Redox Sulfur Chemistry in Copper Nutrition
Grant number: DP120100752 | Funding period: 2012 - 2015
Problems with metabolism of the nutrient metal copper are associated with many diseases including tuberculosis, heart disease and Alzheimer's disease. The project will examine the role of copper in unprecedented molecular detail to better understand its influence on normal metabolism and hence its impact on the diseases.
Related publications (1)
Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG/2GSH and the availability of Cu(I)
Jens Brose, Sharon La Fontaine, Anthony G Wedd, Zhiguang Xiao
Glutaredoxins have been characterised as enzymes regulating the redox status of protein thiols via cofactors GSSG/GSH. However, su..