EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION
Grant number: 566529 | Funding period: 2009 - 2013
Mental disorders are a major cause of disability in Australia, especially for young people. We have developed a clinical staging model covering the earliest symptoms through persistent disorder to chronic disability. We are investigating neurobiological, personal and social factors which increase the risk of progression through these stages, and novel treatment strategies which may prevent or delay onset and relapse, reduce the impact of illness, and promote recovery. Major public health benefits and better understanding of the onset and progression of illness will result.
Related publications (139)
Toxoplasma gondii, Herpesviridae and long-term risk of transition to first-episode psychosis in an ultra high-risk sample.
E Burkhardt, M Berger, RH Yolken, A Lin, HP Yuen, SJ Wood, SM Francey, A Thompson, PD McGorry, B Nelson, AR Yung, GP Amminger
BACKGROUND: Ultra high-risk (UHR) criteria were introduced to identify people at imminent risk of developing psychosis. To improve..
Exploring presentation differences in multi-cultural youth seeking assistance for mental health problems.
Stephane Shepherd, Cieran Harries, Benjamin Spivak, Anne-Sophie Pichler, Rosemary Purcell
BACKGROUND: Mental ill-health can impact an individual's capacity to interact with others, make decisions, and cope with social ch..
Greater preference for eveningness is associated with negative symptoms in an ultra-high risk for psychosis sample
Jashmina J Shetty, Christian Nicholas, Barnaby Nelson, Patrick D McGorry, Suzie Lavoie, Connie Markulev, Miriam R Schafer, Andrew Thompson, Hok Pan Yuen, Alison R Yung, Dorien H Nieman, Lieuwe de Haan, G Paul Amminger, Jessica A Hartmann
AIM: Investigating biological processes in at-risk individuals may help elucidate the aetiological mechanisms underlying psychosis..
Comparison of erythrocyte omega-3 index, fatty acids and molecular phospholipid species in people at ultra-high risk of developing psychosis and healthy people
Ayedh Alqarni, Todd W Mitchell, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler, Swapna Verma, Andrew Thompson
People classified as ultra-high risk (UHR) of developing psychosis have reduced cellular membrane omega-3 and omega-6 polyunsatura..
Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis
Ayedh Alqarni, Todd W Mitchell, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schlogelhofer, Stephan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler, Swapna Verma, Andrew Thompson
Omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) are necessary for optimum mental health, with recent studies showing l..
What works for mental health problems in youth? Survey of real-world experiences of treatments and side effects
Amy J Morgan, Anna M Ross, Marie BH Yap, Nicola J Reavley, Alexandra Parker, Magenta B Simmons, Faye Scanlan, Anthony F Jorm
AIM: Despite youth being the most common age group for onset of mental disorders, there is less knowledge on the benefits and harm..
Does cortical brain morphology act as a mediator between childhood trauma and transition to psychosis in young individuals at ultra-high risk?
Marta Rapado-Castro, Sarah Whittle, Christos Pantelis, Andrew Thompson, Barnaby Nelson, Eleni P Ganella, Ashleigh Lin, Renate LEP Reniers, Patrick D McGorry, Alison R Yung, Stephen J Wood, Cali F Bartholomeusz
BACKGROUND: Childhood trauma, particularly sexual abuse, has been associated with transition to psychosis in individuals at "ultra..
Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis
Alison McLaverty, Kelly A Allott, Maximus Berger, Rob Hester, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schaefer, Nilufar Mossaheb, Monika Schloegelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma
BACKGROUND: Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for..
Prediction of clinical outcomes beyond psychosis in theultra-highrisk for psychosis population
Andrea Polari, Hok Pan Yuen, Paul Amminger, Gregor Berger, Eric Chen, Lieuwe deHaan, Jessica Hartmann, Connie Markulev, Patrick McGorry, Dorien Nieman, Merete Nordentoft, Anita Riecher-Roessler, Stefan Smesny, John Stratford, Swapna Verma, Alison Yung, Suzie Lavoie, Barnaby Nelson
AIM: Several prediction models have been introduced to identify young people at greatest risk of transitioning to psychosis. To da..
Do schizotypal or borderline personality disorders predict onset of psychotic disorder or persistent attenuated psychotic symptoms in patients at high clinical risk?
H Hadar, H Zhang, LJ Phillips, GP Amminger, GE Berger, EYH Chen, L de Haan, JA Hartmann, IB Hickie, S Lavoie, C Markulev, PD McGorry, N Mossaheb, DH Nieman, M Nordentoft, A Riecher-Rossler, MR Schafer, M Schloegelhofer, S Smesny, A Thompson
Has improved treatment contributed to the declining rate of transition to psychosis in ultra-high-risk cohorts?
MJC Formica, LJ Phillips, JA Hartmann, AR Yung, SJ Wood, A Lin, GP Amminger, PD McGorry, B Nelson
BACKGROUND: The factors contributing to declining psychotic disorder transition rates in ultra-high-risk populations remain unclea..
Cognitive functioning in ultra -high risk for psychosis individuals with and without depression: Secondary analysis of findings from the NEURAPRO randomized clinical trial
Sumudu Rasangi Mallawaarachchi, G Paul Amminger, John Farhall, Luke K Bolt, Barnaby Nelson, Hok Pan Yuen, Patrick D McGorry, Connie Markulev, Miriam R Schaefer, Nilufar Mossaheb, Monika Schloegelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma
Neurocognitive impairments are well established in both ultra-high risk (UHR) for psychosis and major depressive disorder (MDD). D..
Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes
S Youn, LJ Phillips, GP Amminger, G Berger, EYH Chen, L de Haan, JA Hartmann, IB Hickie, S Lavoie, C Markulev, PD McGorry, N Mossaheb, DH Nieman, M Nordentoft, A Riecher-Rossler, MR Schafer, M Schloegelhofer, S Smesny, A Thompson, S Verma
There has been limited research into the predictive value of basic symptoms and their relationship with other psychopathology in p..
