IMMUNE REGULATION EFFECTOR FUNCTION AND THERAPY

Grant number: 1013667 | Funding period: 2012 - 2016

Completed

Abstract

We seek to understand how white blood cells detect and destroy disease, and how molecules of the immune system punch holes in diseased cells. We wish to learn how cancer can sometimes evade the immune system. Our work will also find out how some common treatments for cancer, like chemotherapy, can be used to boost the immune system and eliminate tumours. Through knowledge gained from these studies, we aim to develop new therapies that can help patients with devastating diseases like cancer.

Related publications (26)

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke

2016-11-18

TGF-beta inhibits the activation and functions of NK cells by repressing the mTOR pathway

Sebastien Viel, Antoine Marcais, Fernando Souza-Fonseca Guimaraes, Roisin Loftus, Jessica Rabilloud, Morgan Grau, Sophie Degouve, Sophia Djebali, Amelien Sanlaville, Emily Charrier, Jacques Bienvenu, Julien C Marie, Christophe Caux, Jacqueline Marvel, Liam Town, Nicholas D Huntington, Laurent Bartholin, David Finlay, Mark J Smyth, Thierry Walzer

2016-02-16

Antigen Specificity of Type I NKT Cells Is Governed by TCR beta-Chain Diversity

Garth Cameron, Daniel G Pellicci, Adam P Uldrich, Gurdyal S Besra, Petr Illarionov, Spencer J Williams, Nicole L La Gruta, Jamie Rossjohn, Dale I Godfrey

2015-11-15

Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells

Benjamin J Wolf, Raju VV Tatituri, Catarina F Almeida, Jerome Le Nours, Veemal Bhowruth, Darryl Johnson, Adam P Uldrich, Fong-Fu Hsu, Manfred Brigl, Gurdyal S Besra, Jamie Rossjohn, Dale I Godfrey, Michael B Brenner

2015-09-15

Immunosurveillance and therapy of multiple myeloma are CD226 dependent

Camille Guillerey, Lucas Ferrari de Andrade, Slavica Vuckovic, Kim Miles, Shin Foong Ngiow, Michelle CR Yong, Michele WL Teng, Marco Colonna, David S Ritchie, Martha Chesi, P Leif Bergsagel, Geoffrey R Hil, Mark J Smyth, Ludovic Martinet

2015-05-01

MAIT cells are depleted early but retain functional cytokine expression in HIV infection

Caroline S Fernandez, Thakshila Amarasena, Anthony D Kelleher, Jamie Rossjohn, James McCluskey, Dale I Godfrey, Stephen J Kent

2015-02-01

Trafficking of T Cells into Tumors

Clare Y Slaney, Michael H Kershaw, Phillip K Darcy

2014-12-15

Foxp3 Expression in Macrophages Associated with RENCA Tumors in Mice

Christel Devaud, Carmen SM Yong, Liza B John, Jennifer A Westwood, Connie PM Duong, Colin M House, Delphine Denoyer, Jason Li, Phillip K Darcy, Michael H Kershaw

2014-09-29

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

Christopher J Chan, Ludovic Martinet, Susan Gilfillan, Fernando Souza-Fonseca-Guimaraes, Melvyn T Chow, Liam Town, David S Ritchie, Marco Colonna, Daniel M Andrews, Mark J Smyth

2014-05-01

CD1d-lipid antigen recognition by the gamma delta TCR

Adam P Uldrich, Jerome Le Nours, Daniel G Pellicci, Nicholas A Gherardin, Kirsty G McPherson, Ricky T Lim, Onisha Patel, Travis Beddoe, Stephanie Gras, Jamie Rossjohn, Dale I Godfrey

2013-11-01

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Rangsima Reantragoon, Alexandra J Corbett, Isaac G Sakala, Nicholas A Gherardin, John B Furness, Zhenjun Chen, Sidonia BG Eckle, Adam P Uldrich, Richard W Birkinshaw, Onisha Patel, Lyudmila Kostenko, Bronwyn Meehan, Katherine Kedzierska, Ligong Liu, David P Fairlie, Ted H Hansen, Dale I Godfrey, Jamie Rossjohn, James McCluskey, Lars Kjer-Nielsen

2013-10-21

Cloning and characterising an unusual perforin from chicken (Gallus gallus)

