ENGINEERING MATERIALS FOR ADVANCES IN NANOMEDICINE

Surface Modification of Spider Silk Particles to Direct Biomolecular Corona Formation.

Alessia CG Weiss, Heike M Herold, Sarah Lentz, Matthew Faria, Quinn A Besford, Ching-Seng Ang, Frank Caruso, Thomas Scheibel

2020-05-20

In recent years, spider silk-based materials have attracted attention because of their biocompatibility, processability, and biode..

Ricocheting Droplets Moving on Super-Repellent Surfaces

Shuaijun Pan, Rui Guo, Joseph J Richardson, Joseph D Berry, Quinn A Besford, Mattias Bjornmalm, Gyeongwon Yun, Ruoxi Wu, Zhixing Lin, Qi-Zhi Zhong, Jiajing Zhou, Qiang Sun, Jianhua Li, Yanbing Lu, Zhichao Dong, Margaret Katherine Banks, Weijian Xu, Jianhui Jiang, Lei Jiang, Frank Caruso

2019-09-12

Droplet bouncing on repellent solid surfaces (e.g., the lotus leaf effect) is a common phenomenon that has aroused interest in var..

Coatings super-repellent to ultralow surface tension liquids

Shuaijun Pan, Rui Guo, Mattias Bjornmalm, Joseph J Richardson, Ling Li, Chang Peng, Nadja Bertleff-Zieschang, Weijian Xu, Jianhui Jiang, Frank Caruso

2018-11-01

High-performance coatings that durably and fully repel liquids are of interest for fundamental research and practical applications..

Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids

Marcin Wojnilowicz, Quinn A Besford, Yun-Long Wu, Xian Jun Loh, Julia A Braunger, Agata Glab, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri

2018-09-01

The poor penetration of nanocarrier-siRNA constructs into tumor tissue is a major hurdle for the in vivo efficacy of siRNA therape..

Minimum information reporting in bio-nano experimental literature

Matthew Faria, Mattias Bjornmalm, Kristofer J Thurecht, Stephen J Kent, Robert G Parton, Maria Kavallaris, Angus PR Johnston, J Justin Gooding, Simon R Corrie, Ben J Boyd, Pall Thordarson, Andrew K Whittaker, Molly M Stevens, Clive A Prestidge, Christopher JH Porter, Wolfgang J Parak, Thomas P Davis, Edmund J Crampin, Frank Caruso

2018-09-01

Studying the interactions between nanoengineered materials and biological systems plays a vital role in the development of biologi..

Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging

Thomas Bonnard, Anand Jayapadman, Jasmine A Putri, Jiwei Cui, Yi Ju, Catherine Carmichael, Thomas A Angelovich, Stephen H Cody, Shauna French, Karline Pascaud, Hannah A Pearce, Shweta Jagdale, Frank Caruso, Christoph E Hagemeyer

2018-07-01

Nanomedicine holds great promise for vascular disease diagnosis and specific therapy, yet rapid sequestration by the mononuclear p..

Microfluidic Examination of the "Hard" Biomolecular Corona Formed on Engineered Particles in Different Biological Milieu

Alessia CG Weiss, Kristian Kempe, Stephan Foerster, Frank Caruso

2018-07-01

The formation of a biomolecular corona around engineered particles determines, in large part, their biological behavior in vitro a..

Supramolecular Metal-Phenolic Gels for the Crystallization of Active Pharmaceutical Ingredients

Md Arifur Rahim, Yuuki Hata, Mattias Bjornmalm, Yi Ju, Frank Caruso

2018-06-27

The use of supramolecular gel media for the crystallization of active pharmaceutical ingredients (APIs) is of interest for control..

Multiligand Metal-Phenolic Assembly from Green Tea Infusions

Md Arifur Rahim, Mattias Bjornmalm, Nadja Bertleff-Zieschang, Yi Ju, Srinivas Mettu, Michael G Leeming, Frank Caruso

2018-03-07

The synthesis of hybrid functional materials using the coordination-driven assembly of metal-phenolic networks (MPNs) is of intere..

Synthesis of Metal Nanoparticles in Metal-Phenolic Networks: Catalytic and Antimicrobial Applications of Coated Textiles

Gyeongwon Yun, Shuaijun Pan, Ting-Yi Wang, Junling Guo, Joseph J Richardson, Frank Caruso

2018-03-07

The synthesis of metal nanoparticle (NP)-coated textiles (nanotextiles) is achieved by a dipping process in water without toxic ch..

Electrochemical Behavior and Redox-Dependent Disassembly of Gallic Acid/Fe-III Metal-Phenolic Networks

Pavel V Cherepanov, Md Arifur Rahim, Nadja Bertleff-Zieschang, Md Abu Sayeed, Anthony P O'Mullane, Simon E Moulton, Frank Caruso

2018-02-14

Metal-phenolic networks (MPNs) are a versatile class of organic-inorganic hybrid systems that are generating interest for applicat..

Probing Transcription Factor Binding Activity and Downstream Gene Silencing in Living Cells with a DNA Nanoswitch

A Bertucci, J Guo, N Oppmann, A Glab, F Ricci, F Caruso, F Cavalieri

2018-01-28

Transcription factor DNA binding activity is of pivotal importance in living systems because of its primary involvement in the reg..

Particle Targeting in Complex Biological Media

Qiong Dai, Nadja Bertleff-Zieschang, Julia A Braunger, Mattias Bjornmalm, Christina Cortez-Jugo, Frank Caruso

2018-01-10

Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, incl..

A Decade of the Protein Corona

Pu Chun Ke, Sijie Lin, Wolfgang J Parak, Thomas P Davis, Frank Caruso

2017-12-01

In this Perspective, we reflect on a decade of research on the protein corona and contemplate its broad implications for future sc..

Influence of Ionic Strength on the Deposition of Metal-Phenolic Networks

Junling Guo, Joseph J Richardson, Quinn A Besford, Andrew J Christofferson, Yunlu Dai, Chien W Ong, Blaise L Tardy, Kang Liang, Gwan H Choi, Jiwei Cui, Pil J Yoo, Irene Yarovsky, Frank Caruso

2017-10-10

Metal-phenolic networks (MPNs) are a versatile class of self-assembled materials that are able to form functional thin films on va..

Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution

Danzi Song, Jiwei Cui, Huanli Sun, Tri-Hung Nguyen, Sheilajen Alcantara, Robert De Rose, Stephen J Kent, Christopher JH Porter, Frank Caruso

2017-10-04

Surface modification is frequently used to tailor the interactions of nanoparticles with biological systems. In many cases, the ch..

Bridging Bio-Nano Science and Cancer Nanomedicine

Mattias Bjornmalm, Kristofer J Thurecht, Michael Michael, Andrew M Scott, Frank Caruso

2017-10-01

The interface of bio-nano science and cancer medicine is an area experiencing much progress but also beset with controversy. Core ..

Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Yunlu Dai, Junling Guo, Ting-Yi Wang, Yi Ju, Andrew J Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J Richardson, Christoph E Hagemeyer, Karen Alt, Frank Caruso

2017-08-23

Therapeutic nanoparticles hold clinical promise for cancer treatment by avoiding limitations of conventional pharmaceuticals. Here..

Role of the Protein Corona Derived from Human Plasma in Cellular Interactions between Nanoporous Human Serum Albumin Particles and Endothelial Cells

Mikhail V Zyuzin, Yan Yan, Raimo Hartmann, Katelyn T Gause, Moritz Nazarenus, Jiwei Cui, Frank Caruso, Wolfgang J Parak

2017-08-01

The presence of a protein corona on various synthetic nanomaterials has been shown to strongly influence how they interact with ce..

An Enzyme-Coated Metal-Organic Framework Shell for Synthetically Adaptive Cell Survival

Kang Liang, Joseph J Richardson, Christian J Doonan, Xavier Mulet, Yi Ju, Jiwei Cui, Frank Caruso, Paolo Falcaro

2017-07-10

A bioactive synthetic porous shell was engineered to enable cells to survive in an oligotrophic environment. Eukaryotic cells (yea..

Formation of Polyrotaxane Particles via Template Assembly

Blaise L Tardy, Shereen Tan, Henk H Dam, Tomoya Suma, Junling Guo, Greg G Qiao, Frank Caruso

2017-07-01

In this study, we report a versatile method to assemble tunable poly(ethylene glycol) (PEG)-based polyrotaxane (PRX) particles and..

Tuning the Properties of Polymer Capsules for Cellular Interactions

Huanli Sun, Jiwei Cui, Yi Ju, Xi Chen, Edgar HH Wong, Jenny Tran, Greg G Qiao, Frank Caruso

2017-07-01

Particle-cell interactions are governed by, among other factors, the composition and surface properties of the particles. Herein, ..

A Partially Graphitic Mesoporous Carbon Membrane with Three Dimensionally Networked Nanotunnels for Ultrasensitive Electrochemical Detection

Cong Fu, Deliang Yi, Chao Deng, Xingdong Wang, Weijia Zhang, Yi Tang, Frank Caruso, Yajun Wang

2017-06-27

A hierarchically porous partially graphitic carbon (HPGC) membrane with three-dimensionally networked nanotunnels is prepared and ..

Rust-Mediated Continuous Assembly of Metal-Phenolic Networks

Md Arifur Rahim, Mattias Bjoernmalm, Nadja Bertleff-Zieschang, Quinn Besford, Srinivas Mettu, Tomoya Suma, Matthew Faria, Frank Caruso

2017-06-13

The use of natural compounds for preparing hybrid molecular films-such as surface coatings made from metal-phenolic networks (MPNs..

Lactosylated Glycogen Nanoparticles for Targeting Prostate Cancer Cells

Quinn A Besford, Marcin Wojnilowicz, Tomoya Suma, Nadja Bertleff-Zieschang, Frank Caruso, Francesca Cayalieri

2017-05-24

Glyconanoparticles that exhibit multivalent binding to lectins are desirable for molecular recognition and therapeutic application..

Modulated Fragmentation of Proapoptotic Peptide Nanoparticles Regulates Cytotoxicity

Tomoya Suma, Jiwei Cui, Markus Muellner, Shiwei Fu, Jenny Tran, Ka Fung Noi, Yi Ju, Frank Caruso

2017-03-22

Peptides perform a diverse range of physiologically important functions. The formulation of nanoparticles directly from functional..

Engineered Hydrogen-Bonded Glycopolymer Capsules and Their Interactions with Antigen Presenting Cells

Kristian Kempe, Sue D Xiang, Paul Wilson, Md Arifur Rahim, Yi Ju, Michael R Whittaker, David M Haddleton, Magdalena Plebanski, Frank Caruso, Thomas P Davis

2017-02-22

Hollow glycopolymer microcapsules were fabricated by hydrogen-bonded layer-by-layer (LbL) assembly, and their interactions with a ..

Cell-Conditioned Protein Coronas on Engineered Particles Influence Immune Responses

Qiong Dai, Junling Guo, Yan Yan, Ching-Seng Ang, Nadja Bertleff-Zieschang, Frank Caruso

2017-02-01

A protein corona, which forms on engineered particles as soon as they are introduced into biological environments, is known to pro..

Interactions between circulating nanoengineered polymer particles and extracellular matrix components in vitro

Julia A Braunger, Mattias Bjornmalm, Nathan A Isles, Jiwei Cui, Timothy MA Henderson, Andrea J O'Connor, Frank Caruso

2017-02-01

The extracellular matrix (ECM) that surrounds cells in vivo represents a biological barrier for nanomaterials in biomedicine. Here..

Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

Hirotaka Ejima, Joseph J Richardson, Frank Caruso

2017-02-01

Surface modification is crucial for conferring novel functionalities to objects and interfaces. However, simple yet versatile stra..

Biofunctional metal-phenolic films from dietary flavonoids

Nadja Bertleff-Zieschang, Md Arifur Rahim, Yi Ju, Julia A Braunger, Tomoya Suma, Yunlu Dai, Shuaijun Pan, Francesca Cavalieri, Frank Caruso

2017-01-18

We assembled dietary, bioactive flavonoids into a metal coordinated network to form thin, surface-bound films and hollow capsules,..

Nanoengineering Particles through Template Assembly

Mattias Bjoernmalm, Jiwei Cui, Nadja Berdeff-Zieschang, Danzi Song, Matthew Faria, Md Arifur Rahim, Frank Caruso

2017-01-10

The nanoengineering of particles is of interest for both fundamental and applied science. How particles are made substantially aff..

Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery

Katelyn T Gause, Adam K Wheatley, Jiwei Cui, Yan Yan, Stephen J Kent, Frank Caruso

2017-01-01

Despite the immense public health successes of immunization over the past century, effective vaccines are still lacking for global..

