Common Synaptic Inputs to Human Upper Airway Muscles
Grant number: DP120101343 | Funding period: 2012 - 2015
Changes in the activity of upper airway muscles at sleep onset contribute to the development of Obstructive Sleep Apnoea. The aim of this project is to investigate how the brain controls upper airway muscles during wakefulness and sleep and to identify the pathological processes that lead to the development of Obstructive Sleep Apnoea.
Related publications (4)
Mechanisms of the deep, slow-wave, sleep-related increase of upper airway muscle tone in healthy humans
Amelia Hicks, Jennifer M Cori, Amy S Jordan, Christian L Nicholas, Leszek Kubin, John G Semmler, Atul Malhotra, David GP McSharry, John A Trinder
Upper airway muscle activity is reportedly elevated during slow-wave sleep (SWS) when compared with lighter sleep stages. To uncov..
Common drive to the upper airway muscle genioglossus during inspiratory loading
Michael J Woods, Christian L Nicholas, John G Semmler, Julia KM Chan, Amy S Jordan, John Trinder
Common drive is thought to constitute a central mechanism by which the efficiency of a motor neuron pool is increased. This study ..
Motor unit activity in upper airway muscles genioglossus and tensor palatini
John Trinder, Michael Woods, Christian L Nicholas, Julia KM Chan, Amy S Jordan, John G Semmler
Common oscillatory inputs to genioglossus (GG) and tensor palatini (TP) motoneurons were assessed using coherence analysis. Oscill..