Identification Of A Discrete Lung Cancer Subtype And Characterisation Of Its Genetic And Clinical Profiles
Grant number: 1038699 | Funding period: 2012 - 2015
I believe I can describe a new subtype of lung cancer, which has never been classified by the World Health Organization. This has been previously mis-classified or simply ignored. My hypothesis is that this is a distinct disease by virtue of patterns of genetic abnormalities as well as features visible under the microscope. I also believe it is one of the most aggressive cancers and needs new treatments.
Related publications (7)
Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer
Christine M Lovly, Nerina T McDonald, Heidi Chen, Sandra Ortiz-Cuaran, Lukas C Heukamp, Yingjun Yan, Alexandra Florin, Luka Ozretic, Diana Lim, Lu Wang, Zhao Chen, Xi Chen, Pengcheng Lu, Paul K Paik, Ronglai Shen, Hailing Jin, Reinhard Buettner, Sascha Ansen, Sven Perner, Michael Brockmann
Mapping of actionable mutations to histologic subtype domains in lung adenocarcinoma: implications for precision medicine
GM Wright, Hongdo Do, Jonathan Weiss, NZ Alam, Vivek Rathi, Marzena Walkiewicz, PA Russell, A Dobrovic
Precision medicine depends on the accurate identification of actionable mutations in a tumor sample. It is unknown how heterogeneo..
The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early stage non-small cell lung cancer
Muhammad Alamgeer, Vinod Ganju, Anette Szczepny, Prudence A Russell, Zdenka Prodanovic, Beena Kumar, Zoe Wainer, Tracey Brown, Michal Schneider-Kolsky, Matthew Conron, Gavin Wright, D Neil Watkins
A Genomics-Based Classification of Human Lung Tumors
Danila Seidel, Thomas Zander, Lukas C Heukamp, Martin Peifer, Marc Bos, Lynnette Fernandez-Cuesta, Frauke Leenders, Xin Lu, Sascha Ansen, Masyar Gardizi, Chau Nguyen, Johannes Berg, Prudence Russell, Zoe Wainer, Hans-Ulrich Schildhaus, Toni-Maree Rogers, Benjamin Solomon, William Pao, Scott L Carter, Gad Getz
Does Lung Adenocarcinoma Subtype Predict Patient Survival? A Clinicopathologic Study Based on the New International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Lung Adenocarcinoma Classification
Prudence A Russell, Zoe Wainer, Gavin M Wright, Marissa Daniels, Matthew Conron, Richard A Williams