Engineering Macromolecular Architectures for Targeted Applications
Grant number: FT110100411 | Funding period: 2012 - 2016
The purpose of the project is to use intelligent design to synthesise highly complex polymer architectures for targeted applications. The advances of this research will be expanded to target ultrathin gas separation membranes, self-assembling star polymers for drug delivery and fluorinated macromonomers for in-vivo biodistribution studies.
Related publications (59)
Blood-Catalyzed RAFT Polymerization
Amin Reyhani, Mitchell D Nothling, Hadi Ranji-Burachaloo, Thomas G McKenzie, Qiang Fu, Shereen Tan, Gary Bryant, Greg G Qiao
The use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via a reversible addition..
Biocompatible Porous Polyester-Ether Hydrogel Scaffolds with Cross-Linker Mediated Biodegradation and Mechanical Properties for Tissue Augmentation
Berkay Ozcelik, Jason Palmer, Katharina Ladewig, Paula Facal Marina, Geoffrey W Stevens, Keren Abberton, Wayne A Morrison, Anton Blencowe, Greg G Qiao
Porous polyester-ether hydrogel scaffolds (PEHs) were fabricated using acid chloride/alcohol chemistry and a salt templating appro..
Tuning the Properties of Polymer Capsules for Cellular Interactions
Huanli Sun, Jiwei Cui, Yi Ju, Xi Chen, Edgar HH Wong, Jenny Tran, Greg G Qiao, Frank Caruso
Particle-cell interactions are governed by, among other factors, the composition and surface properties of the particles. Herein, ..
Antifogging Surface Facilitated by Nanoscale Coatings with Controllable Hydrophobicity and Cross-Linking Density
Eunhyung Nam, Edgar HH Wong, Shereen Tan, Qiang Fu, Anton Blencowe, Greg G Qiao
Antifogging and frost-resistant coatings can be used in a wide range of applications and enable high light transmission through su..
Bionano Interaction Study on Antimicrobial Star-Shaped Peptide Polymer Nanoparticles
Shu J Lam, Edgar HH Wong, Neil M O'Brien-Simpson, Namfon Pantarat, Anton Blencowe, Eric C Reynolds, Greg G Qiao
'Structurally nanoengineered antimicrobial peptide polymers' (SNAPPs), in the form of star-shaped peptide polymer nanoparticles, h..
Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers
Shu J Lam, Neil M O'Brien-Simpson, Namfon Pantarat, Adrian Sulistio, Edgar HH Wong, Yu-Yen Chen, Jason C Lenzo, James A Holden, Anton Blencowe, Eric C Reynolds, Greg G Qiao
With the recent emergence of reports on resistant Gram-negative 'superbugs', infections caused by multidrug-resistant (MDR) Gram-n..
CO2 separation using surface-functionalized SiO2 nanoparticles incorporated ultra-thin film composite mixed matrix membranes for post-combustion carbon capture
Jinguk Kim, Qiang Fu, Ke Xie, Joel MP Scofield, Sandra E Kentish, Greg G Qiao
CO2 separation across polyethylene glycol (PEG)-based ultra-thin film composite mixed matrix membranes (UTFC-MMMs) containing surf..
Beyond Traditional RAFT: Alternative Activation of Thiocarbonylthio Compounds for Controlled Polymerization
Thomas G McKenzie, Qiang Fu, Mineto Uchiyama, Kotaro Satoh, Jiangtao Xu, Cyrille Boyer, Masami Kamigaito, Greg G Qiao
Recent developments in polymerization reactions utilizing thiocarbonylthio compounds have highlighted the surprising versatility o..
Blends of Fluorinated Additives with Highly Selective Thin-Film Composite Membranes to Increase CO2 Permeability for CO2/N-2 Gas Separation Applications
Joel MP Scofield, Paul A Gurr, Jinguk Kim, Qiang Fu, Sandra E Kentish, Greg G Qiao
A highly permeable poly(ethylene glycol-b-pentafluoropropyl acrylate) diblock copolymer additive is blended with the highly select..
