IMMUNE REGULATION EFFECTOR FUNCTION AND THERAPY

T-NHL subtypes and clinical perspective

H Miles Prince

2021-07-01

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke

2016-11-18

The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive ..

TGF-beta inhibits the activation and functions of NK cells by repressing the mTOR pathway

Sebastien Viel, Antoine Marcais, Fernando Souza-Fonseca Guimaraes, Roisin Loftus, Jessica Rabilloud, Morgan Grau, Sophie Degouve, Sophia Djebali, Amelien Sanlaville, Emily Charrier, Jacques Bienvenu, Julien C Marie, Christophe Caux, Jacqueline Marvel, Liam Town, Nicholas D Huntington, Laurent Bartholin, David Finlay, Mark J Smyth, Thierry Walzer

2016-02-16

Transforming growth factor-β (TGF-β) is a major immunosuppressive cytokine that maintains immune homeostasis and prevents autoimmu..

Antigen Specificity of Type I NKT Cells Is Governed by TCR beta-Chain Diversity

Garth Cameron, Daniel G Pellicci, Adam P Uldrich, Gurdyal S Besra, Petr Illarionov, Spencer J Williams, Nicole L La Gruta, Jamie Rossjohn, Dale I Godfrey

2015-11-15

NKT cells recognize lipid-based Ags presented by CD1d. Type I NKT cells are often referred to as invariant owing to their mostly i..

Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells

Benjamin J Wolf, Raju VV Tatituri, Catarina F Almeida, Jerome Le Nours, Veemal Bhowruth, Darryl Johnson, Adam P Uldrich, Fong-Fu Hsu, Manfred Brigl, Gurdyal S Besra, Jamie Rossjohn, Dale I Godfrey, Michael B Brenner

2015-09-15

Semi-invariant/type I NKT cells are a well-characterized CD1d-restricted T cell subset. The availability of potent Ags and tetrame..

Immunosurveillance and therapy of multiple myeloma are CD226 dependent

Camille Guillerey, Lucas Ferrari de Andrade, Slavica Vuckovic, Kim Miles, Shin Foong Ngiow, Michelle CR Yong, Michele WL Teng, Marco Colonna, David S Ritchie, Martha Chesi, P Leif Bergsagel, Geoffrey R Hil, Mark J Smyth, Ludovic Martinet

2015-05-01

Multiple myeloma (MM) is an age-dependent hematological malignancy. Evaluation of immune interactions that drive MM relies on in v..

MAIT cells are depleted early but retain functional cytokine expression in HIV infection

Caroline S Fernandez, Thakshila Amarasena, Anthony D Kelleher, Jamie Rossjohn, James McCluskey, Dale I Godfrey, Stephen J Kent

2015-02-01

Mucosal-associated invariant T (MAIT) cells home to mucosal sites and exert antimicrobial activity against bacteria and other micr..

Trafficking of T Cells into Tumors

Clare Y Slaney, Michael H Kershaw, Phillip K Darcy

2014-12-15

T cells are a crucial component of the immune response to infection and cancer. In addition to coordinating immunity in lymphoid t..

Foxp3 Expression in Macrophages Associated with RENCA Tumors in Mice

Christel Devaud, Carmen SM Yong, Liza B John, Jennifer A Westwood, Connie PM Duong, Colin M House, Delphine Denoyer, Jason Li, Phillip K Darcy, Michael H Kershaw

2014-09-29

The transcription factor Foxp3 represents the most specific functional marker of CD4+ regulatory T cells (TRegs). However, previou..

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

Christopher J Chan, Ludovic Martinet, Susan Gilfillan, Fernando Souza-Fonseca-Guimaraes, Melvyn T Chow, Liam Town, David S Ritchie, Marco Colonna, Daniel M Andrews, Mark J Smyth

2014-05-01

CD96, CD226 (DNAM-1) and TIGIT belong to an emerging family of receptors that interact with nectin and nectin-like proteins. CD226..

CD1d-lipid antigen recognition by the gamma delta TCR

Adam P Uldrich, Jerome Le Nours, Daniel G Pellicci, Nicholas A Gherardin, Kirsty G McPherson, Ricky T Lim, Onisha Patel, Travis Beddoe, Stephanie Gras, Jamie Rossjohn, Dale I Godfrey

2013-11-01

The T cell repertoire comprises αβ and γδ T cell lineages. Although it is established how αβ T cell antigen receptors (TCRs) inter..

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Rangsima Reantragoon, Alexandra J Corbett, Isaac G Sakala, Nicholas A Gherardin, John B Furness, Zhenjun Chen, Sidonia BG Eckle, Adam P Uldrich, Richard W Birkinshaw, Onisha Patel, Lyudmila Kostenko, Bronwyn Meehan, Katherine Kedzierska, Ligong Liu, David P Fairlie, Ted H Hansen, Dale I Godfrey, Jamie Rossjohn, James McCluskey, Lars Kjer-Nielsen

2013-10-21

Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) α-chain, TRAV1-2-TRAJ33, and are ..

Cloning and characterising an unusual perforin from chicken (Gallus gallus)

Michael E D'Angelo, Arash Arjomand, Joseph A Trapani, Phillip I Bird

2013-10-01

In mammals the 67 kDa pore-forming protein perforin is essential to the granule exocytosis pathway used by cytotoxic lymphocytes t..

DOCK8 is critical for the survival and function of NKT cells

Greg Crawford, Anselm Enders, Uzi Gileadi, Sanda Stankovic, Qian Zhang, Teresa Lambe, Tanya L Crockford, Helen E Lockstone, Alexandra Freeman, Peter D Arkwright, Joanne M Smart, Cindy S Ma, Stuart G Tangye, Christopher C Goodnow, Vincenzo Cerundolo, Dale I Godfrey, Helen C Su, Katrina L Randall, Richard J Cornall

2013-09-19

Patients with the dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome suffer from recurrent viral and bacterial infection..