Patterned Poly(dopamine) Films for Enhanced Cell Adhesion

Xi Chen, Christina Cortez-Jugo, Gwan H Choi, Mattias Bjornmalm, Yunlu Dai, Pil J Yoo, Frank Caruso

2017-01-01

Engineered materials that promote cell adhesion and cell growth are important in tissue engineering and regenerative medicine. In ..

Innovation in Layer-by-Layer Assembly

Joseph J Richardson, Jiwei Cui, Mattias Bjornmalm, Julia A Braunger, Hirotaka Ejima, Frank Caruso

2016-12-14

Methods for depositing thin films are important in generating functional materials for diverse applications in a wide variety of f..

Advancing Research Using Action Cameras

Mattias Bjornmalm, Matthew Faria, Frank Caruso

2016-12-13

Modular assembly of superstructures from polyphenol-functionalized building blocks

Junling Guo, Blaise L Tardy, Andrew J Christofferson, Yunlu Dai, Joseph J Richardson, Wei Zhu, Ming Hu, Yi Ju, Jiwei Cui, Raymond R Dagastine, Irene Yarovsky, Frank Caruso

2016-12-01

The organized assembly of particles into superstructures is typically governed by specific molecular interactions or external dire..

A Framework to Account for Sedimentation and Diffusion in Particle-Cell Interactions

Jiwei Cui, Matthew Faria, Mattias Bjornmalm, Yi Ju, Tomoya Suma, Sylvia T Gunawan, Joseph J Richardson, Hamed Heidar, Sara Bals, Edmund J Crampin, Frank Caruso

2016-11-29

In vitro experiments provide a solid basis for understanding the interactions between particles and biological systems. An importa..

Synthesis of Chemically Asymmetric Silica Nanobottles and Their Application for Cargo Loading and as Nanoreactors and Nanomotors

Deliang Yi, Qian Zhang, Yinghua Liu, Jiaying Song, Yi Tang, Frank Caruso, Yajun Wang

2016-11-14

We report the synthesis of chemically asymmetric silica nanobottles (NBs) with a hydrophobic exterior surface (capped with 3-chlor..

Synthesis of Chemically Asymmetric Silica Nanobottles and Their Application for Cargo Loading and as Nanoreactors and Nanomotors

Deliang Yi, Qian Zhang, Yinghua Liu, Jiaying Song, Yi Tang, Frank Caruso, Yajun Wang

2016-11-14

Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses

Katelyn T Gause, Yan Yan, Neil M O'Brien-Simpson, Jiwei Cui, Jason C Lenzo, Eric C Reynolds, Frank Caruso

2016-11-02

Vaccine adjuvants that can induce robust protective immunity are highly sought after for the development of safer and more effecti..

Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea

Andrew K Wise, Justin Tan, Yajun Wang, Frank Caruso, Robert K Shepherd

2016-10-27

Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf ..

Dynamic Flow Impacts Cell-Particle Interactions: Sedimentation and Particle Shape Effects

Mattias Bjornmalm, Matthew Faria, Xi Chen, Jiwei Cui, Frank Caruso

2016-10-25

The interaction of engineered particles with biological systems determines their performance in biomedical applications. Although ..

Metal-Phenolic Supramolecular Gelation

Md Arifur Rahim, Mattias Bjornmalm, Tomoya Suma, Matthew Faria, Yi Ju, Kristian Kempe, Markus Muellner, Hirotaka Ejima, Anthony D Stickland, Frank Caruso

2016-10-24

Materials assembled by coordination interactions between naturally abundant polyphenols and metals are of interest for a wide rang..

Metal-Phenolic Supramolecular Gelation

Md Arifur Rahim, Mattias Björnmalm, Tomoya Suma, Matthew Faria, Yi Ju, Kristian Kempe, Markus Müllner, Hirotaka Ejima, Anthony D Stickland, Frank Caruso

2016-10-24

Increasing the Impact of Materials in and beyond Bio-Nano Science

Mattias Bjornmalm, Matthew Faria, Frank Caruso

2016-10-19

This is an exciting time for the field of bio-nano science: enormous progress has been made in recent years, especially in academi..

Polymer Capsules for Plaque-Targeted In Vivo Delivery

Joseph J Richardson, Mei Y Choy, Junling Guo, Kang Liang, Karen Alt, Yuan Ping, Jiwei Cui, Lok S Law, Christoph E Hagemeyer, Frank Caruso

2016-09-21

Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of ..

Improving Targeting of Metal-Phenolic Capsules by the Presence of Protein Coronas

Yi Ju, Qiong Dai, Jiwei Cui, Yunlu Dai, Tomoya Suma, Joseph J Richardson, Frank Caruso

2016-09-07

Particles adsorb proteins when they enter a physiological environment; this results in a surface coating termed a "protein corona"..

Void Engineering in Metal-Organic Frameworks via Synergistic Etching and Surface Functionalization

Ming Hu, Yi Ju, Kang Liang, Tomoya Suma, Jiwei Cui, Frank Caruso

2016-08-23

The rational design and engineering of metal–organic framework (MOF) crystals with hollow features has been used for various appli..

Synthesis of Discrete Alkyl-Silica Hybrid Nanowires and Their Assembly into Nanostructured Superhydrophobic Membranes

Deliang Yi, Chenglong Xu, Ruidie Tang, Xuehua Zhang, Frank Caruso, Yajun Wang

2016-07-11

We report the synthesis of highly flexible and mechanically robust hybrid silica nanowires (NWs) which can be used as novel buildi..

Synthesis of Discrete Alkyl‐Silica Hybrid Nanowires and Their Assembly into Nanostructured Superhydrophobic Membranes

Deliang Yi, Chenglong Xu, Ruidie Tang, Xuehua Zhang, Frank Caruso, Yajun Wang

2016-07-11

Engineered Metal-Phenolic Capsules Show Tunable Targeted Delivery to Cancer Cells

Yi Ju, Jiwei Cui, Huanli Sun, Markus Mullner, Yunlu Dai, Junling Guo, Nadja Bertleff-Zieschang, Tomoya Suma, Joseph J Richardson, Frank Caruso

2016-06-01

We engineered metal-phenolic capsules with both high targeting and low nonspecific cell binding properties. The capsules were prep..