The NEURAPRO Biomarker Analysis: Long-Chain Omega-3 Fatty Acids Improve 6-Month and 12-Month Outcomes in Youths at Ultra-High Risk for Psychosis
G Paul Amminger, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schloegelhofer, Stephan Smesny, Ian B Hickie, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, Patrick D McGorry
BACKGROUND: NEURAPRO was a multicenter, placebo-controlled trial of long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs) (fi..
The prognostic significance of attenuated psychotic symptoms in help-seeking youth
H Hazan, T Spelman, GP Amminger, I Hickie, PD McGorry, LJ Phillips, R Purcell, SJ Wood, AR Yung, B Nelson
BACKGROUND: Recent findings suggest that attenuated psychotic symptoms (APS) might serve as a risk factor for general mental healt..
Trajectories of symptom severity and functioning over a three-year period in a psychosis high-risk sample: A secondary analysis of the Neurapro trial
Jessica A Hartmann, Stefanie J Schmidt, Patrick D McGorry, Maximus Berger, Gregor E Berger, Eric YH Chen, Lieuwe de Haan, Ian B Hickie, Suzie Lavoie, Connie Markulev, Nilufar Mossaheb, Dorien H Nieman, Merete Nordentoft, Andrea Polari, Anita Riecher-Rossler, Miriam R Schafer, Monika Schlogelhofer, Stefan Smesny, Andrew Thompson, Swapna K Verma
The Ultra-High Risk (UHR) for psychosis group is known to be heterogeneous with diverse outcomes. This study aimed to: 1. Identify..
Can youth at high risk of illness progression be identified by measures of rumination and sleep-wake disturbance
Ashlee B Grierson, Jan Scott, Nick Glozier, Ian B Hickie, Paul G Amminger, Eoin Killackey, Patrick D McGorry, Christos Pantelis, Lisa Phillips, Elizabeth Scott, Alison R Yung, Rosemary Purcell
AIM: Clinical staging models offer a useful framework for understanding illness trajectories, where individuals are located on a c..
Longitudinal Cognitive Performance in Individuals at Ultrahigh Risk for Psychosis: A 10-year Follow-up
Kelly Allott, Stephen J Wood, Hok Pan Yuen, Alison R Yung, Barnaby Nelson, Warrick J Brewer, Daniela Spiliotacopoulos, Annie Bruxner, Magenta Simmons, Christina Broussard, Sumudu Mallawaarachchi, Christos Pantelis, Patrick D McGorry, Ashleigh Lin
It remains unclear whether the onset of psychosis is associated with deterioration in cognitive performance. The aim of this study..
Neurocognition as a predictor of transition to psychotic disorder and functional outcomes in ultra-high risk participants: Findings from the NEURAPRO randomized clinical trial
Luke K Bolt, G Paul Amminger, John Farhall, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schafer, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma, Andrew Thompson
BACKGROUND: Neurocognitive impairments experienced by individuals at ultra-high risk (UHR) for psychosis are potential predictors ..
The relationship between childhood trauma and clinical characteristics in ultra-high risk for psychosis youth
Chloe de Vos, Andrew Thompson, Paul Amminger, Sarah Bendall, Lieuwe de Haan, Jessica Hartmann, Suzie Lavoie, Connie Markulev, Patrick McGorry, Dorien Nieman, Lisa Phillips, Ulrich Reininghaus, Hok Pan Yuen, Alison Yung, Barnaby Nelson
Mounting evidence suggests that a history of childhood trauma (CT) is associated with an increased risk of developing a psychotic ..
Clinical trajectories in the ultra-high risk for psychosis population
Andrea Polari, Suzie Lavoie, Hok-Pan Yuen, Paul Amminger, Gregor Berger, Eric Chen, Lieuwe deHaan, Jessica Hartmann, Connie Markulev, Fritha Melville, Dorien Nieman, Merete Nordentoft, Anita Riecher-Rossler, Stefan Smesny, John Stratford, Swapna Verma, Alison Yung, Patrick McGorry, Barnaby Nelson
BACKGROUND: Traditionally, research in the ultra-high risk (UHR) for psychosis population has focused on the treatment of existing..
The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo
MJ McHugh, PD McGorry, HP Yuen, IB Hickie, A Thompson, L de Haan, N Mossaheb, S Smesny, A Lin, C Markulev, M Schloegelhofer, SJ Wood, D Nieman, JA Hartmann, M Nordentoft, M Schafer, GP Amminger, A Yung, B Nelson
Individuals are considered Ultra-High-Risk (UHR) for psychosis if they meet a set of standardised criteria including presumed gene..
Changes in triglyceride levels in ultra-high risk for psychosis individuals treated with omega-3 fatty acids
Nilufar Mossaheb, Konstantinos Papageorgiou, Miriam R Schaefer, Jana Becker, Monika Schloegelhofer, G Paul Amminger
AIM: The aim of this analysis was to assess changes in lipid parameters, specifically in triglyceride (TG) levels, in a population..
Attentional set-shifting and social abilities in children with schizotypal and comorbid autism spectrum disorders
Ahmad Abu-Akel, Renee R Testa, Harvey P Jones, Nola Ross, Efstratios Skafidas, Bruce Tonge, Christos Pantelis
OBJECTIVE: While diagnostically independent, autism and schizotypal disorders can co-occur. Their concurrent impact on outcomes an..
Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study
CMJ Wannan, CF Bartholomeusz, VL Cropley, TE Van Rheenen, A Panayiotou, WJ Brewer, TM Proffitt, L Henry, MG Harris, D Velakoulis, P McGorry, C Pantelis, SJ Wood
BACKGROUND: Cognitive deficits are a core feature of schizophrenia, and impairments in most domains are thought to be stable over ..
Impaired mismatch negativity to frequency deviants in individuals at ultra-high risk for psychosis, and preliminary evidence for further
Suzie Lavoie, Bradley N Jack, Oren Griffiths, Ayaka Ando, Paul Amminger, Anthony Couroupis, Aidan Jago, Connie Markulev, Patrick D McGorry, Barnaby Nelson, Andrea Polari, Hok Pan Yuen, Thomas J Whitford
BACKGROUND: There is evidence to suggest that people with established psychotic disorders show impairments in the mismatch negativ..
