Identification Of A Discrete Lung Cancer Subtype And Characterisation Of Its Genetic And Clinical Profiles

Grant number: 1038699 | Funding period: 2012 - 2015

Completed

Abstract

I believe I can describe a new subtype of lung cancer, which has never been classified by the World Health Organization. This has been previously mis-classified or simply ignored. My hypothesis is that this is a distinct disease by virtue of patterns of genetic abnormalities as well as features visible under the microscope. I also believe it is one of the most aggressive cancers and needs new treatments.

Related publications (7)

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The Clinical Relevance of Pathologic Subtypes in Metastatic Lung Adenocarcinoma

Timothy D Clay, Hongdo Do, Vijaya Sundararajan, Melissa M Moore, Matthew Conron, Gavin M Wright, Sue-Anne McLachlan, Alexander Dobrovic, Prudence A Russell

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Mapping of actionable mutations to histologic subtype domains in lung adenocarcinoma: implications for precision medicine

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2014-03-22

Precision medicine depends on the accurate identification of actionable mutations in a tumor sample. It is unknown how heterogeneo..

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EGFR gene copy number alterations are not a useful screening tool for predicting EGFR mutation status in lung adenocarcinoma

Prudence A Russell, Yong Yu, Hongdo Do, Timothy D Clay, Melissa M Moore, Gavin M Wright, Matthew Conron, Zoe Wainer, Alexander Dobrovic, Sue-Anne McLachlan

2014-01-01

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The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early stage non-small cell lung cancer

Muhammad Alamgeer, Vinod Ganju, Anette Szczepny, Prudence A Russell, Zdenka Prodanovic, Beena Kumar, Zoe Wainer, Tracey Brown, Michal Schneider-Kolsky, Matthew Conron, Gavin Wright, D Neil Watkins

2013-12-01

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A Genomics-Based Classification of Human Lung Tumors

Danila Seidel, Thomas Zander, Lukas C Heukamp, Martin Peifer, Marc Bos, Lynnette Fernandez-Cuesta, Frauke Leenders, Xin Lu, Sascha Ansen, Masyar Gardizi, Chau Nguyen, Johannes Berg, Prudence Russell, Zoe Wainer, Hans-Ulrich Schildhaus, Toni-Maree Rogers, Benjamin Solomon, William Pao, Scott L Carter, Gad Getz

2013-10-30

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Does Lung Adenocarcinoma Subtype Predict Patient Survival? A Clinicopathologic Study Based on the New International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Lung Adenocarcinoma Classification

Prudence A Russell, Zoe Wainer, Gavin M Wright, Marissa Daniels, Matthew Conron, Richard A Williams

2011-09-01