Enhancing our Understanding of Metallochemistry in Neurobiology with Modern EPR Spectroscopy

Interplay between Copper, Neprilysin, and N-Truncation of beta-Amyloid

Mariusz Mital, Wojciech Bal, Tomasz Fraczyk, Simon C Drew

2018-06-04

The Case for Abandoning Therapeutic Chelation of Copper Ions Alzheimer's Disease

Simon C Drew

2017-06-02

A 2-Substituted 8-Hydroxyquinoline Stimulates Neural Stem Cell Proliferation by Modulating ROS Signalling

Cathryn L Haigh, Carolin Tumpach, Steven J Collins, Simon C Drew

2016-09-01

Copper Exchange and Redox Activity of a Prototypical 8-Hydroxyquinoline: Implications for Therapeutic Chelation

Mariusz Mital, Izabela A Zawisza, Magdalena Z Wiloch, Urszula E Wawrzyniak, Vijaya Kenche, Wojciech Wroblewski, Wojciech Bal, Simon C Drew

2016-08-01

Resistance of Cu(A beta 4-16) to Copper Capture by Metallothionein-3 Supports a Function for the A beta 4-42 Peptide as a Synaptic Cu-II Scavenger

Nina E Wezynfeld, Ewelina Stefaniak, Kinga Stachucy, Agnieszka Drozd, Dawid Plonka, Simon C Drew, Artur Krezel, Wojciech Bal

2016-07-11

On the ability of CuA beta(1-x) peptides to form ternary complexes: Neurotransmitter glutamate is a competitor while not a ternary partner

Tomasz Fraczyk, Izabela A Zawisza, Wojciech Goch, Ewelina Stefaniak, Simon C Drew, Wojciech Bal

2016-05-01

Probing the quaternary structure of metal-bridged peptide oligomers

Simon C Drew

2016-05-01

Tuning the Redox Properties of Copper(II) Complexes with Amyloid-beta Peptides

Magdalena Z Wiloch, Urszula E Wawrzyniak, Iwona Ufnalska, Arkadiusz Bonna, Wojciech Bal, Simon C Drew, Wojciech Wroblewskia

2016-01-01

A Functional Role for A in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding

Mariusz Mital, Nina E Wezynfeld, Tomasz Fraczyk, Magdalena Z Wiloch, Urszula E Wawrzyniak, Arkadiusz Bonna, Carolin Tumpach, Kevin J Barnham, Cathryn L Haigh, Wojciech Bal, Simon C Drew

2015-09-01

alpha-Synuclein and beta-Amyloid form a Bridged Copper Complex

Simon C Drew

2015-09-01

The Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection Responses

Cathryn L Haigh, Carolin Tumpach, Simon C Drew, Steven J Collins

2015-08-07

Cavitation during the protein misfolding cyclic amplification (PMCA) method - The trigger for de novo prion generation?

Cathryn L Haigh, Simon C Drew

2015-06-05

The N Terminus of alpha-Synuclein Forms Cu-II-Bridged Oligomers

Simon C Drew

2015-05-04

The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro

Steven J Collins, Carolin Tumpach, Qiao-Xin Li, Victoria Lewis, Timothy M Ryan, Blaine Roberts, Simon C Drew, Victoria A Lawson, Cathryn L Haigh

2015-04-11

Stable Radical Content and Anti-Radical Activity of Roasted Arabica Coffee: From In-Tact Bean to Coffee Brew

Gordon J Troup, Luciano Navarini, Furio Suggi Liverani, Simon C Drew

2015-04-09

Neutron Reflectometry Studies Define Prion Protein N-terminal Peptide Membrane Binding

Anton P Le Brun, Cathryn L Haigh, Simon C Drew, Michael James, Martin P Boland, Steven J Collins

2014-11-18

Blood vessel cell death during prion disease: Implications for disease management and infection control

Cathryn L Haigh, Victoria A Lawson, Simon C Drew

2014-11-01