Effects of omega-3 PUFA on immune markers in adolescent individuals at ultra-high risk for psychosis - Results of the randomized controlled Vienna omega-3 study
Stefan Smesny, Berko Milleit, Miriam R Schaefer, Jana Hesse, Monika Schloegelhofer, Kerstin Langbein, Uta-Christina Hipler, Maximus Berger, David R Cotter, Heinrich Sauer, Patrick D McGorry, G Paul Amminger
Alterations of immune function have been reported in ultra-high risk (UHR) for psychosis patients causing expectations in terms of..
Long-term employment among people at ultra-high risk for psychosis
Jack Cotter, Ashleigh Lin, Richard J Drake, Andrew Thompson, Barnaby Nelson, Patrick McGorry, Stephen J Wood, Alison R Yung
BACKGROUND: Psychotic disorders are associated with high rates of sustained unemployment, however, little is known about the long-..
Using clinical information to make individualized prognostic predictions in people at ultra high risk for psychosis
Andrea Mechelli, Ashleigh Lin, Stephen Wood, Patrick McGorry, Paul Amminger, Stefania Tognin, Philip McGuire, Jonathan Young, Barnaby Nelson, Alison Yung
Recent studies have reported an association between psychopathology and subsequent clinical and functional outcomes in people at u..
Cannabis-induced attenuated psychotic symptoms: implications for prognosis in young people at ultra-high risk for psychosis
MJ McHugh, PD McGorry, AR Yung, A Lin, SJ Wood, JA Hartmann, B Nelson
BACKGROUND: Cannabis use shows a robust dose-dependent relationship with psychosis risk among the general population. Despite this..
Lithium suppression of tau induces brain iron accumulation and neurodegeneration
P Lei, S Ayton, AT Appukuttan, S Moon, JA Duce, I Volitakis, R Cherny, SJ Wood, M Greenough, G Berger, C Pantelis, P McGorry, A Yung, DI Finkelstein, AI Bush
Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, including a Parkinson-like hand ..
Substance use in youth at risk for psychosis
R Carney, AR Yung, GP Amminger, T Bradshaw, N Glozier, DF Hermens, IB Hickie, E Killackey, P McGorry, C Pantelis, SJ Wood, R Purcell
BACKGROUND: People with schizophrenia have high rates of substance use which contributes to co-morbidity and premature mortality. ..
Multi-center MRI prediction models: Predicting sex and illness course in first episode psychosis patients
Mireille Nieuwenhuis, Hugo G Schnack, Neeltje E van Haren, Julia Lappin, Craig Morgan, Antje A Reinders, Diana Gutierrez-Tordesillas, Roberto Roiz-Santianez, Maristela S Schaufelberger, Pedro G Rosa, Marcus V Zanetti, Geraldo F Busatto, Benedicto Crespo-Facorro, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis, Stephen J Wood, Rene S Kahn, Janaina Mourao-Miranda, Paola Dazzan
Structural Magnetic Resonance Imaging (MRI) studies have attempted to use brain measures obtained at the first-episode of psychosi..
Effect of omega-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders The NEURAPRO Randomized Clinical Trial
Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schaefer, Nilufar Mossaheb, Monika Schloegelhofer, Stephan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, G Paul Amminger
Importance: A promising treatment to prevent onset and improve outcomes in patients at ultrahigh risk for psychosis is dietary sup..
A prospective cohort study of depression course, functional disability, and NEET status in help-seeking young adults
Bridianne O'Dea, Rico SC Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykeltun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier
PURPOSE: To examine the associations between depression course, functional disability, and Not in Education or Training (NEET) sta..
White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids
Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R Schafer, G Paul Amminger
BACKGROUND: Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain ..
Further examination of the reducing transition rate in ultra high risk for psychosis samples: The possible role of earlier intervention
B Nelson, HP Yuen, A Lin, SJ Wood, PD McGorry, JA Hartmann, AR Yung
BACKGROUND: The rate of transition to psychotic disorder in ultra high risk (UHR) patients has declined in recent cohorts. The rea..
Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up
Vanessa L Cropley, Ashleigh Lin, Barnaby Nelson, Renate LEP Reniers, Alison R Yung, Cali F Bartholomeusz, Paul Klauser, Dennis Velakoulis, Patrick McGorry, Stephen J Wood, Christos Pantelis
The effectiveness of simple psychological and physical activity interventions for high prevalence mental health problems in young people: A factorial randomised controlled trial
Alexandra G Parker, Sarah E Hetrick, Anthony F Jorm, Andrew J Mackinnon, Patrick D McGorry, Alison R Yung, Faye Scanlan, Jessica Stephens, Shelley Baird, Bridget Moller, Rosemary Purcell
BACKGROUND: The prevalence and burden of disease of depression and anxiety disorders in young people necessitates effective early ..
Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis
Gregor E Berger, Stefan Smesny, Miriam R Schaefer, Berko Milleit, Kerstin Langbein, Uta-Christina Hipler, Christine Milleit, Claudia M Klier, Monika Schloegelhofer, Magdalena Holub, Ingrid Holzer, Michael Berk, Patrick D McGorry, Heinrich Sauer, G Paul Amminger
BACKGROUND: Most studies provide evidence that the skin flush response to nicotinic acid (niacin) stimulation is impaired in schiz..
Cortical Representations of Cognitive Control and Working Memory Are Dependent Yet Non-Interacting
Ian H Harding, Ben J Harrison, Michael Breakspear, Christos Pantelis, Murat Yuecel
Cognitive control (CC) and working memory (WM) are concurrently necessary for adaptive human behavior. These processes are thought..
Declining transition rates to psychotic disorder in "ultra-high risk" clients: Investigation of a dilution effect
Jessica A Hartmann, Hok Pan Yuen, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Stephen J Wood, Suzie Lavoie, Barnaby Nelson
During recent years, a decrease has been noted in the rate of transition of ultra-high risk (UHR) clients to a psychotic disorder...