Michael E D'Angelo, Arash Arjomand, Joseph A Trapani, Phillip I Bird

2013-10-01

DOCK8 is critical for the survival and function of NKT cells

Greg Crawford, Anselm Enders, Uzi Gileadi, Sanda Stankovic, Qian Zhang, Teresa Lambe, Tanya L Crockford, Helen E Lockstone, Alexandra Freeman, Peter D Arkwright, Joanne M Smart, Cindy S Ma, Stuart G Tangye, Christopher C Goodnow, Vincenzo Cerundolo, Dale I Godfrey, Helen C Su, Katrina L Randall, Richard J Cornall

2013-09-19

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

Sherene Loi, Sandra Pommey, Benjamin Haibe-Kains, Paul A Beavis, Phillip K Darcy, Mark J Smyth, John Stagg

2013-07-02

A conserved human T cell population targets mycobacterial antigens presented by CD1b

Ildiko Van Rhijn, Anne Kasmar, Annemieke de Jong, Stephanie Gras, Mugdha Bhati, Marieke E Doorenspleet, Niek de Vries, Dale I Godfrey, John D Altman, Wilco de Jager, Jamie Rossjohn, D Branch Moody

2013-07-01

BRAF-targeted therapy and immune responses to melanoma

Shin Foong Ngiow, Deborah A Knight, Antoni Ribas, Grant A McArthur, Mark J Smyth

2013-06-01

Ex-vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4( ) and CD4(-) subsets

AC Chan, E Leeansyah, A Cochrane, Y d'Udekem d'Acoz, D Mittag, LC Harrison, DI Godfrey, SP Berzins

2013-04-01

CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells

Joseph P Sanderson, Patrick J Brennan, Salah Mansour, Gediminas Matulis, Onisha Patel, Nikolai Lissin, Dale I Godfrey, Kazuyoshi Kawahara, Ulrich Zaehringer, Jamie Rossjohn, Michael B Brenner, Stephan D Gadola

2013-03-01

Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs

Raju VV Tatituri, Gerald FM Watts, Veemal Bhowruth, Nathaniel Barton, Alissa Rothchild, Fong-Fu Hsu, Catarina F Almeida, Liam R Cox, Lothar Eggeling, Susanna Cardell, Jamie Rossjohn, Dale I Godfrey, Samuel M Behar, Gurdyal S Besra, Michael B Brenner, Manfred Brigl

2013-01-29

Recognition of CD1d-restricted antigens by natural killer T cells

Jamie Rossjohn, Daniel G Pellicci, Onisha Patel, Laurent Gapin, Dale I Godfrey

2012-12-01

ZBTB7B (Th-POK) Regulates the Development of IL-17-Producing CD1d-Restricted Mouse NKT Cells

Anselm Enders, Sanda Stankovic, Charis Teh, Adam P Uldrich, Mehmet Yabas, Torsten Juelich, John A Altin, Sandra Frankenreiter, Hannes Bergmann, Carla M Roots, Konstantinos Kyparissoudis, Chris C Goodnow, Dale I Godfrey

2012-12-01

MR1 presents microbial vitamin B metabolites to MAIT cells

Lars Kjer-Nielsen, Onisha Patel, Alexandra J Corbett, Jerome Le Nours, Bronwyn Meehan, Ligong Liu, Mugdha Bhati, Zhenjun Chen, Lyudmila Kostenko, Rangsima Reantragoon, Nicholas A Williamson, Anthony W Purcell, Nadine L Dudek, Malcolm J McConville, Richard AJ O'Hair, George N Khairallah, Dale I Godfrey, David P Fairlie, Jamie Rossjohn, James McCluskey

2012-11-29

Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex

Kwok S Wun, Fiona Ross, Onisha Patel, Gurdyal S Besra, Steven A Porcelli, Stewart K Richardson, Santosh Keshipeddy, Amy R Howell, Dale I Godfrey, Jamie Rossjohn

2012-11-09

Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

Onisha Patel, Daniel G Pellicci, Stephanie Gras, Maria L Sandoval-Romero, Adam P Uldrich, Thierry Mallevaey, Andrew J Clarke, Jerome Le Nours, Alex Theodossis, Susanna L Cardell, Laurent Gapin, Dale I Godfrey, Jamie Rossjohn

2012-09-01

Ex-vivo alpha-Galactosylceramide activation of NKT cells in humans and macaques

Caroline S Fernandez, Garth Cameron, Dale I Godfrey, Stephen J Kent

2012-08-31

CD73-Deficient Mice Are Resistant to Carcinogenesis

John Stagg, Paul A Beavis, Upulie Divisekera, Mira CP Liu, Andreas Moeller, Phillip K Darcy, Mark J Smyth

2012-05-01

Researchers