Can Persistent Bladder Pain Be Treated By Targeting Trpa1 Expressing Nociceptors?

Grant number: 1003512 | Funding period: 2012 - 2014

Completed

Abstract

Persistent visceral pain is extremely difficult to treat and manage. To solve this problem we need to understand how pain nerves in internal organs differ from those in skin and muscle. We have discovered a pain-detecting molecule TRPA1 in bladder sensory nerves. We aim to show how bladder inflammation changes the function of these bladder pain detectors and test a new way of selectively anesthetising them. We also will use a new technique to study how the bladder lining detects pain.