Gene Therapy For Preventing Progressive Sensorineural Hearing Loss And Restoring Hearing

Grant number: 1024350 | Funding period: 2012 - 2015

Completed

Abstract

This proposal aims to study the clinical feasibility and safety of gene therapy in the guinea pig cochlea for preventing progressive hearing loss and restoring hearing. Two cell survival genes (GDNF and BDNF) will be studied for preserving sensory (hair) cells and hearing nerves, while a gene called Atoh1 will be investigated for its ability to regenerate new hair cells and restore hearing after the onset of progressive hearing loss.