Nanoengineered Templated Polymer Particles: Navigating the Biological Realm

Jiwei Cui, Joseph J Richardson, Mattias Bjornmalm, Matthew Faria, Frank Caruso

2016-06-01

Nanoengineered materials offer tremendous promise for developing the next generation of therapeutics. We are transitioning from si..

Immobilized Particle Imaging for Quantification of Nano- and Microparticles

Jiwei Cui, Benjamin Hibbs, Sylvia T Gunawan, Julia A Braunger, Xi Chen, Joseph J Richardson, Eric Hanssen, Frank Caruso

2016-04-12

The quantification of nano- and microparticles is critical for diverse applications relying on the exact knowledge of the particle..

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Yu-Yen Chen, William Singleton, Katelyn T Gause, Yan Yan, Frank Caruso, Eric C Reynolds

2016-04-01

Highly purified outer membrane vesicles (OMVs) of the periodontal pathogens, Porphyromonas gingivalis, Treponema denticola and Tan..

Thermally Induced Charge Reversal of Layer-by-Layer Assembled Single-Component Polymer Films

Joseph J Richardson, Blaise L Tardy, Hirotaka Ejima, Junling Guo, Jiwei Cui, Kang Liang, Gwan H Choi, Pil J Yoo, Bruno G De Geest, Frank Caruso

2016-03-23

Temperature can be harnessed to engineer unique properties for materials useful in various contexts and has been shown to affect t..

Photocontrolled Cargo Release from Dual Cross-Linked Polymer Particles

Shereen Tan, Jiwei Cui, Qiang Fu, Eunhyung Nam, Katharina Ladewig, Jing M Ren, Edgar HH Wong, Frank Caruso, Anton Blencowe, Greg G Qiao

2016-03-09

Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. Th..

Shape-Dependent Activation of Cytokine Secretion by Polymer Capsules in Human Monocyte-Derived Macrophages

Xi Chen, Yan Yan, Markus Muellner, Yuan Ping, Jiwei Cui, Kristian Kempe, Christina Cortez-Jugo, Frank Caruso

2016-03-01

Particles with tailored geometries have received significant attention due to their specific interactions with biological systems...

Engineering Polymer Hydrogel Nanoparticles for Lymph Node-Targeted Delivery

Stefaan De Koker, Jiwei Cui, Nane Vanparijs, Lorenzo Albertazzi, Johan Grooten, Frank Caruso, Bruno G De Geest

2016-01-22

Analysing intracellular deformation of polymer capsules using structured illumination microscopy

Xi Chen, Jiwei Cui, Huanli Sun, Markus Mullner, Yan Yan, Ka Fung Noi, Yuan Ping, Frank Caruso

2016-01-01

Understanding the behaviour of therapeutic carriers is important in elucidating their mechanism of action and how they are process..

Engineering Polymer Hydrogel Nanoparticles for Lymph Node-Targeted Delivery

S De Koker, J Cui, N Vanparijs, L Albertazzi, J Grooten, F Caruso, BG De Geest

2016-01-01

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The induction of antigen-specific adaptive immunity exclusively occurs in lymph..

Nanoparticles assembled via pH-responsive reversible segregation of cyclodextrins in polyrotaxanes

Blaise L Tardy, Shereen Tan, Henk H Dam, Hirotaka Ejima, Anton Blencowe, Greg G Qiao, Frank Caruso

2016-01-01

Supramolecular polymers with monomers bound together by secondary interactions, such as polyrotaxanes (PRXs), consisting of alpha ..

Probing cell internalisation mechanics with polymer capsules

Xi Chen, Jiwei Cui, Yuan Ping, Tomoya Suma, Francesca Cavalieri, Quinn A Besford, George Chen, Julia A Braunger, Frank Caruso

2016-01-01

We report polymer capsule-based probes for quantifying the pressure exerted by cells during capsule internalisation (Pin). Poly(me..

Assembly-Controlled Permeability of Layer-by-Layer Polymeric Microcapsules Using a Tapered Fluidized Bed

Ka Fung Noi, Ah Roozmand, Mattias Bjoernmalm, Joseph J Richardson, George V Franks, Frank Caruso

2015-12-23

Nano- and microcapsules engineered through layer-by-layer (LbL) assembly are finding an increasingly large number of applications ..

Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model

Huanli Sun, Mattias Bjoernmalm, Jiwei Cui, Edgar HH Wong, Yunlu Dai, Qiong Dai, Greg G Qiao, Frank Caruso

2015-11-01

Particle stiffness is a design parameter that affects bionano interactions, including biodistribution kinetics and cellular proces..

Targeting Ability of Affibody-Functionalized Particles Is Enhanced by Albumin but Inhibited by Serum Coronas

Qiong Dai, Yan Yan, Junling Guo, Mattias Bjoernmalm, Jiwei Cui, Huanli Sun, Frank Caruso

2015-11-01

Protein coronas formed on engineered particles can alter their targeting ability as they enter biological environments. Here, we e..

Nanoporous Metal–Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide

J Guo, X Wang, DC Henstridge, JJ Richardson, J Cui, A Sharma, MA Febbraio, K Peter, JB de Haan, CE Hagemeyer, F Caruso

2015-10-01

Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense FeIII -TA complexes in nanoporo..

Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Sylvia T Gunawan, Kristian Kempe, Thomas Bonnard, Jiwei Cui, Karen Alt, Lok S Law, Xiaowei Wang, Erik Westein, Georgina K Such, Karlheinz Peter, Christoph E Hagemeyer, Frank Caruso

2015-09-16

Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the su..

Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols

Junling Guo, Huanli Sun, Karen Alt, Blaise L Tardy, Joseph J Richardson, Tomoya Suma, Hirotaka Ejima, Jiwei Cui, Christoph E Hagemeyer, Frank Caruso

2015-08-26

Dual-responsive boronate-phenolic network (BPN) capsules are fabricated by the complexation of phenylborate and phenolic materials..

Flow-Based Assembly of Layer-by-Layer Capsules through Tangential Flow Filtration

Mattias Bjoernmalm, All Roozmand, Ka Fung Noi, Junling Guo, Jiwei Cui, Joseph J Richardson, Frank Caruso

2015-08-25

Layer-by-layer (LbL) assembly on nano- and microparticles is of interest for a range of applications, including catalysis, optics,..