Jing M Ren, Thomas G McKenzie, Qiang Fu, Edgar HH Wong, Jiangtao Xu, Zesheng An, Sivaprakash Shanmugam, Thomas P Davis, Cyrille Boyer, Greg G Qiao
Recent advances in controlled/living polymerization techniques and highly efficient coupling chemistries have enabled the facile s..
Polypeptide-Based Macroporous Cryogels with Inherent Antimicrobial Properties: The Importance of a Macroporous Structure
Steven J Shirbin, Shu J Lam, Nicholas Jun-An Chan, Mehmet Murat Ozmen, Qiang Fu, Neil O'Brien-Simpson, Eric C Reynolds, Greg G Qiao
Synthetic polypeptide-based macroporous cryogels with inherent antimicrobial properties were prepared for potential water purifica..
Photocontrolled Cargo Release from Dual Cross-Linked Polymer Particles
Shereen Tan, Jiwei Cui, Qiang Fu, Eunhyung Nam, Katharina Ladewig, Jing M Ren, Edgar HH Wong, Frank Caruso, Anton Blencowe, Greg G Qiao
Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. Th..
Stereoregular High-Density Bottlebrush Polymer and Its Organic Nanocrystal Stereocomplex through Triple-Helix Formation
JM Ren, K Ishitake, K Satoh, A Blencowe, Q Fu, EHH Wong, M Kamigaito, GG Qiao
We report the synthesis of a well-defined molecular bottlebrush polymer with stereoregular side chains (i.e., syndiotactic PMMA). ..
Development of Novel Fluorinated Additives for High Performance CO2 Separation Thin-film Composite Membranes
JMP Scofield, P Gurr, J Kim, Q Fu, null Kentish, G QIao
A series of poly(ethylene glycol)-block-poly(pentafluoropropyl acrylate) diblock copolymers were synthesized by Reversible Additio..
Investigation into the photolytic stability of RAFT agents and the implications for photopolymerization reactions
TG McKenzie, LP da M Costa, Q Fu, DE Dunstan, GG Qiao
The photolytic stability of various RAFT agents (i.e., thiocarbonylthio-containing compounds) under irradiation from a blue LED li..
Spatial-controlled nanoengineered films prepared via rapid catalyst induced cross-linking
Eunhyung Nam, Edgar HH Wong, Shereen Tan, Stefanie N Guntari, Qiang Fu, Jinguk Kim, Bahman Delalat, Anton Blencowe, Greg G Qiao
A new top-down approach to generate stable nanoscale films via catalyst induced cross-linking (CIC) is demonstrated. Polymers with..
Ultra-thin film composite mixed matrix membranes incorporating iron(III)-dopamine nanoparticles for CO2 separation
Jinguk Kim, Qiang Fu, Joel MP Scofield, Sandra E Kentish, Greg G Qiao
Iron dopamine nanoparticles (FeDA NPs) are incorporated into a nanoscale thick polyethylene glycol (PEG) matrix for the first time..
Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model
Huanli Sun, Mattias Bjoernmalm, Jiwei Cui, Edgar HH Wong, Yunlu Dai, Qiong Dai, Greg G Qiao, Frank Caruso
Particle stiffness is a design parameter that affects bionano interactions, including biodistribution kinetics and cellular proces..
Controlled Formation of Star Polymer Nanoparticles via Visible Light Photopolymerization
Thomas G McKenzie, Edgar HH Wong, Qiang Fu, Adrian Sulistio, Dave E Dunstan, Greg G Qiao
A recently developed visible light mediated photocontrolled radical polymerization technique using trithiocarbonates (i.e., conven..
Cisplatin-Induced Formation of Biocompatible and Biodegradable Polypeptide-Based Vesicles for Targeted Anticancer Drug Delivery
Steven J Shirbin, Katharina Ladewig, Qiang Fu, Molly Klimak, Xiaoqing Zhang, Wei Duan, Greg G Qiao
Novel cisplatin (CDDP)-loaded, polypeptide-based vesicles for the targeted delivery of cisplatin to cancer cells have been prepare..