Childhood maltreatment and transition to psychotic disorder independently predict long-term functioning in young people at ultra-high risk for psychosis
AR Yung, J Cotter, SJ Wood, P McGorry, AD Thompson, B Nelson, A Lin
BACKGROUND: Individuals identified as at ultra-high risk (UHR) for psychosis are at risk of poor functional outcome regardless of ..
Demographic and clinical characteristics of young people seeking help at youth mental health services: baseline findings of the Transitions Study
Rosemary Purcell, Anthony F Jorm, Ian B Hickie, Alison R Yung, Christos Pantelis, G Paul Amminger, Nick Glozier, Eoin Killackey, Lisa J Phillips, Stephen J Wood, Susy Harrigan, Andrew Mackinnon, Elizabeth Scott, Daniel F Hermens, Adam J Guastella, Amanda Kenyon, Laura Mundy, Alissa Nichles, Antoinette Scaffidi, Daniela Spiliotacopoulos
AIM: The Transitions Study was designed to establish a cohort of young people (12-25 years) seeking help for mental health problem..
Neighbourhood characteristics and the rate of identification of young people at ultra-high risk for psychosis
Brian O'Donoghue, Alison R Yung, Stephen Wood, Andrew Thompson, Ashleigh Lin, Patrick McGorry, Barnaby Nelson
There is a higher incidence of psychotic disorders in more socially deprived neighbourhoods and a higher risk in migrants living i..
Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia
Cali F Bartholomeusz, Eleni P Ganella, Izelle Labuschagne, Chad Bousman, Christos Pantelis
Impairments in social cognition and poor social functioning are core features of schizophrenia-spectrum disorders. In recent years..
Effects of omega-3 PUFA on the vitamin E and glutathione antioxidant defense system in individuals at ultra-high risk of psychosis
Stefan Smesny, Berko Milleit, Miriam R Schaefer, Uta-Christina Hipler, Christine Milleit, Cornelia Wiegand, Jana Hesse, Claudia M Klier, Magdalena Holub, Ingrid Holzer, Michael Berk, Patrick D McGorry, Heinrich Sauer, G Paul Amminger
BACKGROUND: Oxidative stress and impaired antioxidant defenses are reported in schizophrenia and are associated with disturbed neu..
Cognitive intervention in early psychosis - preserving abilities versus remediating deficits
Christos Pantelis, Cassandra Wannan, Cali F Bartholomeusz, Kelly Allott, Patrick D McGorry
Remediation strategies have focused on a deficits model to plan restorative interventions, with inconsistent results. Here, we pro..
Declining transition rates to psychosis: the contribution of potential changes in referral pathways to an ultra-high-risk service
Suzanne Wiltink, Eva Velthorst, Barnaby Nelson, Patrick M McGorry, Alison R Yung
AIM: On the basis of applying 'ultra-high-risk' (UHR) criteria, initially high rates of transition to psychosis were reported. How..
Discrete Alterations of Brain Network Structural Covariance in Individuals at Ultra-High Risk for Psychosis
Kareen Heinze, Renate LEP Reniers, Barnaby Nelson, Alison R Yung, Ashleigh Lin, Ben J Harrison, Christos Pantelis, Dennis Velakoulis, Patrick D McGorry, Stephen J Wood
BACKGROUND: Investigation of aberrant large-scale brain networks offers novel insight into the role these networks play in diverse..
Outcomes of Nontransitioned Cases in a Sample at Ultra-High Risk for Psychosis
Ashleigh Lin, Stephen J Wood, Barnaby Nelson, Amanda Beavan, Patrick McGorry, Alison R Yung
OBJECTIVE: Two-thirds of individuals identified as at ultra-high risk for psychosis do not develop psychotic disorder over the med..
The relationship between stress, HPA axis functioning and brain structure in first episode psychosis over the first 12 weeks of treatment
Renate LEP Reniers, Belinda Garner, Christina Phassouliotis, Lisa J Phillips, Connie Markulev, Christos Pantelis, Sarah Bendall, Patrick D McGorry, Stephen J Wood
Stress and abnormal hypothalamic-pituitary-adrenal axis functioning have been implicated in the early phase of psychosis and may p..
Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis
BRE Ansell, DB Dwyer, SJ Wood, E Bora, WJ Brewer, TM Proffitt, D Velakoulis, PD McGorry, C Pantelis
BACKGROUND: Whether there are differential effects of first-generation antipsychotics (FGAs) and second-generation antipsychotics ..
Effective connectivity within the frontoparietal control network differentiates cognitive control and working memory
Ian H Harding, Murat Yuecel, Ben J Harrison, Christos Pantelis, Michael Breakspear
Cognitive control and working memory rely upon a common fronto-parietal network that includes the inferior frontal junction (IFJ),..
Emotion recognition in unaffected first-degree relatives of individuals with first-episode schizophrenia
Kelly A Allott, Simon Rice, Cali F Bartholomeusz, Claudia Klier, Monika Schloegelhofer, Miriam R Schaefer, G Paul Amminger
OBJECTIVE: Impairments in recognising negative emotions are found in individuals with first-episode and chronic schizophrenia and ..
Olfactory identification deficits at identification as ultra-high risk for psychosis are associated with poor functional outcome
A Lin, WJ Brewer, AR Yung, B Nelson, C Pantelis, SJ Wood
BACKGROUND: We have previously reported that olfactory identification (OI) deficits are a promising premorbid marker of transition..
Transitions Study of predictors of illness progression in young people with mental ill health: study methodology
R Purcell, AF Jorm, IB Hickie, AR Yung, C Pantelis, GP Amminger, N Glozier, E Killackey, L Phillips, SJ Wood, A Mackinnon, E Scott, A Kenyon, L Mundy, A Nichles, A Scaffidi, D Spiliotacopoulos, L Taylor, JPY Tong, S Wiltink
AIM: An estimated 75% of mental disorders begin before the age of 24 and approximately 25% of 13-24-year-olds are affected by ment..
The Melbourne Assessment of Schizotypy in Kids: A Useful Measure of Childhood Schizotypal Personality Disorder
Harvey P Jones, Renee R Testa, Nola Ross, Marc L Seal, Christos Pantelis, Bruce Tonge
Despite being identified as a high risk cohort for psychosis, there has been relatively little research on the clinical presentati..