Surface-Confined Amorphous Films from Metal-Coordinated Simple Phenolic Ligands

Md Arifur Rahim, Kristian Kempe, Markus Muellner, Hirotaka Ejima, Yi Ju, Martin P van Koeverden, Tomoya Suma, Julia A Braunger, Michael G Leeming, Brendan F Abrahams, Frank Caruso

2015-08-25

Coordination chemistry of natural polyphenols and transition metals allows rapid self-assembly of conformal coatings on diverse su..

Capsosomes as Long-Term Delivery Vehicles for Protein Therapeutics.

JW Maina, JJ Richardson, R Chandrawati, K Kempe, MP van Koeverden, F Caruso

2015-07-09

We report the preparation of polymer capsules containing liposomal subcompartments, termed capsosomes, and their ability for the s..

Redox-Sensitive PEG-Polypeptide Nanoporous Particles for Survivin Silencing in Prostate Cancer Cells

Francesca Cavalieri, Giovanni L Beretta, Jiwei Cui, Julia A Braunger, Yan Yan, Joseph J Richardson, Stella Tinelli, Marco Folini, Nadia Zaffaroni, Frank Caruso

2015-07-01

We report the engineering of intracellular redox-responsive nanoporous poly(ethylene glycol)-poly(l-lysine) particles (NPEG-PLLs)...

pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery

Yuan Ping, Junling Guo, Hirotaka Ejima, Xi Chen, Joseph J Richardson, Huanli Sun, Frank Caruso

2015-05-06

A new class of pH-responsive capsules based on metal-phenolic networks (MPNs) for anticancer drug loading, delivery and release is..

Technology-driven layer-by-layer assembly of nanofilms

Joseph J Richardson, Mattias Bjoernmalm, Frank Caruso

2015-04-24

Multilayer thin films have garnered intense scientific interest due to their potential application in diverse fields such as catal..

Interfacing Materials Science and Biology for Drug Carrier Design

Georgina K Such, Yan Yan, Angus PR Johnston, Sylvia T Gunawan, Frank Caruso

2015-04-08

Over the last ten years, there has been considerable research interest in the development of polymeric carriers for biomedicine. S..

Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks

Yi Ju, Jiwei Cui, Markus Muellner, Tomoya Suma, Ming Hu, Frank Caruso

2015-03-01

Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strat..

Monoclonal Antibody-Functionalized Multilayered Particles: Targeting Cancer Cells in the Presence of Protein Coronas

Qiong Dai, Yan Yan, Ching-Seng Ang, Kristian Kempe, Marloes MJ Kamphuis, Sarah J Dodds, Frank Caruso

2015-03-01

Engineered particles adsorb biomolecules (e.g., proteins) when introduced in a biological medium to form a layer called a "corona"..

Physicochemical and Immunological Assessment of Engineered Pure Protein Particles with Different Redox States

Katelyn T Gause, Yan Yan, Jiwei Cui, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Frank Caruso

2015-03-01

The development of subunit antigen delivery formulations has become an important research endeavor, especially in cases where a wh..

Engineering Poly(ethylene glycol) Particles for Improved Biodistribution

Jiwei Cui, Robert De Rose, Karen Alt, Sheilajen Alcantara, Brett M Paterson, Kang Liang, Ming Hu, Joseph J Richardson, Yan Yan, Charmaine M Jeffery, Roger I Price, Karlheinz Peter, Christoph E Hagemeyer, Paul S Donnelly, Stephen J Kent, Frank Caruso

2015-02-01

We report the engineering of poly(ethylene glycol) (PEG) hydrogel particles using a mesoporous silica (MS) templating method via t..

Generalizable Strategy for Engineering Protein Particles with pH-Triggered Disassembly and Recoverable Protein Functionality

Tomoya Suma, Jiwei Cui, Markus Muellner, Yi Ju, Junling Guo, Ming Hu, Frank Caruso

2015-02-01

Protein particles are promising candidates for therapeutic delivery. In this study, we report a generalizable strategy to assemble..

Size and Rigidity of Cylindrical Polymer Brushes Dictate Long Circulating Properties In Vivo

Markus Muellner, Sarah J Dodds, Nguyen Tri-Hung, Danielle Senyschyn, Christopher JH Porter, Ben J Boyd, Frank Caruso

2015-02-01

Studies of spherical nanoengineered drug delivery systems have suggested that particle size and mechanical properties are key dete..

The "Sweet" Side of the Protein Corona: Effects of Glycosylation on Nanoparticle-Cell Interactions

Sha Wan, Philip M Kelly, Eugene Mahon, Henning Stockmann, Pauline M Rudd, Frank Caruso, Kenneth A Dawson, Yan Yan, Marco P Monopoli

2015-02-01

The significance of a protein corona on nanoparticles in modulating particle properties and their biological interactions has been..

Versatile Loading of Diverse Cargo into Functional Polymer Capsules

Joseph J Richardson, James W Maina, Hirotaka Ejima, Ming Hu, Junling Guo, Mei Y Choy, Sylvia T Gunawan, Lien Lybaert, Christoph E Hagemeyer, Bruno G De Geest, Frank Caruso

2015-02-01

Polymer microcapsules are of particular interest for applications including self-healing coatings, catalysis, bioreactions, sensin..

Fabrication of ultra-thin polyrotaxane-based films via solid-state continuous assembly of polymers

Shereen Tan, Eunhyung Nam, Jiwei Cui, Chenglong Xu, Qiang Fu, Jing M Ren, Edgar HH Wong, Katharina Ladewig, Frank Caruso, Anton Blencowe, Greg G Qiao

2015-01-01

Surface-confined ultra-thin polyrotaxane (PRX)-based films with tunable composition, surface topology and swelling characteristics..

The role of capsule stiffness on cellular processing

Huanli Sun, Edgar HH Wong, Yan Yan, Jiwei Cui, Qiong Dai, Junling Guo, Greg G Qiao, Frank Caruso

2015-01-01

Particle stiffness is emerging as an important parameter in determining the cell uptake dynamics of particles. Understanding the e..

Unravelling "off-target" effects of redox-active polymers and polymer multilayered capsules in prostate cancer cells

Giovanni L Beretta, Marco Folini, Francesca Cavalieri, Yan Yan, Enrico Fresch, Subramanian Kaliappan, Christoph Hasenhoerl, Joseph J Richardson, Stella Tinelli, Andreas Fery, Frank Caruso, Nadia Zaffaroni

2015-01-01

Redox-active polymers and carriers are oxidizing nanoagents that can potentially trigger intracellular off-target effects. In the ..