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

Sherene Loi, Sandra Pommey, Benjamin Haibe-Kains, Paul A Beavis, Phillip K Darcy, Mark J Smyth, John Stagg

2013-07-02

Using gene-expression data from over 6,000 breast cancer patients, we report herein that high CD73 expression is associated with a..

A conserved human T cell population targets mycobacterial antigens presented by CD1b

Ildiko Van Rhijn, Anne Kasmar, Annemieke de Jong, Stephanie Gras, Mugdha Bhati, Marieke E Doorenspleet, Niek de Vries, Dale I Godfrey, John D Altman, Wilco de Jager, Jamie Rossjohn, D Branch Moody

2013-07-01

Human T cell antigen receptors (TCRs) pair in millions of combinations to create complex and unique T cell repertoires for each pe..

BRAF-targeted therapy and immune responses to melanoma

Shin Foong Ngiow, Deborah A Knight, Antoni Ribas, Grant A McArthur, Mark J Smyth

2013-06-01

Type I BRAF inhibitors and immunotherapy constitute two new exciting approaches for the treatment of advanced malignant melanoma. ..

Ex-vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4( ) and CD4(-) subsets

AC Chan, E Leeansyah, A Cochrane, Y d'Udekem d'Acoz, D Mittag, LC Harrison, DI Godfrey, SP Berzins

2013-04-01

Our understanding of human type 1 natural killer T (NKT) cells has been heavily dependent on studies of cells from peripheral bloo..

CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells

Joseph P Sanderson, Patrick J Brennan, Salah Mansour, Gediminas Matulis, Onisha Patel, Nikolai Lissin, Dale I Godfrey, Kazuyoshi Kawahara, Ulrich Zaehringer, Jamie Rossjohn, Michael B Brenner, Stephan D Gadola

2013-03-01

Isoglobotrihexosylceramide (iGb3) has been identified as a potent CD1d-presented self-antigen for mouse invariant natural killer T..

Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs

Raju VV Tatituri, Gerald FM Watts, Veemal Bhowruth, Nathaniel Barton, Alissa Rothchild, Fong-Fu Hsu, Catarina F Almeida, Liam R Cox, Lothar Eggeling, Susanna Cardell, Jamie Rossjohn, Dale I Godfrey, Samuel M Behar, Gurdyal S Besra, Michael B Brenner, Manfred Brigl

2013-01-29

CD1d-restricted natural killer T (NKT) cells include two major subgroups. The most widely studied are Vα14Jα18(+) invariant NKT (i..

Recognition of CD1d-restricted antigens by natural killer T cells

Jamie Rossjohn, Daniel G Pellicci, Onisha Patel, Laurent Gapin, Dale I Godfrey

2012-12-01

Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines following T cell receptor (TCR) a..

ZBTB7B (Th-POK) Regulates the Development of IL-17-Producing CD1d-Restricted Mouse NKT Cells

Anselm Enders, Sanda Stankovic, Charis Teh, Adam P Uldrich, Mehmet Yabas, Torsten Juelich, John A Altin, Sandra Frankenreiter, Hannes Bergmann, Carla M Roots, Konstantinos Kyparissoudis, Chris C Goodnow, Dale I Godfrey

2012-12-01

CD1d-dependent NKT cells represent a heterogeneous family of effector T cells including CD4(+)CD8(-) and CD4(-)CD8(-) subsets that..

MR1 presents microbial vitamin B metabolites to MAIT cells

Lars Kjer-Nielsen, Onisha Patel, Alexandra J Corbett, Jerome Le Nours, Bronwyn Meehan, Ligong Liu, Mugdha Bhati, Zhenjun Chen, Lyudmila Kostenko, Rangsima Reantragoon, Nicholas A Williamson, Anthony W Purcell, Nadine L Dudek, Malcolm J McConville, Richard AJ O'Hair, George N Khairallah, Dale I Godfrey, David P Fairlie, Jamie Rossjohn, James McCluskey

2012-11-29

Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and CD1 family, bind peptide- and lipid-based ..

Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex

Kwok S Wun, Fiona Ross, Onisha Patel, Gurdyal S Besra, Steven A Porcelli, Stewart K Richardson, Santosh Keshipeddy, Amy R Howell, Dale I Godfrey, Jamie Rossjohn

2012-11-09

Human and mouse type I natural killer T (NKT) cells respond to a variety of CD1d-restricted glycolipid antigens (Ags), with their ..

Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

Onisha Patel, Daniel G Pellicci, Stephanie Gras, Maria L Sandoval-Romero, Adam P Uldrich, Thierry Mallevaey, Andrew J Clarke, Jerome Le Nours, Alex Theodossis, Susanna L Cardell, Laurent Gapin, Dale I Godfrey, Jamie Rossjohn

2012-09-01

Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen..

Ex-vivo alpha-Galactosylceramide activation of NKT cells in humans and macaques

Caroline S Fernandez, Garth Cameron, Dale I Godfrey, Stephen J Kent

2012-08-31

NKT cells are key mediators of antiviral and anticancer immunity. Experiments in mice have demonstrated that activation of NKT cel..

CD73-Deficient Mice Are Resistant to Carcinogenesis

John Stagg, Paul A Beavis, Upulie Divisekera, Mira CP Liu, Andreas Moeller, Phillip K Darcy, Mark J Smyth

2012-05-01

CD73 is a cell surface 5'-nucleotidase that converts AMP to adenosine, an immune suppressive molecule. CD73 may promote immune esc..