The relationship between personality traits and psychotic like experiences in a large non-clinical adolescent sample
S Wiltink, B Nelson, E Velthorst, JTW Wigman, A Lin, G Baksheev, E Cosgrave, M Ross, J Ryan, AR Yung
Objective: The relationship between personality and psychosis is well established. It has been suggested that this relationship ma..
Relationship between amygdala volume and emotion recognition in adolescents at ultra-high risk for psychosis
Cali F Bartholomeusz, Sarah L Whittle, Eleanor Pilioussis, Kelly Allott, Simon Rice, Miriam R Schaefer, Christos Pantelis, G Paul Amminger
Amygdala volume has been proposed as a neural risk biomarker for psychotic illness, but findings in the ultra-high risk for psycho..
Social environmental risk factors for transition to psychosis in an ultra-high risk (UHR) population
Brian O'Donoghue, Barnaby Nelson, Hok Pan Yuen, Abbie Lane, Stephen Wood, Andrew Thompson, Ashleigh Lin, Patrick McGorry, Alison Yung
OBJECTIVE: Despite social environmental factors such as deprivation, urbanicity, migration and adversity being established risk fa..
Impact of comorbid anxiety disorders and obsessive-compulsive disorder on 24-month clinical outcomes of bipolar I disorder
Sung-Wan Kim, Lesley Berk, Jayashri Kulkarni, Seetal Dodd, Anthony de Castella, Paul B Fitzgerald, G Paul Amminger, Michael Berk
BACKGROUND: This study investigated the impact of comorbid obsessive-compulsive disorder (OCD) and four anxiety disorders [panic d..
Relationship between membrane fatty acids and cognitive symptoms and information processing in individuals at ultra-high risk for psychosis
Sung-Wan Kim, Miriam R Schaefer, Claudia M Klier, Michael Berk, Simon Rice, Kelly Allott, Cali F Bartholomeusz, Sarah L Whittle, Eleanor Pilioussis, Christos Pantelis, Patrick D McGorry, G Paul Amminger
Cognitive symptoms and impairment are central to schizophrenia and often an early sign of this condition. The present study invest..
Altered Striatal Functional Connectivity in Subjects With an At-Risk Mental State for Psychosis
Orwa Dandash, Alex Fornito, Jimmy Lee, Richard SE Keefe, Michael WL Chee, R Alison Adcock, Christos Pantelis, Stephen J Wood, Ben J Harrison
Recent functional imaging work in individuals experiencing an at-risk mental state (ARMS) for psychosis has implicated dorsal stri..
Cognitive deficits in youth with familial and clinical high risk to psychosis: a systematic review and meta-analysis
E Bora, A Lin, SJ Wood, AR Yung, PD McGorry, C Pantelis
OBJECTIVE: It is likely that cognitive deficits are vulnerability markers for developing schizophrenia, as these deficits are alre..
Beliefs about mental disorder treatment and prognosis: Comparison of health professionals with the Australian public
Amy J Morgan, Nicola J Reavley, Anthony F Jorm
OBJECTIVE: In the 1990s, large differences in beliefs about the helpfulness of treatments for mental disorders were observed betwe..
Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis
Qing Zhao, Zhi Li, Jia Huang, Chao Yan, Paola Dazzan, Christos Pantelis, Eric FC Cheung, Simon SY Lui, Raymond CK Chan
BACKGROUND: Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been convent..
Sexual Trauma Increases the Risk of Developing Psychosis in an Ultra High-Risk "Prodromal" Population
Andrew D Thompson, Barnaby Nelson, Hok Pan Yuen, Ashleigh Lin, Guenter Paul Amminger, Patrick D McGorry, Stephen J Wood, Alison R Yung
Studies indicate a high prevalence of childhood trauma in patient cohorts with established psychotic disorder and in those at risk..
Sulcogyral pattern and sulcal count of the orbitofrontal cortex in individuals at ultra high risk for psychosis
Suzie Lavoie, Cali F Bartholomeuz, Barnaby Nelson, Ashleigh Lin, Patrick D McGorry, Dennis Velakoulis, Sarah L Whittle, Alison R Yung, Christos Pantelis, Stephen J Wood
Three types of orbitofrontal cortex (OFC) sulcogyral patterns have been identified in the general population. The distribution of ..
Altered depth of the olfactory sulcus in ultra high-risk individuals and patients with psychotic disorders
Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Barnaby Nelson, Ashleigh Lin, Murat Yuecel, Lisa J Phillips, Yumiko Nakamura, Michio Suzuki, Warrick J Brewer, Tina M Proffitt, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis
A shallow olfactory sulcus has been reported in schizophrenia, possibly reflecting abnormal forebrain development during early ges..
Emotion recognition as a predictor of transition to a psychotic disorder in ultra-high risk participants
Kelly A Allott, Miriam R Schaefer, Andrew Thompson, Barnaby Nelson, Sarah Bendall, Cali F Bartholomeusz, Hok Pan Yuen, Patrick D McGorry, Monika Schloegelhofer, Andreas Bechdolf, G Paul Amminger
AIMS: Recent research has shown emotion recognition to be impaired in individuals at ultra-high risk (UHR) for developing a psycho..
Omega-3 fatty acid supplementation changes intracellular phospholipase A 2 activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis
S Smesny, B Milleit, UC Hipler, C Milleit, MR Schäfer, CM Klier, M Holub, I Holzer, GE Berger, M Otto, I Nenadic, M Berk, PD Mcgorry, H Sauer, GP Amminger
The identification of an ultra-high risk (UHR) profile for psychosis and a greater understanding of its prodrome have led to incre..
Omega-3 fatty acid supplementation changes intracellular phospholipase A(2) activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis
S Smesny, B Milleit, U-C Hipler, C Milleit, MR Schaefer, CM Klier, M Holub, I Holzer, GE Berger, M Otto, I Nenadic, M Berk, PD McGorry, H Sauer, GP Amminger
The identification of an ultra-high risk (UHR) profile for psychosis and a greater understanding of its prodrome have led to incre..
