CLINICAL PREDICTORS OF OUTCOME IN THE ULTRA HIGH RISK FOR PSYCHOSIS ("PRODROMAL") POPULATION

Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis

Subash Raj Susai, Colm Healy, David Mongan, Meike Heurich, Jonah F Byrne, Mary Cannon, Gerard Cagney, Kieran Wynne, Connie Markulev, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft

2022-10-28

Preliminary evidence indicates beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) in early psychosis. The present s..

Effects of omega-3 polyunsaturated fatty acid supplementation on cognitive functioning in youth at ultra-high risk for psychosis: secondary analysis of the NEURAPRO randomised controlled trial

Nicholas Cheng, Alison McLaverty, Barnaby Nelson, Connie Markulev, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B Hicikie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler, Swapna Verma, Rebekah Street, Andrew Thompson, Hok Pan Yuen

2022-09-08

BACKGROUND: Cognitive impairments are well-established features of psychotic disorders and are present when individuals are at ult..

Twelve-Month Cognitive Trajectories in Individuals at Ultra-High Risk for Psychosis: A Latent Class Analysis

K Allott, SJ Schmidt, HP Yuen, SJ Wood, B Nelson, C Markulev, S Lavoie, WJ Brewer, MR Schäfer, N Mossaheb, M Schlögelhofer, S Smesny, IB Hickie, GE Berger, EYH Chen, L De Haan, DH Nieman, M Nordentoft, A Riecher-Rössler, S Verma

2022-01-01

Understanding longitudinal cognitive performance in individuals at ultra-high risk for psychosis (UHR) is important for informing ..

The association of plasma inflammatory markers with omega-3 fatty acids and their mediating role in psychotic symptoms and functioning: An analysis of the NEURAPRO clinical trial

Subash Raj Susai, David Mongan, Colm Healy, Mary Cannon, Barnaby Nelson, Connie Markulev, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schloegelhofer, Stefan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma, Andrew Thompson

2021-10-08

There is increasing evidence that dysregulation of polyunsaturated fatty acids (FAs) mediated membrane function plays a role in th..

Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing

Corrado Sandini, Daniela Zoller, Maude Schneider, Anjali Tarun, Marco Armondo, Barnaby Nelson, Paul G Amminger, Hok Pan Yuen, Connie Markulev, Monica R Schaffer, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler

2021-09-27

Causal interactions between specific psychiatric symptoms could contribute to the heterogenous clinical trajectories observed in e..

Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis An ENIGMA Working Group Mega-analysis

Maria Jalbrzikowski, Rebecca A Hayes, Stephen J Wood, Dorte Nordholm, Juan H Zhou, Paolo Fusar-Poli, Peter J Uhlhaas, Tsutomu Takahashi, Gisela Sugranyes, Yoo Bin Kwak, Daniel H Mathalon, Naoyuki Katagiri, Christine I Hooker, Lukasz Smigielski, Tiziano Colibazzi, Esther Via, Jinsong Tang, Shinsuke Koike, Paul E Rasser, Chantal Michel

2021-05-05

IMPORTANCE: The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at..

Greater preference for eveningness is associated with negative symptoms in an ultra-high risk for psychosis sample

Jashmina J Shetty, Christian Nicholas, Barnaby Nelson, Patrick D McGorry, Suzie Lavoie, Connie Markulev, Miriam R Schafer, Andrew Thompson, Hok Pan Yuen, Alison R Yung, Dorien H Nieman, Lieuwe de Haan, G Paul Amminger, Jessica A Hartmann

2021-02-03

AIM: Investigating biological processes in at-risk individuals may help elucidate the aetiological mechanisms underlying psychosis..

Comparison of erythrocyte omega-3 index, fatty acids and molecular phospholipid species in people at ultra-high risk of developing psychosis and healthy people

Ayedh Alqarni, Todd W Mitchell, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler, Swapna Verma, Andrew Thompson

2020-12-01

People classified as ultra-high risk (UHR) of developing psychosis have reduced cellular membrane omega-3 and omega-6 polyunsatura..

Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis

Ayedh Alqarni, Todd W Mitchell, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schlogelhofer, Stephan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler, Swapna Verma, Andrew Thompson

2020-12-01

Omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) are necessary for optimum mental health, with recent studies showing l..