Tuning Particle Biodegradation through Polymer-Peptide Blend Composition

Sylvia T Gunawan, Kristian Kempe, Georgina K Such, Jiwei Cui, Kang Liang, Joseph J Richardson, Angus PR Johnston, Frank Caruso

2014-12-01

We report the preparation of polymer-peptide blend replica particles via the mesoporous silica (MS) templated assembly of poly(eth..

Super-Soft Hydrogel Particles with Tunable Elasticity in a Microfluidic Blood Capillary Model

Jiwei Cui, Mattias Bjoernmalm, Kang Liang, Chenglong Xu, James P Best, Xuehua Zhang, Frank Caruso

2014-11-19

Super-soft PEG hydrogel particles with tunable elasticity are prepared via a mesoporous silica templating method. The deformabilit..

Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery

Y Wang, JW Maina, F Caruso, AK Wise, RK Shepherd, J Tan

2014-11-12

Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force ..

A Cytoprotective and Degradable Metal-Polyphenol Nanoshell for Single-Cell Encapsulation

Ji Hun Park, Kyunghwan Kim, Juno Lee, Ji Yu Choi, Daewha Hong, Sung Ho Yang, Frank Caruso, Younghoon Lee, Insung S Choi

2014-11-10

A Cytoprotective and Degradable Metal-Polyphenol Nanoshell for Single-Cell Encapsulation

Ji Hun Park, Kyunghwan Kim, Juno Lee, Ji Yu Choi, Daewha Hong, Sung Ho Yang, Frank Caruso, Younghoon Lee, Insung S Choi

2014-11-10

Single-cell encapsulation promises the cytoprotection of the encased cells against lethal stressors, reminiscent of the sporulatio..

Convective polymer assembly for the deposition of nanostructures and polymer thin films on immobilized particles

Joseph J Richardson, Mattias Bjoernmalm, Sylvia T Gunawan, Junling Guo, Kang Liang, Blaise Tardy, Shota Sekiguchi, Ka Fung Noi, Jiwei Cui, Hirotaka Ejima, Frank Caruso

2014-11-01

We report the preparation of polymer particles via convective polymer assembly (CPA). Convection is used to move polymer solutions..

Fabrication of Chiral Stationary Phases via Continuous Assembly of Polymers for Resolution of Enantiomers by Liquid Chromatography

Stefanie N Guntari, Eunhyung Nam, Nina N Pranata, Kenneth Chia, Edgar HH Wong, A Blencowe, Tor K Goh, Frank Caruso, Greg G Qiao

2014-11-01

Precise stereochemical determination of chiral molecules is highly important, especially in the pharmaceutical industry where one ..

Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs

James W Maina, Jiwei Cui, Mattias Bjoernmalm, Andrew K Wise, Robert K Shepherd, Frank Caruso

2014-11-01

This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demo..

Engineering Enzyme-Cleavable Hybrid Click Capsules with a pH-Sheddable Coating for Intracellular Degradation

Sylvia T Gunawan, Kang Liang, Georgina K Such, Angus PR Johnston, Melissa KM Leung, Jiwei Cui, Frank Caruso

2014-10-29

The engineering of layer-by-layer (LbL) hybrid click capsules that are responsive to biological stimuli is reported. The capsules ..

Intracellularly Degradable Hydrogen-Bonded Polymer Capsules

Kristian Kempe, Sher Leen Ng, Sylvia T Gunawan, Ka Fung Noi, Frank Caruso

2014-10-22

The assembly of low-fouling polymer capsules with redox-responsive behavior and intracellular degradability is reported. Thiol-con..

Endocytic Capsule Sensors for Probing Cellular Internalization

Kang Liang, Sylvia T Gunawan, Joseph J Richardson, Georgina K Such, Jiwei Cui, Frank Caruso

2014-10-01

A new class of polymer capsules with an in-built endocytic pH-coupled fluorescence switch is reported. These capsules display reve..

Engineering and evaluating drug delivery particles in microfluidic devices

Mattias Bjoernmalm, Yan Yan, Frank Caruso

2014-09-28

The development of new and improved particle-based drug delivery is underpinned by an enhanced ability to engineer particles with ..

Continuous assembly of polymers via solid phase reactions

Eunhyung Nam, Jinguk Kim, Stefanie N Guntari, Helga Seyler, Qiang Fu, Edgar HH Wong, Anton Blencowe, David J Jones, Frank Caruso, Greg G Qiao

2014-09-01

The continuous assembly of polymers in the solid state via ring-opening metathesis polymerization (ssCAPROMP) is reported as an ef..

Fluidized Bed Layer-by-Layer Microcapsule Formation

Joseph J Richardson, Darwin Teng, Mattias Bjoernmalm, Sylvia T Gunawan, Junling Guo, Jiwei Cui, George V Franks, Frank Caruso

2014-08-26

Polymer microcapsules can be used as bioreactors and artificial cells; however, preparation methods for cell-like microcapsules ar..

Phenolic film engineering for template-mediated microcapsule preparation

Hirotaka Ejima, Joseph J Richardson, Frank Caruso

2014-08-01

Microcapsules are of scientific and technological interest because of their ability to encapsulate cargo inside their hollow inter..

Programmed Degradation of DNA Multilayer Films

Lillian Lee, Angus PR Johnston, Frank Caruso

2014-07-23

The design and assembly of DNA multilayer films with programmable degradation properties are reported. The nanostructured DNA film..

Fundamental Studies of Hybrid Poly(2-(diisopropylamino)ethyl methacrylate)/Poly(N-vinylpyrrolidone) Films and Capsules

Sher Leen Ng, James P Best, Kristian Kempe, Kang Liang, Angus PR Johnston, Georgina K Such, Frank Caruso

2014-07-01

Hybrid and multicompartment carriers are of significant interest for the development of next-generation therapeutic drug carriers...

Surface-Initiated Polymerization within Mesoporous Silica Spheres for the Modular Design of Charge-Neutral Polymer Particles

Markus Muellner, Jiwei Cui, Ka Fung Noi, Sylvia T Gunawan, Frank Caruso

2014-06-03

We report a templating approach for the preparation of functional polymer replica particles via surface-initiated polymerization i..

