NANOPARTICLE BASED NEUROTROPHIN DELIVERY TO PROMOTE DIRECTED NEURITE GROWTH AND AUDITORY NERVE RESCUE FOLLOWING DEAFNESS
Grant number: 1005071 | Funding period: 2012 - 2013
The cochlear implant provides hearing information to the severe-profoundly deaf by electrically stimulating the auditory nerves of the inner ear. Deafness causes these auditory nerves to gradually degenerate leaving fewer nerves for the cochlear implant to stimulate. We propose to reverse this neural degeneration by delivering therapeutic drugs to the inner ear using tiny nanoparticles. This novel technology is expected to have application in other areas of neural degenerative disease.
Related publications (7)
Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea
Andrew K Wise, Justin Tan, Yajun Wang, Frank Caruso, Robert K Shepherd
Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf ..
Drug delivery: mesoporous silica supraparticles for sustained inner-ear drug delivery (small 21/2014).
Y Wang, AK Wise, J Tan, JW Maina, RK Shepherd, F Caruso
Mesoporous silica supraparticles (MS-SPs) self-assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caru..
Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs
James W Maina, Jiwei Cui, Mattias Bjoernmalm, Andrew K Wise, Robert K Shepherd, Frank Caruso
This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demo..
DEVELOPMENT OF A CELL-BASED TREATMENT FOR LONG-TERM NEUROTROPHIN EXPRESSION AND SPIRAL GANGLION NEURON SURVIVAL
MP Zanin, M Hellstroem, RK Shepherd, AR Harvey, LN Gillespie
Spiral ganglion neurons (SGNs), the target cells of the cochlear implant, undergo gradual degeneration following loss of the senso..
Chronic neurotrophin delivery promotes ectopic neurite growth from the spiral ganglion of deafened cochleae without compromising the spatial selectivity of cochlear implants
TG Landry, JB Fallon, AK Wise, RK Shepherd
Cochlear implants restore hearing cues in the severe-profoundly deaf by electrically stimulating spiral ganglion neurons (SGNs). H..
Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration
Justin Tan, Yajun Wang, Xiaopei Yip, Fergal Glynn, Robert K Shepherd, Frank Caruso
Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica tem..