Harnessing the 'omics revolution to investigate drug response and resistance mechanisms in Giardia duodenalis
Grant number: LP120200122 | Funding period: 2012 - 2017
This international research project will harness cutting-edge technologies to explore how Giardia, a major global cause of diarrhoeal illness in humans, responds to and becomes resistant to key anti-giardial drugs, providing valuable information for drug preservation and development.
Related publications (7)
Annotation of the Giardia proteome through structure-based homology and machine learning
Brendan RE Ansell, Bernard J Pope, Peter Georgeson, Samantha J Emery-Corbin, Aaron R Jex
Background: Large-scale computational prediction of protein structures represents a cost-effective alternative to empirical struct..
Proteomic diversity in a prevalent human-infective Giardia duodenalis sub-species
Samantha J Emery-Corbin, Daniel Vuong, Ernest Lacey, Staffan G Svard, Brendan RE Ansell, Aaron R Jex
Giardia duodenalis a species complex of gastrointestinal protists, with assemblages A and B infective to humans. To date, post-gen..
Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis
Samantha J Emery, Louise Baker, Brendan RE Ansell, Mehdi Mirzaei, Paul A Haynes, Malcom J McConville, Staffan G Svard, Aaron R Jex
Background: Metronidazole (Mtz) is the frontline drug treatment for multiple anaerobic pathogens, including the gastrointestinal p..
Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines
Brendan RE Ansell, Louise Baker, Samantha J Emery, Malcolm J McConville, Staffan G Svard, Robin B Gasser, Aaron R Jex
Giardia duodenalis is an intestinal parasite that causes 200-300 million episodes of diarrhoea annually. Metronidazole (Mtz) is a ..
Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis
Brendan RE Ansell, Malcolm J McConville, Louise Baker, Pasi K Korhonen, Samantha J Emery, Staffan G Svard, Robin B Gasser, Aaron R Jex
Understanding how parasites respond to stress can help to identify essential biological processes. Giardia duodenalis is a parasit..
Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites
Brendan RE Ansell, Malcolm J McConville, Louise Baker, Pasi K Korhonen, Neil D Young, Ross S Hall, Cristian AA Rojas, Staffan G Svard, Robin B Gasser, Aaron R Jex
Giardia duodenalis is the most common gastrointestinal protozoan parasite of humans and a significant contributor to the global bu..
Drug resistance in Giardia duodenalis
Brendan RE Ansell, Malcolm J McConville, Showgy Y Ma'ayeh, Michael J Dagley, Robin B Gasser, Staffan G Svard, Aaron R Jex
Giardia duodenalis is a microaerophilic parasite of the human gastrointestinal tract and a major contributor to diarrheal and post..