Engineering Multifunctional Capsules through the Assembly of Metal-Phenolic Networks

Junling Guo, Yuan Ping, Hirotaka Ejima, Karen Alt, Mirko Meissner, Joseph J Richardson, Yan Yan, Karlheinz Peter, Dominik von Elverfeldt, Christoph E Hagemeyer, Frank Caruso

2014-05-26

Emerging methods for the fabrication of polymer capsules

Jiwei Cui, Martin P van Koeverden, Markus Muellner, Kristian Kempe, Frank Caruso

2014-05-01

Hollow polymer capsules are attracting increasing research interest due to their potential application as drug delivery vectors, s..

Engineering Multifunctional Capsules through the Assembly of Metal-Phenolic Networks

Junling Guo, Yuan Ping, Hirotaka Ejima, Karen Alt, Mirko Meissner, Joseph J Richardson, Yan Yan, Karlheinz Peter, Dominik von Elverfeldt, Christoph E Hagemeyer, Frank Caruso

2014-05-01

Metal-organic coordination materials are of widespread interest because of the coupled benefits of inorganic and organic building ..

In vivo imaging and tracking of individual nanodiamonds in drosophila melanogaster embryos

David A Simpson, Amelia J Thompson, Mark Kowarsky, Nida F Zeeshan, Michael SJ Barson, Liam T Hall, Yan Yan, Stefan Kaufmann, Brett C Johnson, Takeshi Ohshima, Frank Caruso, Robert E Scholten, Robert B Saint, Michael J Murray, Lloyd CL Hollenberg

2014-04-01

In this work, we incorporate and image individual fluorescent nanodiamonds in the powerful genetic model system Drosophila melanog..

Peptide-Tunable Drug Cytotoxicity via One-Step Assembled Polymer Nanoparticles

Kang Liang, Joseph J Richardson, Hirotaka Ejima, Georgina K Such, Jiwei Cui, Frank Caruso

2014-04-01

A novel class of nanoparticles is developed for the co-delivery of a short cell penetrating peptide and a chemotherapeutic drug to..

Engineering Fluorescent Poly(dopamine) Capsules

Xi Chen, Yan Yan, Markus Muellner, Martin P van Koeverden, Ka Fung Noi, Wei Zhu, Frank Caruso

2014-03-18

The recent development of poly(dopamine) (PDA) capsules provides new opportunities for their application in biology and medicine. ..

Endocytic pH-Triggered Degradation of Nanoengineered Multilayer Capsules

Kang Liang, Georgina K Such, Angus PR Johnston, Zhiyuan Zhu, Hirotaka Ejima, Joseph J Richardson, Jiwei Cui, Frank Caruso

2014-03-01

The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specif..

Coordination-Driven Multistep Assembly of Metal-Polyphenol Films and Capsules

Md Arifur Rahim, Hirotaka Ejima, Kwun Lun Cho, Kristian Kempe, Markus Muellner, James P Best, Frank Caruso

2014-02-25

We report the assembly of metal-polyphenol complex (MPC) films and capsules through the sequential deposition of iron(III) ions (F..

Assembly of Layer-by-Layer Particles and Their Interactions with Biological Systems

Yan Yan, Mattias Bjoenmalm, Frank Caruso

2014-01-14

Multilayered polymer particles with a wide range of properties can be precisely engineered via the layer-by-layer technique using ..

Nanoscale engineering of low-fouling surfaces through polydopamine immobilisation of zwitterionic peptides

Jiwei Cui, Yi Ju, Kang Liang, Hirotaka Ejima, Samuel Loercher, Katelyn T Gause, Joseph J Richardson, Frank Caruso

2014-01-01

We report a versatile approach for the design of substrate-independent low-fouling surfaces via mussel-inspired immobilisation of ..

Self-Assembled Stimuli-Responsive Polyrotaxane Core-Shell Particles

Blaise L Tardy, Henk H Dam, Marloes MJ Kamphuis, Joseph J Richardson, Frank Caruso

2014-01-01

Thermodynamically assembled core-shell nanocarriers are potential candidates for drug delivery applications due to their submicrom..

Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging

Damien Mertz, Christine Affolter-Zbaraszczuk, Julien Barthes, Jiwei Cui, Frank Caruso, Thomas F Baumert, Jean-Claude Voegel, Joelle Ogier, Florent Meyer

2014-01-01

In this article, we address the design of innovative human serum albumin (HSA)-based nanoparticles loaded with silencing RNA and g..

Clickable Poly(2-oxazoline) Architectures for the Fabrication of Low-Fouling Polymer Capsules

Kristian Kempe, Sher Leen Ng, Ka Fung Noi, Markus Muellner, Sylvia T Gunawan, Frank Caruso

2013-12-01

Hollow polymer capsules were prepared from linear as well as brushlike poly(2-oxazoline)s (POxs). Linear POxs containing alkene fu..

Differential Roles of the Protein Corona in the Cellular Uptake of Nanoporous Polymer Particles by Monocyte and Macrophage Cell Lines

Yan Yan, Katelyn T Gause, Marloes MJ Kamphuis, Ching-Seng Ang, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Edouard C Nice, Frank Caruso

2013-12-01

Many biomolecules, mainly proteins, adsorb onto polymer particles to form a dynamic protein corona in biological environments. The..

Immersive Polymer Assembly on Immobilized Particles for Automated Capsule Preparation

Joseph J Richardson, Kang Liang, Kristian Kempe, Hirotaka Ejima, Jiwei Cui, Frank Caruso

2013-12-01

We report a versatile approach for polymer capsule preparation using immobilized particles, which are immersed into polymer soluti..

Mechanical Characterization of Ultrasonically Synthesized Microbubble Shells by Flow Cytometry and AFM

Francesca Cavalieri, James P Best, Camilo Perez, Juan Tu, Frank Caruso, Thomas J Matula, Muthupandian Ashokkumar

2013-11-13

The mechanical properties of the shell of ultrasonically synthesized lysozyme microbubbles, LSMBs, were evaluated by acoustic inte..

Advanced Subcompartmentalized Microreactors: Polymer Hydrogel Carriers Encapsulating Polymer Capsules and Liposomes

Leticia Hosta-Rigau, Olga Shimoni, Brigitte Stadler, Frank Caruso

2013-11-11

The design of compartmentalized carriers for advanced drug delivery systems or artificial cells and organelles is of interest for ..

Particle Carriers for Combating Multidrug-Resistant Cancer

Yan Yan, Mattias Bjoernmalm, Frank Caruso

2013-11-01

Multidrug resistance (MDR) in tumors accounts for significant treatment failure. Particle carriers offer potential benefits for tr..