Delayed sleep onset in depressed young people
Nicholas Glozier, Bridianne O'Dea, Patrick D McGorry, Christos Pantelis, Gunter Paul Amminger, Daniel F Hermens, Rosemary Purcell, Elizabeth Scott, Ian B Hickie
BACKGROUND: The circadian abnormality of delayed sleep phase has been suggested to characterise a subgroup of depressed young adul..
Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis
S Tognin, A Riecher-Roessler, EM Meisenzahl, SJ Wood, C Hutton, SJ Borgwardt, N Koutsouleris, AR Yung, P Allen, LJ Phillips, PD McGorry, I Valli, D Velakoulis, B Nelson, J Woolley, C Pantelis, P McGuire, A Mechelli
BACKGROUND: Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have..
A cross-sectional exploration of the clinical characteristics of disengaged (NEET) young people in primary mental healthcare
Bridianne O'Dea, Nicholas Glozier, Rosemary Purcell, Patrick D McGorry, Jan Scott, Kristy-Lee Feilds, Daniel F Hermens, John Buchanan, Elizabeth M Scott, Alison R Yung, Eoin Killacky, Adam J Guastella, Ian B Hickie
OBJECTIVE: Youth with mental health problems often have difficulties engaging in education and employment. In Australia, youth men..
Disruption of structure-function coupling in the schizophrenia connectome
Luca Cocchi, Ian H Harding, Anton Lord, Christos Pantelis, Murat Yucel, Andrew Zalesky
Neuroimaging studies have demonstrated that the phenomenology of schizophrenia maps onto diffuse alterations in large-scale functi..
Neurocognitive predictors of transition to psychosis: medium- to long-term findings from a sample at ultra-high risk for psychosis
A Lin, AR Yung, B Nelson, WJ Brewer, R Riley, M Simmons, C Pantelis, SJ Wood
BACKGROUND: Individuals at ultra-high risk (UHR) for psychosis show reduced neurocognitive performance across domains but it is un..
Beliefs of Australian health professionals about the helpfulness of interventions for mental disorders: Differences between professions and change over time
Amy J Morgan, Anthony F Jorm, Nicola J Reavley
OBJECTIVE: To assess the beliefs of general practitioners (GPs), psychiatrists and clinical psychologists about the helpfulness of..
Markers of brain illness may be hidden in your olfactory ability: A Japanese perspective
Yuri Masaoka, Christos Pantelis, Anthony Phillips, Mitsuru Kawamura, Masaru Mimura, Genshin Minegishi, Ikuo Homma
There is evidence that impaired human cognitive abilities are reflected by loss of olfactory abilities. Declining olfactory percep..
Effect of omega-3 fatty acids for indicated prevention of young patients at risk for psychosis: When do they begin to be effective?
Nilufar Mossaheb, Miriam R Schaefer, Monika Schloegelhofer, Claudia M Klier, Susan M Cotton, Patrick D McGorry, G Paul Amminger
The results of a recent double-blind, randomized, placebo-controlled trial performed in 81 young patients at ultra-high risk for p..
Long-term Follow-up of a Group at Ultra High Risk ("Prodromal") for Psychosis The PACE 400 Study
Barnaby Nelson, Hok Pan Yuen, Stephen J Wood, Ashleigh Lin, Daniela Spiliotacopoulos, Annie Bruxner, Christina Broussard, Magenta Simmons, Debra L Foley, Warrick J Brewer, Shona M Francey, G Paul Amminger, Andrew Thompson, Patrick D McGorry, Alison R Yung
IMPORTANCE: The ultra high-risk (UHR) criteria were introduced to prospectively identify patients at high risk of psychotic disord..
Omega-3 Fatty Acid Supplementation in Adolescents With Borderline Personality Disorder and Ultra-High Risk Criteria for Psychosis: A Post Hoc Subgroup Analysis of a Double-Blind, Randomized Controlled Trial
G Paul Amminger, Andrew M Chanen, Susanne Ohmann, Claudia M Klier, Nilufar Mossaheb, Andreas Bechdolf, Barnaby Nelson, Andrew Thompson, Patrick D McGorry, Alison R Yung, Miriam R Schaefer
OBJECTIVE: To investigate whether long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs) improve functioning and psychiatric..
Sulcogyral patterns and morphological abnormalities of the orbitofrontal cortex in psychosis
Cali F Bartholomeusz, Sarah L Whittle, Alice Montague, Brendan Ansell, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis, Stephen J Wood
Three types of OFC sulcogyral patterns have been identified in the general population. The distribution of these three types has b..
Clinical classification in mental health at the cross-roads: which direction next?
Ian B Hickie, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier, Patrick D McGorry
BACKGROUND: After 30 years of consensus-derived diagnostic categories in mental health, it is time to head in new directions. Thos..
Externalized attributional bias in the Ultra High Risk (UHR) for psychosis population
Andrew Thompson, Alicia Papas, Cali Bartholomeusz, Barnaby Nelson, Alison Yung
Specific externalizing attributional biases appear to be common in early psychosis. They may represent trait risk factors for the ..
Theory of mind impairments in first-episode psychosis, individuals at ultra-high risk for psychosis and in first-degree relatives of schizophrenia: Systematic review and meta-analysis
Emre Bora, Christos Pantelis
Theory of mind (ToM) deficit is a well-established feature of schizophrenia and has been suggested as a vulnerability marker of th..
Applying clinical staging to young people who present for mental health care
Ian B Hickie, Elizabeth M Scott, Daniel F Hermens, Sharon L Naismith, Adam J Guastella, Manreena Kaur, Anna Sidis, Bradley Whitwell, Nicholas Glozier, Tracey Davenport, Christos Pantelis, Stephen J Wood, Patrick D McGorry
AIM: The study aims to apply clinical staging to young people who present for mental health care; to describe the demographic feat..
Alteration to hippocampal shape in cannabis users with and without schizophrenia
Nadia Solowij, Mark Walterfang, Dan I Lubman, Sarah Whittle, Valentina Lorenzetti, Martin Styner, Dennis Velakoulis, Christos Pantelis, Murat Yuecel
Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users...