Visible Light Mediated Controlled Radical Polymerization in the Absence of Exogenous Radical Sources or Catalysts
Thomas G McKenzie, Qiang Fu, Edgar HH Wong, Dave E Dunstan, Greg G Qiao
The application of external stimuli such as light to induce controlled radical polymerization reactions has important implications..
Functional and Well-Defined β-Sheet-Assembled Porous Spherical Shells by Surface-Guided Peptide Formation
SH Wibowo, A Sulistio, EHH Wong, A Blencowe, GG Qiao
Polypeptides have attracted widespread attention as building blocks for complex materials due to their ability to form higher-orde..
Amphiphilic core cross-linked star polymers as water-soluble, biocompatible and biodegradable unimolecular carriers for hydrophobic drugs
D Gu, K Ladewig, M Klimak, D Haylock, KM McLean, AJ O'Connor, GG Qiao
Unimolecular polymeric architectures are ideal candidates for drug encapsulation. In this study we report the facile yet well-cont..
Cyclodextrin-based supramolecular polymeric nanoparticles for next generation gas separation membranes
Shereen Tan, Qiang Fu, Joel MP Scofield, Jinguk Kim, Paul A Gurr, Katharina Ladewig, Anton Blencowe, Greg G Qiao
Cyclodextrin-based supramolecular assemblies derived from poly(dimethylsiloxane) (PDMS) functionalized polyrotaxanes (PRXs) were s..
Fabrication of ultra-thin polyrotaxane-based films via solid-state continuous assembly of polymers
Shereen Tan, Eunhyung Nam, Jiwei Cui, Chenglong Xu, Qiang Fu, Jing M Ren, Edgar HH Wong, Katharina Ladewig, Frank Caruso, Anton Blencowe, Greg G Qiao
Surface-confined ultra-thin polyrotaxane (PRX)-based films with tunable composition, surface topology and swelling characteristics..
Tertiary amine catalyzed photo-induced controlled radical polymerization of methacrylates
Qiang Fu, Thomas G McKenzie, Shereen Tan, Eunhyung Nam, Greg G Qiao
A novel tertiary amine catalyst (TAC) and trithiocarbonate (TTC) synergistic photo-induced controlled radical polymerization of me..
Highly Efficient and Versatile Formation of Biocompatible Star Polymers in Pure Water and Their Stimuli-Responsive Self-Assembly
Thomas G McKenzie, Edgar HH Wong, Qiang Fu, Shu Jie Lam, Dave E Dunstan, Greg G Qiao
This study demonstrates the rapid and efficient formation of functional core cross-linked star polymers via copper-mediated revers..
The effect of soft nanoparticle morphologies on thin film composite membrane performance
Qiang Fu, Edgar HH Wong, Jinguk Kim, Joel MP Scofield, Paul A Gurr, Sandra E Kentish, Greg G Qiao
Well-defined branched and densely cross-linked soft nanoparticles (SNPs) were synthesized and incorporated into a poly(ether-b-ami..
Fabrication of Chiral Stationary Phases via Continuous Assembly of Polymers for Resolution of Enantiomers by Liquid Chromatography
Stefanie N Guntari, Eunhyung Nam, Nina N Pranata, Kenneth Chia, Edgar HH Wong, A Blencowe, Tor K Goh, Frank Caruso, Greg G Qiao
Precise stereochemical determination of chiral molecules is highly important, especially in the pharmaceutical industry where one ..
Biodegradable and Biocompatible Poly(Ethylene Glycol)-based Hydrogel Films for the Regeneration of Corneal Endothelium
Berkay Ozcelik, Karl D Brown, Anton Blencowe, Katharina Ladewig, Geoffrey W Stevens, Jean-Pierre Y Scheerlinck, Keren Abberton, Mark Daniell, Greg G Qiao
Corneal endothelial cells (CECs) are responsible for maintaining the transparency of the human cornea. Loss of CECs results in bli..