Cognitive functioning in ultra -high risk for psychosis individuals with and without depression: Secondary analysis of findings from the NEURAPRO randomized clinical trial

Sumudu Rasangi Mallawaarachchi, G Paul Amminger, John Farhall, Luke K Bolt, Barnaby Nelson, Hok Pan Yuen, Patrick D McGorry, Connie Markulev, Miriam R Schaefer, Nilufar Mossaheb, Monika Schloegelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma

2020-04-01

Neurocognitive impairments are well established in both ultra-high risk (UHR) for psychosis and major depressive disorder (MDD). D..

The NEURAPRO Biomarker Analysis: Long-Chain Omega-3 Fatty Acids Improve 6-Month and 12-Month Outcomes in Youths at Ultra-High Risk for Psychosis

G Paul Amminger, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schloegelhofer, Stephan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, Patrick D McGorry

2020-02-01

BACKGROUND: NEURAPRO was a multicenter, placebo-controlled trial of long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs) (fi..

Trajectories of symptom severity and functioning over a three-year period in a psychosis high-risk sample: A secondary analysis of the Neurapro trial

Jessica A Hartmann, Stefanie J Schmidt, Patrick D McGorry, Maximus Berger, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Ian B Hickie, Suzie Lavoie, Connie Markulev, Nilufar Mossaheb, Dorien H Nieman, Merete Nordentoft, Andrea Polari, Anita Riecher-Rossler, Miriam R Schafer, Monika Schlogelhofer, Stefan Smesny, Andrew Thompson, Swapna K Verma

2020-01-01

The Ultra-High Risk (UHR) for psychosis group is known to be heterogeneous with diverse outcomes. This study aimed to: 1. Identify..

Neurocognition as a predictor of transition to psychotic disorder and functional outcomes in ultra-high risk participants: Findings from the NEURAPRO randomized clinical trial

Luke K Bolt, G Paul Amminger, John Farhall, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schafer, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma, Andrew Thompson

2019-04-01

BACKGROUND: Neurocognitive impairments experienced by individuals at ultra-high risk (UHR) for psychosis are potential predictors ..

Perceptual abnormalities in an ultra-high risk for psychosis population relationship to trauma and co-morbid disorder

Karen O' Connor, Barnaby Nelson, Mary Cannon, Alison Yung, Andrew Thompson

2019-04-01

AIMS: The aims of this study were 3-fold. We wished to investigate whether at baseline entry to an ultra-high risk (UHR) clinic wh..

Persistent negative symptoms in individuals at Ultra High Risk for psychosis

Alison R Yung, Barnaby Nelson, Patrick D McGorry, Stephen J Wood, Ashleigh Lin

2019-04-01

Persistent negative symptoms (PNS) defined as negative symptoms that persist for at least six months in the absence of high levels..

Longitudinal determinants of client treatment satisfaction in an intensive first-episode psychosis treatment programme

Lisa N Cruz, Emily Kline, Larry J Seidman, Kyle S Minor, Eric C Meyer, Carina Iati, Suzanna V Zimmet, Michelle Friedman-Yakoobian

2017-08-01

AIM: Previous evidence demonstrates that higher treatment satisfaction is strongly associated with improved clinical outcomes and ..

Negative Psychosis Prevention Trials Reply

Patrick D McGorry, Barnaby Nelson, Paul Amminger

2017-06-01

Using clinical information to make individualized prognostic predictions in people at ultra high risk for psychosis

Andrea Mechelli, Ashleigh Lin, Stephen Wood, Patrick McGorry, Paul Amminger, Stefania Tognin, Philip McGuire, Jonathan Young, Barnaby Nelson, Alison Yung

2017-06-01

Recent studies have reported an association between psychopathology and subsequent clinical and functional outcomes in people at u..

Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis

Renate LEP Reniers, Ashleigh Lin, Alison R Yung, Nikolaos Koutsouleris, Barnaby Nelson, Vanessa L Cropley, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis, Stephen J Wood

2017-03-01

Most individuals at ultra-high risk (UHR) for psychosis do not transition to frank illness. Nevertheless, many have poor clinical ..

Effect of omega-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders The NEURAPRO Randomized Clinical Trial

Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schaefer, Nilufar Mossaheb, Monika Schloegelhofer, Stephan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, G Paul Amminger

2017-01-01

IMPORTANCE: A promising treatment to prevent onset and improve outcomes in patients at ultrahigh risk for psychosis is dietary sup..