A magnetic resonance imaging study of hippocampal, amygdala and subgenual prefrontal cortex volumes in major depression subtypes: Melancholic versus psychotic depression
Konstantina Vassilopoulou, Matilda Papathanasiou, Ioannis Michopoulos, Fotini Boufidou, Panagiotis Oulis, Nikolaos Kelekis, Emmanouil Rizos, Chrysoula Nikolaou, Christos Pantelis, Dennis Velakoulis, Lefteris Lykouras
BACKGROUND: Volumetric studies examining brain structure in depression subtypes are limited and inconclusive. The aim of the curre..
Dynamic Association Between Interpersonal Functioning and Positive Symptom Dimensions of Psychosis Over Time: A Longitudinal Study of Healthy Adolescents
Dina Collip, Johanna TW Wigman, Ashleigh Lin, Barnaby Nelson, Margreet Oorschot, Wilma AM Vollebergh, Jaymee Ryan, Gennedy Baksheev, Marieke Wichers, Jim van Os, Inez Myin-Germeys, Alison R Yung
BACKGROUND: Cross-sectional studies have indicated that alterations in social functioning, particularly interpersonal functioning,..
Transition to first episode psychosis in ultra high risk populations: Does baseline functioning hold the key?
Eva Velthorst, Barnaby Nelson, Suzanne Wiltink, Lieuwe de Haan, Stephen J Wood, Ashleigh Lin, Alison R Yung
BACKGROUND: Baseline functioning has been found to be a strong predictor of transition to psychosis in ultra high risk populations..
Facial and vocal affect perception in people at ultra-high risk of psychosis, first-episode schizophrenia and healthy controls
G Paul Amminger, Miriam R Schaefer, Claudia M Klier, Monika Schloegelhofer, Nilufar Mossaheb, Andrew Thompson, Andreas Bechdolf, Kelly Allott, Patrick D McGorry, Barnaby Nelson
AIM: The study aims to investigate affect recognition in young people at different stages of psychotic illness. METHODS: Seventy-n..
Volumetric Abnormalities Predating the Onset of Schizophrenia and Affective Psychoses: An MRI Study in Subjects at Ultrahigh Risk of Psychosis
Paola Dazzan, Bridget Soulsby, Andrea Mechelli, Stephen J Wood, Dennis Velakoulis, Lisa J Phillips, Alison R Yung, Xavier Chitnis, Ashleigh Lin, Robin M Murray, Patrick D McGorry, Philip K McGuire, Christos Pantelis
It remains unclear whether brain structural abnormalities observed before the onset of psychosis are specific to schizophrenia or ..
Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia: Testing the evidence for an endophenotypic marker
Warrick J Brewer, Ashleigh Lin, Paul J Moberg, Gregory Smutzer, Barnaby Nelson, Alison R Yung, Christos Pantelis, Patrick D McGorry, Bruce I Turetsky, Stephen J Wood
Reports suggesting that schizophrenia participants are more likely to be phenylthiocarbamide (PTC) non-tasters when compared to co..
Borderline personality features and development of psychosis in an 'Ultra High Risk' (UHR) population: a case control study
Andrew Thompson, Barnaby Nelson, Andreas Bechdolf, Andrew M Chanen, Isabel Domingues, Emma McDougall, Alison R Yung
AIMS: There is clinical uncertainty as to whether borderline personality disorder (BPD) traits in those with an 'at risk mental st..
Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder
Leonardo F Fontenelle, Ben J Harrison, Jesus Pujol, Christopher G Davey, Alex Fornito, Emre Bora, Christos Pantelis, Murat Yuecel
BACKGROUND: Obsessive-compulsive disorder (OCD) is associated with a range of emotional abnormalities linked to its defining sympt..
Frontal delta power associated with negative symptoms in ultra-high risk individuals who transitioned to psychosis
Suzie Lavoie, Miriam R Schaefer, Thomas J Whitford, Franz Benninger, Martha Feucht, Claudia M Klier, Hok Pan Yuen, Christos Pantelis, Patrick D McGorry, G Paul Amminger
It has recently been shown that treatment with long-chain omega-3 polyunsaturated fatty acids (PUFAs) could decrease the rate of t..
Functional Connectivity in Brain Networks Underlying Cognitive Control in Chronic Cannabis Users
Ian H Harding, Nadia Solowij, Ben J Harrison, Michael Takag, Valentina Lorenzetti, Dan I Lubman, Marc L Seal, Christos Pantelis, Murat Yuecel
The long-term effect of regular cannabis use on brain function underlying cognitive control remains equivocal. Cognitive control a..
Gray matter abnormalities in Major Depressive Disorder: A meta-analysis of voxel based morphometry studies
Emre Bora, Alex Fornito, Christos Pantelis, Murat Yuecel
BACKGROUND: Voxel-based morphometry (VBM) has been widely used to quantify structural brain changes associated with Major Depressi..
Size and shape of the caudate nucleus in individuals with bipolar affective disorder
Daniel Ong, Mark Walterfang, Gin S Malhi, Martin Styner, Dennis Velakoulis, Christos Pantelis
OBJECTIVE: The caudate nucleus (CN) is a crucial component of the ventral striatum, which is part of a prefrontal-striatal-thalami..
The Impact of Cannabis Use on Cognitive Functioning in Patients With Schizophrenia: A Meta-analysis of Existing Findings and New Data in a First-Episode Sample
Murat Yuecel, Emre Bora, Dan I Lubman, Nadia Solowij, Warrick J Brewer, Sue M Cotton, Philippe Conus, Michael J Takagi, Alex Fornito, Stephen J Wood, Patrick D McGorry, Christos Pantelis
Cannabis use is highly prevalent among people with schizophrenia, and coupled with impaired cognition, is thought to heighten the ..
The effects of gender on grey matter abnormalities in major psychoses: a comparative voxelwise meta-analysis of schizophrenia and bipolar disorder
E Bora, A Fornito, M Yuecel, C Pantelis
BACKGROUND: Recent evidence from genetic and familial studies revitalized the debate concerning the validity of the distinction be..