Continuous assembly of polymers via solid phase reactions
Eunhyung Nam, Jinguk Kim, Stefanie N Guntari, Helga Seyler, Qiang Fu, Edgar HH Wong, Anton Blencowe, David J Jones, Frank Caruso, Greg G Qiao
The continuous assembly of polymers in the solid state via ring-opening metathesis polymerization (ssCAPROMP) is reported as an ef..
Highly porous and mechanically robust polyester poly(ethylene glycol) sponges as implantable scaffolds
Berkay Ozcelik, Anton Blencowe, Jason Palmer, Katharina Ladewig, Geoffrey W Stevens, Keren M Abberton, Wayne A Morrison, Greg G Qiao
The development of suitable scaffolds plays a significant role in tissue engineering research. Although scaffolds with promising f..
Soft Nanoparticles Assembled from Linear Poly( ethylene glycol) and Linear Brush Polydimethylsiloxane Diblock Copolymers
Andri Halim, Timothy D Reid, Jing M Ren, Qiang Fu, Paul A Gurr, Anton Blencowe, Sandra E Kentish, Greg G Qiao
A series of novel amphiphilic diblock copolymers composed of hydrophilic linear poly(ethylene glycol) (PEG) and linear brush hydro..
Soft polymeric nanoparticle additives for next generation gas separation membranes
Andri Halim, Qiang Fu, Qiwyn Yong, Paul A Gurr, Sandra E Kentish, Greg G Qiao
This article highlights a new approach of fabricating a gas separation membrane through the addition of well-defined soft polymeri..
(Super)hydrophobic and Multilayered Amphiphilic Films Prepared by Continuous Assembly of Polymers
Stefanie N Guntari, Aaron CH Khin, Edgar HH Wong, Tor K Goh, Anton Blencowe, Frank Caruso, Greg G Qiao
The continuous assembly of polymers (CAP) is used to fabricate tailored nanocoatings on a wide variety of substrates. Ring-opening..
Assembly of Nanostructured Films with Hydrophobic Subcompartments via Continuous Assembly of Polymers
Edgar HH Wong, Martin P van Koeverden, Eunhyung Nam, Stefanie N Guntari, Steven Harris Wibowo, Anton Blencowe, Frank Caruso, Greg G Qiao
The generation of nanoscale polymer films using complex, hierarchically structured (bio)macromolecular architectures has important..
Assembly of Free-Standing Polypeptide Films via the Synergistic Combination of Hyperbranched Macroinitiators, the Grafting-From Approach, and Cross-Chain Termination
Steven Harris Wibowo, Edgar HH Wong, Adrian Sulistio, Stefanie N Guntari, Anton Blencowe, Frank Caruso, Greg G Qiao
Cross-linked polypeptide-based films are fabricated via a novel and robust method employing surface-initiated ring opening polymer..
The behaviour of honeycomb film formation from star polymers with various fluorine content
Zhou Zhang, Timothy C Hughes, Paul A Gurr, Anton Blencowe, Hemayet Uddin, Xiaojuan Hao, Greg G Qiao
A series of poly((1H,1H-pentafluoropropyl acrylate)-ran-(methyl methacrylate)) (poly(PFPA-ran-MMA)) star polymers with varying flu..
Low-Fouling, Biospecific Films Prepared by the Continuous Assembly of Polymers
Stefanie N Guntari, Edgar HH Wong, Tor K Goh, Rona Chandrawati, Anton Blencowe, Frank Caruso, Greg G Qiao
We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a..
Factors influencing the growth and topography of nanoscale films fabricated by ROMP-mediated continuous assembly of polymers
Stefanie N Guntari, Tor K Goh, Anton Blencowe, Edgar HH Wong, Frank Caruso, Greg G Qiao
The continuous assembly of polymers (CAP) mediated via ring-opening metathesis polymerization (ROMP) is demonstrated as a simple a..
Phototriggered, Metal-Free Continuous Assembly of Polymers for the Fabrication of Ultrathin Films
Edgar HH Wong, Stefanie N Guntari, Anton Blencowe, Martin P van Koeverden, Frank Caruso, Greg G Qiao
A facile and metal-free thin film fabrication technology based on the photoinduced continuous assembly of polymers (photoCAP) is d..