GENE THERAPY FOR PREVENTING PROGRESSIVE SENSORINEURAL HEARING LOSS AND RESTORING HEARING
Grant number: 1024350 | Funding period: 2012 - 2015
This proposal aims to study the clinical feasibility and safety of gene therapy in the guinea pig cochlea for preventing progressive hearing loss and restoring hearing. Two cell survival genes (GDNF and BDNF) will be studied for preserving sensory (hair) cells and hearing nerves, while a gene called Atoh1 will be investigated for its ability to regenerate new hair cells and restore hearing after the onset of progressive hearing loss.
Related publications (6)
Hair Cell Regeneration after ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs
Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Rachael T Richardson
The degeneration of hair cells in the mammalian cochlea results in permanent sensorineural hearing loss. This study aimed to promo..