The relationship between coping and subclinical psychotic experiences in adolescents from the general population - a longitudinal study
A Lin, JTW Wigman, B Nelson, WAM Vollebergh, J van Os, G Baksheev, J Ryan, QAW Raaijmakers, A Thompson, AR Yung
BACKGROUND: Subclinical psychotic experiences during adolescence may represent liability for developing psychotic disorder. Both c..
Neuroimaging and Treatment Evidence for Clinical Staging in Psychotic Disorders: From the At-Risk Mental State to Chronic Schizophrenia
Stephen J Wood, Alison R Yung, Patrick D McGorry, Christos Pantelis
A new approach to understanding severe mental disorders such as schizophrenia is to adopt a clinical staging model. Such a model d..
Atypical antipsychotics cause an acute increase in cutaneous hand blood flow in patients with schizophrenia and schizoaffective disorder
Esther Blessing, Linda Kader, Reza Arpandy, Youichirou Ootsuka, William W Blessing, Christos Pantelis
OBJECTIVE: Clinical studies suggest resting thermoregulatory cutaneous vasomotor tone could be increased in schizophrenia, resulti..
Understanding aberrant white matter development in schizophrenia: an avenue for therapy?
Mark Walterfang, Dennis Velakoulis, Thomas J Whitford, Christos Pantelis
Although historically gray matter changes have been the focus of neuropathological and neuroradiological studies in schizophrenia,..
Using internet enabled mobile devices and social networking technologies to promote exercise as an intervention for young first episode psychosis patients
Eoin Killackey, Anna Lee Anda, Martin Gibbs, Mario Alvarez-Jimenez, Andrew Thompson, Pamela Sun, Gennady N Baksheev
BACKGROUND: Young people with first episode psychosis are at an increased risk for a range of poor health outcomes. In contrast to..
Neuroanatomical abnormalities in schizophrenia: A multimodal voxelwise meta-analysis and meta-regression analysis
Emre Bora, Alex Fornito, Joaquim Radua, Mark Walterfang, Marc Seal, Stephen J Wood, Murat Yuecel, Dennis Velakoulis, Christos Pantelis
Despite an increasing number of published voxel based morphometry studies of schizophrenia, there has been no adequate attempt to ..
The effectiveness of simple psychological and exercise interventions for high prevalence mental health problems in young people: a factorial randomised controlled trial
Alexandra G Parker, Sarah E Hetrick, Anthony F Jorm, Alison R Yung, Patrick D McGorry, Andrew Mackinnon, Bridget Moller, Rosemary Purcell
BACKGROUND: The prevalence of mental illness in young people is the highest of any age group, with the onset of depression, anxiet..
Relational memory in first episode psychosis: implications for progressive hippocampal dysfunction after illness onset
Cali F Bartholomeusz, Tina M Proffitt, Greg Savage, Leonie Simpson, Connie Markulev, Melissa Kerr, Mirabel McConchie, Patrick D McGorry, Christos Pantelis, Gregor E Berger, Stephen J Wood
OBJECTIVE: Verbal episodic memory deficits are prominent in schizophrenia and have also been found in first episode psychosis (FEP..
Hippocampal pathology in individuals at ultra-high risk for psychosis: A multi-modal magnetic resonance study
Stephen J Wood, Damien Kennedy, Lisa J Phillips, Marc L Seal, Murat Yuecel, Barnaby Nelson, Alison R Yung, Graeme Jackson, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis
Although the hippocampus is a key brain region in the pathophysiology of schizophrenia, it is unclear whether structural or bioche..
Caudate nucleus volume in individuals at ultra-high risk of psychosis: A cross-sectional magnetic resonance imaging study
Katrina L Hannan, Stephen J Wood, Alison R Yung, Dennis Velakoulis, Lisa J Phillips, Bridget Soulsby, Gregor Berger, Patrick D McGorry, Christos Pantelis
The aim of the present study was to investigate whether volumetric abnormalities of the caudate nuclei predate the onset of psycho..
Study protocol: The development of a pilot study employing a randomised controlled design to investigate the feasibility and effects of a peer support program following discharge from a specialist first-episode psychosis treatment centre
Jo Robinson, Annie Bruxner, Susy Harrigan, Sarah Bendall, Eoin Killackey, Vittoria Tonin, Katherine Monson, Melissa Thurley, Shona Francey, Alison R Yung
BACKGROUND: Young people with first-episode psychosis (FEP) are at risk of a range of negative outcomes. Specialist FEP services h..
Whole-brain anatomical networks: Does the choice of nodes matter?
Andrew Zalesky, Alex Fornito, Ian H Harding, Luca Cocchi, Murat Yuecel, Christos Pantelis, Edward T Bullmore
Whole-brain anatomical connectivity in living humans can be modeled as a network with diffusion-MRI and tractography. Network node..
OLFACTORY SENSITIVITY: FUNCTIONING IN SCHIZOPHRENIA AND IMPLICATIONS FOR UNDERSTANDING THE NATURE AND PROGRESSION OF PSYCHOSIS
Warrick J Brewer, Christos Pantelis
Prefrontal neural processes maturing during neurodevelopment parallel normal improvement in higher order olfactory processing (ide..
The effect of atypical antipsychotics on pituitary gland volume in patients with first-episode psychosis: A longitudinal MRI study
John-Paul Nicolo, Gregor E Berger, Belinda A Garner, Dennis Velakoulis, Connie Markulev, Melissa Kerr, Patrick D McGorry, Tina-Marie Proffitt, Mirabel McConchie, Christos Pantelis, Stephen J Wood
Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia
Luca Cocchi, Mark Walterfang, Renee Testa, Stephen J Wood, Marc L Seal, John Suckling, Tsutomu Takahashi, Tina-Marie Proffitt, Warrick J Brewer, Christopher Adamson, Bridget Soulsby, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis
Spatial working memory (SWM) dysfunction has been suggested as a trait marker of schizophrenia and implicates a diffuse network in..