Gene Therapy For Preventing Progressive Sensorineural Hearing Loss And Restoring Hearing

Grant number: 1024350 | Funding period: 2012 - 2015

Completed

Abstract

This proposal aims to study the clinical feasibility and safety of gene therapy in the guinea pig cochlea for preventing progressive hearing loss and restoring hearing. Two cell survival genes (GDNF and BDNF) will be studied for preserving sensory (hair) cells and hearing nerves, while a gene called Atoh1 will be investigated for its ability to regenerate new hair cells and restore hearing after the onset of progressive hearing loss.

Related publications (3)

Scholarly works icon

Atoh1 gene therapy in the cochlea for hair cell regeneration.

Rachael T Richardson, Patrick J Atkinson

2015-03-01

INTRODUCTION: The sensory epithelium of the cochlea is a complex structure containing hair cells, supporting cells and auditory ne..

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Treating hearing disorders with cell and gene therapy

Lisa N Gillespie, Rachael T Richardson, Bryony A Nayagam, Andrew K Wise

2014-12-01

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Gene Therapy Boosts the Bionic Ear

Robert K Shepherd, Andrew K Wise

2014-04-23

Researchers

Robert Shepherd

Stephen O'Leary

Rachael Richardson