UNDERSTANDING A NOVEL MUTATION THAT CAUSES DEAFNESS
Grant number: 1019941 | Funding period: 2012 - 2014
In 2010 a novel genetic mutation was identified that causes progressive hearing loss in humans, however, it was not established why this mutation leads to the disease. We propose that the mutation renders cells of the inner ear more susceptible to death caused by noise trauma. We will investigate this in a mouse model of the human condition. This could lead to the development of therapies that prevent hearing loss.