A NEW APPROACH TO TARGETING CELL GROWTH FOR THE TREATMENT OF CANCER

Grant number: 1038852 | Funding period: 2012 - 2014

Completed

Abstract

We have made the fundamental discovery that ribosomal gene transcription is not simply a 'house keeping' process in cancer cells but is required to maintain malignant cell viability. Strikingly inhibition of ribosomal gene transcription using a novel small molecule inhibitor, CX-5461, shows profound selectivity for malignant cells over normal cells. This proposal will translate these observations into 'first in man' phase 1 clinical trials of CX-5461 for the treatment of blood cancers.

Related publications (5)

University of Melbourne Researchers