IDENTIFICATION OF A DISCRETE LUNG CANCER SUBTYPE AND CHARACTERISATION OF ITS GENETIC AND CLINICAL PROFILES
Grant number: 1038699 | Funding period: 2012 - 2015
I believe I can describe a new subtype of lung cancer, which has never been classified by the World Health Organization. This has been previously mis-classified or simply ignored. My hypothesis is that this is a distinct disease by virtue of patterns of genetic abnormalities as well as features visible under the microscope. I also believe it is one of the most aggressive cancers and needs new treatments.
Related publications (8)
Prevalence, morphology, and natural history of FGFR1-amplified lung cancer, including squamous cell carcinoma, detected by FISH and SISH
Prudence A Russell, Yong Yu, Richard J Young, Matthew Conron, Zoe Wainer, Naveed Alam, Benjamin Solomon, Gavin M Wright
The aim of this study was to investigate the prevalence of fibroblast growth factor receptor 1 (FGFR1) amplification by fluorescen..
Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer
Christine M Lovly, Nerina T McDonald, Heidi Chen, Sandra Ortiz-Cuaran, Lukas C Heukamp, Yingjun Yan, Alexandra Florin, Luka Ozretic, Diana Lim, Lu Wang, Zhao Chen, Xi Chen, Pengcheng Lu, Paul K Paik, Ronglai Shen, Hailing Jin, Reinhard Buettner, Sascha Ansen, Sven Perner, Michael Brockmann
Crizotinib, a selective tyrosine kinase inhibitor (TKI), shows marked activity in patients whose lung cancers harbor fusions in th..
The Clinical Relevance of Pathologic Subtypes in Metastatic Lung Adenocarcinoma
Timothy D Clay, Hongdo Do, Vijaya Sundararajan, Melissa M Moore, Matthew Conron, Gavin M Wright, Sue-Anne McLachlan, Alexander Dobrovic, Prudence A Russell
INTRODUCTION: The International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society cl..
Mapping of actionable mutations to histologic subtype domains in lung adenocarcinoma: implications for precision medicine
GM Wright, Hongdo Do, Jonathan Weiss, Naveed Z Alam, Vivek Rathi, Marzena Walkiewicz, Thomas John, Prudence A Russell, Alexander Dobrovic
Precision medicine depends on the accurate identification of actionable mutations in a tumor sample. It is unknown how heterogeneo..
EGFR gene copy number alterations are not a useful screening tool for predicting EGFR mutation status in lung adenocarcinoma
Prudence A Russell, Yong Yu, Hongdo Do, Timothy D Clay, Melissa M Moore, Gavin M Wright, Matthew Conron, Zoe Wainer, Alexander Dobrovic, Sue-Anne McLachlan
We investigated if gene copy number (GCN) alterations of the epidermal growth factor receptor (EGFR), as detected by silver enhanc..
The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early stage non-small cell lung cancer
Muhammad Alamgeer, Vinod Ganju, Anette Szczepny, Prudence A Russell, Zdenka Prodanovic, Beena Kumar, Zoe Wainer, Tracey Brown, Michal Schneider-Kolsky, Matthew Conron, Gavin Wright, D Neil Watkins
BACKGROUND: Expression of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 has been functionally associated with a stem cell phenoty..
A Genomics-Based Classification of Human Lung Tumors
Danila Seidel, Thomas Zander, Lukas C Heukamp, Martin Peifer, Marc Bos, Lynnette Fernandez-Cuesta, Frauke Leenders, Xin Lu, Sascha Ansen, Masyar Gardizi, Chau Nguyen, Johannes Berg, Prudence Russell, Zoe Wainer, Hans-Ulrich Schildhaus, Toni-Maree Rogers, Benjamin Solomon, William Pao, Scott L Carter, Gad Getz
We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically..
Does Lung Adenocarcinoma Subtype Predict Patient Survival? A Clinicopathologic Study Based on the New International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Lung Adenocarcinoma Classification
Prudence A Russell, Zoe Wainer, Gavin M Wright, Marissa Daniels, Matthew Conron, Richard A Williams
INTRODUCTION: Lung adenocarcinoma is a heterogeneous group of tumors with a highly variable prognosis, not well predicted by the c..