Opening the Black Box of Cognitive-Behavioural Case Management in Clients with Ultra-High Risk for Psychosis

Jessica A Hartmann, Patrick D McGorry, Stefanie J Schmidt, G Paul Amminger, Hok Pan Yuen, Connie Markulev, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Ian B Hickie, Suzie Lavoie, Meredith J McHugh, Nilufar Mossaheb, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Miriam R Schafer, Monika Schloegelhofer, Stefan Smesny, Andrew Thompson

2017-01-01

BACKGROUND: Cognitive-behavioural therapy (CBT) is the first-choice treatment in clients with ultra-high risk (UHR) for psychosis...

White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids

Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R Schafer, G Paul Amminger

2016-08-11

BACKGROUND: Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain ..

Further examination of the reducing transition rate in ultra high risk for psychosis samples: The possible role of earlier intervention

B Nelson, HP Yuen, A Lin, SJ Wood, PD McGorry, JA Hartmann, AR Yung

2016-07-01

BACKGROUND: The rate of transition to psychotic disorder in ultra high risk (UHR) patients has declined in recent cohorts. The rea..

Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

Vanessa L Cropley, Ashleigh Lin, Barnaby Nelson, Renate LEP Reniers, Alison R Yung, Cali F Bartholomeusz, Paul Klauser, Dennis Velakoulis, Patrick McGorry, Stephen J Wood, Christos Pantelis

2016-06-01

Declining transition rates to psychotic disorder in "ultra-high risk" clients: Investigation of a dilution effect

Jessica A Hartmann, Hok Pan Yuen, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Stephen J Wood, Suzie Lavoie, Barnaby Nelson

2016-01-01

During recent years, a decrease has been noted in the rate of transition of ultra-high risk (UHR) clients to a psychotic disorder...

Neighbourhood characteristics and the rate of identification of young people at ultra-high risk for psychosis

Brian O'Donoghue, Alison R Yung, Stephen Wood, Andrew Thompson, Ashleigh Lin, Patrick McGorry, Barnaby Nelson

2015-12-01

There is a higher incidence of psychotic disorders in more socially deprived neighbourhoods and a higher risk in migrants living i..

Discrete Alterations of Brain Network Structural Covariance in Individuals at Ultra-High Risk for Psychosis

Kareen Heinze, Renate LEP Reniers, Barnaby Nelson, Alison R Yung, Ashleigh Lin, Ben J Harrison, Christos Pantelis, Dennis Velakoulis, Patrick D McGorry, Stephen J Wood

2015-06-01

BACKGROUND: Investigation of aberrant large-scale brain networks offers novel insight into the role these networks play in diverse..

Social environmental risk factors for transition to psychosis in an Ultra-High Risk population

Brian O'Donoghue, Barnaby Nelson, Hok Pan Yuen, Abbie Lane, Stephen Wood, Andrew Thompson, Ashleigh Lin, Patrick McGorry, Alison R Yung

2015-02-01

Anomalous self-experience and childhood trauma in first-episode schizophrenia

Elisabeth Haug, Merete Oie, Ole A Andreassen, Unni Bratlien, Barnaby Nelson, Monica Aas, Paul Moller, Ingrid Melle

2015-01-01

BACKGROUND: Anomalous self-experiences (ASEs) are viewed as core features of schizophrenia. Childhood trauma (CT) has been postula..

The relationship between personality traits and psychotic like experiences in a large non-clinical adolescent sample

S Wiltink, B Nelson, E Velthorst, JTW Wigman, A Lin, G Baksheev, E Cosgrave, M Ross, J Ryan, AR Yung

2015-01-01

Objective: The relationship between personality and psychosis is well established. It has been suggested that this relationship ma..

Social environmental risk factors for transition to psychosis in an ultra-high risk (UHR) population

Brian O'Donoghue, Barnaby Nelson, Hok Pan Yuen, Abbie Lane, Stephen Wood, Andrew Thompson, Ashleigh Lin, Patrick McGorry, Alison Yung

2014-11-01

OBJECTIVE: Despite social environmental factors such as deprivation, urbanicity, migration and adversity being established risk fa..

Sources of clinical distress in young people at ultra-high risk of psychosis

Marta Rapado-Castro, Patrick D McGorry, Alison Yung, Ana Calvo, Barnaby Nelson

2014-11-01

BACKGROUND: Substantial controversy has been generated since the proposal to include "Attenuated Psychosis Syndrome" in DSM-5, bas..

