contributions of damaged mitochondria to neuropathologies have stimulated interest in mitophagy. We investigated triggers of neuro..
A Programmed Anti-Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response
Francesca L Maclean, Georgina M Ims, Malcolm K Horne, Richard J Williams, David R Nisbet
Immunology is the next frontier of nano/biomaterial science research, with the immune system determining the degree of tissue repa..
Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells
Tong Chen, Bradley J Turner, Philip M Beart, Lucy Sheehan-Hennessy, Chinasom Elekwachi, Hakan Muyderman
Oxidative stress is recognised as central in a range of neurological diseases including Amyotrophic lateral sclerosis (ALS), a dis..
Reducing Astrocytic Scarring after Traumatic Brain Injury with a Multifaceted Anti-Inflammatory Hydrogel System
Francesca L Maclean, Yi Wang, Rohan Walker, Malcolm K Horne, Richard J Williams, David R Nisbet
Traumatic brain injury results in devastating long-term functional damage due to the growth inhibition of the inflammatory respons..
Galactose-functionalised PCL nanofibre scaffolds to attenuate inflammatory action of astrocytes in vitro and in vivo
Francesca L Maclean, Chew L Lau, Sam Ozergun, Ross D O'Shea, Cecilia Cederfur, Jason Wang, Kevin E Healy, Frederick R Walker, Doris Tomas, Malcolm K Horne, Philip M Beart, David R Nisbet
Astrocytes represent an attractive therapeutic target for the treatment of traumatic brain injury in the glial scar, which inhibit..
MDMA-induced neurotoxicity of serotonin neurons involves autophagy and rilmenidine is protective against its pathobiology
Linda D Mercer, Gavin C Higgins, Chew L Lau, Andrew J Lawrence, Philip M Beart
Toxicity of 3,4-methylenedioxymethamphetamine (MDMA) towards biogenic amine neurons is well documented and in primate brain predom..
A Commentary on the Need for 3D-Biologically Relevant In Vitro Environments to Investigate Astrocytes and Their Role in Central Nervous System Inflammation
FL Maclean, RJ Williams, MK Horne, DR Nisbet
Astrocytes execute essential functions in the healthy CNS, whilst also being implicated as a limitation to functional regeneration..
Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis
Ross D O'Shea, Chew L Lau, Natasha Zulaziz, Francesca L Maclean, David R Nisbet, Malcolm K Home, Philip M Beart
Astrocytes provide trophic, structural and metabolic support to neurons, and are considered genuine targets in regenerative neurob..
3D Electrospun scaffolds promote a cytotrophic phenotype of cultured primary astrocytes
Chew L Lau, Michelle Kovacevic, Tine S Tingleff, John S Forsythe, Holly S Cate, Daniel Merlo, Cecilia Cederfur, Francesca L Maclean, Clare L Parish, Malcolm K Horne, David R Nisbet, Philip M Beart
Astrocytes are a target for regenerative neurobiology because in brain injury their phenotype arbitrates brain integrity, neuronal..
Gene profiling identifies commonalities in neuronal pathways in excitotoxicity: Evidence favouring cell cycle re-activation in concert with oxidative stress
Minghui Jessica Chen, Jian Ming Jeremy Ng, Zhao Feng Peng, Jayapal Manikandan, Yann Wan Yap, Roxana M Llanos, Philip M Beart, Nam Sang Cheung
Excitotoxicity, induced by the aberrant rise in cytosolic Ca(2+) level, is a major neuropathological process in numerous neurodege..