Layer-by-Layer Polymer Coating on Discrete Particles of Cubic Lyotropic Liquid Crystalline Dispersions (Cubosomes)

Chantelle D Driever, Xavier Mulet, Lynne J Waddington, Almar Postma, Helmut Thissen, Frank Caruso, Calum J Drummond

2013-10-22

Cubic phase lyotropic liquid crystalline colloidal dispersions (cubosomes) were surface-modified with seven polyelectrolyte layers..

Assembly of Nanostructured Films with Hydrophobic Subcompartments via Continuous Assembly of Polymers

Edgar HH Wong, Martin P van Koeverden, Eunhyung Nam, Stefanie N Guntari, Steven Harris Wibowo, Anton Blencowe, Frank Caruso, Greg G Qiao

2013-10-08

The generation of nanoscale polymer films using complex, hierarchically structured (bio)macromolecular architectures has important..

Near-Incompressible Faceted Polymer Microcapsules from Metal-Organic Framework Templates

Hirotaka Ejima, Nobuhiro Yanai, James P Best, Melinda Sindoro, Steve Granick, Frank Caruso

2013-10-01

Faceted polymer microcapsules are prepared from metal-organic framework (MOF) templates. The MOF templates are removable under mil..

Assembly of Free-Standing Polypeptide Films via the Synergistic Combination of Hyperbranched Macroinitiators, the Grafting-From Approach, and Cross-Chain Termination

Steven Harris Wibowo, Edgar HH Wong, Adrian Sulistio, Stefanie N Guntari, Anton Blencowe, Frank Caruso, Greg G Qiao

2013-09-06

Cross-linked polypeptide-based films are fabricated via a novel and robust method employing surface-initiated ring opening polymer..

Mechanics of pH-Responsive Hydrogel Capsules

James P Best, Martin P Neubauer, Sameen Javed, Henk H Dam, Andreas Fery, Frank Caruso

2013-08-06

While soft hydrogel nano- and microstructures hold great potential for therapeutic treatments and in vivo applications, their nano..

Tuning the Mechanical Properties of Nanoporous Hydrogel Particles via Polymer Cross-Linking

James P Best, Jiwei Cui, Markus Muellner, Frank Caruso

2013-08-06

Soft hydrogel particles with tunable mechanical properties are promising for next-generation therapeutic applications. This is due..

Low-Fouling, Biospecific Films Prepared by the Continuous Assembly of Polymers

Stefanie N Guntari, Edgar HH Wong, Tor K Goh, Rona Chandrawati, Anton Blencowe, Frank Caruso, Greg G Qiao

2013-08-01

We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a..

One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering

Hirotaka Ejima, Joseph J Richardson, Kang Liang, James P Best, Martin P van Koeverden, Georgina K Such, Jiwei Cui, Frank Caruso

2013-07-12

The development of facile and versatile strategies for thin-film and particle engineering is of immense scientific interest. Howev..

Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles

Jiwei Cui, Robert De Rose, James P Best, Angus PR Johnston, Sheilajen Alcantara, Kang Liang, Georgina K Such, Stephen J Kent, Frank Caruso

2013-07-05

DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elast..

Detection of atomic spin labels in a lipid bilayer using a single-spin nanodiamond probe

Stefan Kaufmann, David A Simpson, Liam T Hall, Viktor Perunicic, Philipp Senn, Steffen Steinert, Liam P McGuinness, Brett C Johnson, Takeshi Ohshima, Frank Caruso, Joerg Wrachtrup, Robert E Scholten, Paul Mulvaney, Lloyd Hollenberg

2013-07-02

Magnetic field fluctuations arising from fundamental spins are ubiquitous in nanoscale biology, and are a rich source of informati..

Formation and Degradation of Layer-by-Layer-Assembled Polyelectrolyte Polyrotaxane Capsules

Henk H Dam, Frank Caruso

2013-06-18

We report the preparation of degradable capsules via layer-by-layer assembly using polyelectrolyte (PE) polyrotaxanes (PRXs). The ..

Design of Degradable Click Delivery Systems

Georgina K Such, Sylvia T Gunawan, Kang Liang, Frank Caruso

2013-06-13

Click chemistry has had a significant impact in the field of materials science over the last 10 years, as it has enabled the desig..

Particles on the Move: Intracellular Trafficking and Asymmetric Mitotic Partitioning of Nanoporous Polymer Particles

Yan Yan, Zon W Lai, Robert JA Goode, Jiwei Cui, Tess Bacic, Marloes MJ Kamphuis, Edouard C Nice, Frank Caruso

2013-06-01

Nanoporous polymer particles (NPPs) prepared by mesoporous silica templating show promise as a new class of versatile drug/gene de..

Lysine functionalised amyloid fibrils: the design and assembly of a TTR1-based peptide

Marie N Bongiovanni, Frank Caruso, Sally L Gras

2013-01-01

Non-core residues can affect the formation and protofilament packing of fibrils assembled from short peptide sequences. These resi..

Multivalent Directed Assembly of Colloidal Particles

Hirotaka Ejima, Joseph J Richardson, Frank Caruso

2013-01-01

Sticking together: Colloidal particles with a determined number of sticky sites arranged in precise geometries analogous to atoms ..

Preparation of Nano- and Microcapsules by Electrophoretic Polymer Assembly

Joseph J Richardson, Hirotaka Ejima, Samuel L Loercher, Kang Liang, Philipp Senn, Jiwei Cui, Frank Caruso

2013-01-01

Slipping into a comfortable routine: Multilayered polymer thin films were assembled on particles immobilized in agarose by electro..

Shape-Dependent Cellular Processing of Polyelectrolyte Capsules

Olga Shimoni, Yan Yan, Yajun Wang, Frank Caruso

2013-01-01

Particle shape is emerging as a key design parameter for tailoring the interactions between particles and cells. Herein, we report..

Stiffness-mediated adhesion of cervical cancer cells to soft hydrogel films

James P Best, Sameen Javed, Joseph J Richardson, Kwun Lun Cho, Marloes MJ Kamphuis, Frank Caruso

2013-01-01

We report engineered hydrogel thin-films with varying degrees of covalent crosslinking, which demonstrate enhanced HeLa cell adhes..

Emerging Techniques in Proteomics for Probing Nano-Bio Interactions

Zon W Lai, Yan Yan, Frank Caruso, Edouard C Nice

2012-12-01

Nanoengineered particles that can facilitate drug formulation and improve specificity of delivery afford exciting opportunities fo..