Sulcogyral pattern and sulcal count of the orbitofrontal cortex in individuals at ultra high risk for psychosis

Suzie Lavoie, Cali F Bartholomeuz, Barnaby Nelson, Ashleigh Lin, Patrick D McGorry, Dennis Velakoulis, Sarah L Whittle, Alison R Yung, Christos Pantelis, Stephen J Wood

2014-04-01

Three types of orbitofrontal cortex (OFC) sulcogyral patterns have been identified in the general population. The distribution of ..

Emotion recognition as a predictor of transition to a psychotic disorder in ultra-high risk participants

Kelly A Allott, Miriam R Schaefer, Andrew Thompson, Barnaby Nelson, Sarah Bendall, Cali F Bartholomeusz, Hok Pan Yuen, Patrick D McGorry, Monika Schloegelhofer, Andreas Bechdolf, G Paul Amminger

2014-03-01

AIMS: Recent research has shown emotion recognition to be impaired in individuals at ultra-high risk (UHR) for developing a psycho..

Attenuated Psychosis Syndrome: Don't Jump the Gun

Barnaby Nelson

2014-01-01

Attenuated psychosis syndrome (APS) was introduced in DSM-5 as a condition for further study. A number of concerns have been raise..

What are the neurocognitive correlates of basic self-disturbance in schizophrenia?: Integrating phenomenology and neurocognition. Part 1 (Source monitoring deficits)

B Nelson, TJ Whitford, S Lavoie, LA Sass

2014-01-01

Phenomenological research indicates that disturbance of the basic sense of self may be a core phenotypic marker of schizophrenia s..

What are the neurocognitive correlates of basic self-disturbance in schizophrenia?: Integrating phenomenology and neurocognition Part 2 (Aberrant salience)

B Nelson, TJ Whitford, S Lavoie, LA Sass

2014-01-01

Phenomenological research indicates that disturbance of the basic sense of self may be a core phenotypic marker of schizophrenia s..

History of trauma and the association with baseline symptoms in an Ultra-High Risk for psychosis cohort

Eva Velthorst, Barnaby Nelson, Karen O'Connor, Nilufar Mossaheb, Lieuwe de Haan, Annie Bruxner, Magenta B Simmons, Alison R Yung, Andrew Thompson

2013-11-30

Few studies have addressed the correlates of trauma in young people at Ultra-High Risk (UHR) of developing a psychotic disorder. W..

Long-term Follow-up of a Group at Ultra High Risk ("Prodromal") for Psychosis The PACE 400 Study

Barnaby Nelson, Hok Pan Yuen, Stephen J Wood, Ashleigh Lin, Daniela Spiliotacopoulos, Annie Bruxner, Christina Broussard, Magenta Simmons, Debra L Foley, Warrick J Brewer, Shona M Francey, G Paul Amminger, Andrew Thompson, Patrick D McGorry, Alison R Yung

2013-08-01

IMPORTANCE: The ultra high-risk (UHR) criteria were introduced to prospectively identify patients at high risk of psychotic disord..

Omega-3 Fatty Acid Supplementation in Adolescents With Borderline Personality Disorder and Ultra-High Risk Criteria for Psychosis: A Post Hoc Subgroup Analysis of a Double-Blind, Randomized Controlled Trial

G Paul Amminger, Andrew M Chanen, Susanne Ohmann, Claudia M Klier, Nilufar Mossaheb, Andreas Bechdolf, Barnaby Nelson, Andrew Thompson, Patrick D McGorry, Alison R Yung, Miriam R Schaefer

2013-07-01

OBJECTIVE: To investigate whether long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs) improve functioning and psychiatric..

Neurocognitive functioning in the prodrome of mania-an exploratory study

Aswin Ratheesh, Ashleigh Lin, Barnaby Nelson, Stephen J Wood, Warrick Brewer, Jennifer Betts, Michael Berk, Patrick McGorry, Alison R Yung, Andreas Bechdolf

2013-05-01

BACKGROUND: Cognitive deficits have been well documented in individuals with bipolar disorder (BD) after the first episode of mani..

Transition to first episode psychosis in ultra high risk populations: Does baseline functioning hold the key?

Eva Velthorst, Barnaby Nelson, Suzanne Wiltink, Lieuwe de Haan, Stephen J Wood, Ashleigh Lin, Alison R Yung

2013-01-01

BACKGROUND: Baseline functioning has been found to be a strong predictor of transition to psychosis in ultra high risk populations..