NANOPARTICLE BASED NEUROTROPHIN DELIVERY TO PROMOTE DIRECTED NEURITE GROWTH AND AUDITORY NERVE RESCUE FOLLOWING DEAFNESS
Grant number: 1005071 | Funding period: 2012 - 2013
The cochlear implant provides hearing information to the severe-profoundly deaf by electrically stimulating the auditory nerves of the inner ear. Deafness causes these auditory nerves to gradually degenerate leaving fewer nerves for the cochlear implant to stimulate. We propose to reverse this neural degeneration by delivering therapeutic drugs to the inner ear using tiny nanoparticles. This novel technology is expected to have application in other areas of neural degenerative disease.
Related publications (7)
Drug delivery: mesoporous silica supraparticles for sustained inner-ear drug delivery (small 21/2014).
Y Wang, AK Wise, J Tan, JW Maina, RK Shepherd, F Caruso
Mesoporous silica supraparticles (MS-SPs) self-assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caru..