ENGINEERING MATERIALS FOR ADVANCES IN NANOMEDICINE
Grant number: FL120100030 | Funding period: 2012 - 2017
Nanomedicine is one of the fastest growing areas in nanotechnology. This project will develop next-generation particle systems with engineered properties that are expected to underpin advances in the delivery of therapeutics in the areas of cancer, vaccines, cardiovascular disease and neural health.
Related publications (136)
Surface Modification of Spider Silk Particles to Direct Biomolecular Corona Formation.
Alessia CG Weiss, Heike M Herold, Sarah Lentz, Matthew Faria, Quinn A Besford, Ching-Seng Ang, Frank Caruso, Thomas Scheibel
In recent years, spider silk-based materials have attracted attention because of their biocompatibility, processability, and biode..
Ricocheting Droplets Moving on Super-Repellent Surfaces
Shuaijun Pan, Rui Guo, Joseph J Richardson, Joseph D Berry, Quinn A Besford, Mattias Bjornmalm, Gyeongwon Yun, Ruoxi Wu, Zhixing Lin, Qi-Zhi Zhong, Jiajing Zhou, Qiang Sun, Jianhua Li, Yanbing Lu, Zhichao Dong, Margaret Katherine Banks, Weijian Xu, Jianhui Jiang, Lei Jiang, Frank Caruso
Droplet bouncing on repellent solid surfaces (e.g., the lotus leaf effect) is a common phenomenon that has aroused interest in var..
Coatings super-repellent to ultralow surface tension liquids
Shuaijun Pan, Rui Guo, Mattias Bjornmalm, Joseph J Richardson, Ling Li, Chang Peng, Nadja Bertleff-Zieschang, Weijian Xu, Jianhui Jiang, Frank Caruso
High-performance coatings that durably and fully repel liquids are of interest for fundamental research and practical applications..
Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids
Marcin Wojnilowicz, Quinn A Besford, Yun-Long Wu, Xian Jun Loh, Julia A Braunger, Agata Glab, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri
The poor penetration of nanocarrier-siRNA constructs into tumor tissue is a major hurdle for the in vivo efficacy of siRNA therape..
Minimum information reporting in bio-nano experimental literature
Matthew Faria, Mattias Bjornmalm, Kristofer J Thurecht, Stephen J Kent, Robert G Parton, Maria Kavallaris, Angus PR Johnston, J Justin Gooding, Simon R Corrie, Ben J Boyd, Pall Thordarson, Andrew K Whittaker, Molly M Stevens, Clive A Prestidge, Christopher JH Porter, Wolfgang J Parak, Thomas P Davis, Edmund J Crampin, Frank Caruso
Studying the interactions between nanoengineered materials and biological systems plays a vital role in the development of biologi..
Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging
Thomas Bonnard, Anand Jayapadman, Jasmine A Putri, Jiwei Cui, Yi Ju, Catherine Carmichael, Thomas A Angelovich, Stephen H Cody, Shauna French, Karline Pascaud, Hannah A Pearce, Shweta Jagdale, Frank Caruso, Christoph E Hagemeyer
Nanomedicine holds great promise for vascular disease diagnosis and specific therapy, yet rapid sequestration by the mononuclear p..
Microfluidic Examination of the "Hard" Biomolecular Corona Formed on Engineered Particles in Different Biological Milieu
Alessia CG Weiss, Kristian Kempe, Stephan Foerster, Frank Caruso
The formation of a biomolecular corona around engineered particles determines, in large part, their biological behavior in vitro a..
Supramolecular Metal-Phenolic Gels for the Crystallization of Active Pharmaceutical Ingredients
Md Arifur Rahim, Yuuki Hata, Mattias Bjornmalm, Yi Ju, Frank Caruso
The use of supramolecular gel media for the crystallization of active pharmaceutical ingredients (APIs) is of interest for control..
Multiligand Metal-Phenolic Assembly from Green Tea Infusions
Md Arifur Rahim, Mattias Bjornmalm, Nadja Bertleff-Zieschang, Yi Ju, Srinivas Mettu, Michael G Leeming, Frank Caruso
The synthesis of hybrid functional materials using the coordination-driven assembly of metal-phenolic networks (MPNs) is of intere..
Synthesis of Metal Nanoparticles in Metal-Phenolic Networks: Catalytic and Antimicrobial Applications of Coated Textiles
Gyeongwon Yun, Shuaijun Pan, Ting-Yi Wang, Junling Guo, Joseph J Richardson, Frank Caruso
The synthesis of metal nanoparticle (NP)-coated textiles (nanotextiles) is achieved by a dipping process in water without toxic ch..
Electrochemical Behavior and Redox-Dependent Disassembly of Gallic Acid/Fe-III Metal-Phenolic Networks
Pavel V Cherepanov, Md Arifur Rahim, Nadja Bertleff-Zieschang, Md Abu Sayeed, Anthony P O'Mullane, Simon E Moulton, Frank Caruso
Metal-phenolic networks (MPNs) are a versatile class of organic-inorganic hybrid systems that are generating interest for applicat..
Particle Targeting in Complex Biological Media
Qiong Dai, Nadja Bertleff-Zieschang, Julia A Braunger, Mattias Bjornmalm, Christina Cortez-Jugo, Frank Caruso
Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, incl..
Probing Transcription Factor Binding Activity and Downstream Gene Silencing in Living Cells with a DNA Nanoswitch
A Bertucci, J Guo, N Oppmann, A Glab, F Ricci, F Caruso, F Cavalieri
Transcription factor DNA binding activity is of pivotal importance in living systems because of its primary involvement in the reg..
Influence of Ionic Strength on the Deposition of Metal-Phenolic Networks
Junling Guo, Joseph J Richardson, Quinn A Besford, Andrew J Christofferson, Yunlu Dai, Chien W Ong, Blaise L Tardy, Kang Liang, Gwan H Choi, Jiwei Cui, Pil J Yoo, Irene Yarovsky, Frank Caruso
Metal-phenolic networks (MPNs) are a versatile class of self-assembled materials that are able to form functional thin films on va..
Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution
Danzi Song, Jiwei Cui, Huanli Sun, Tri-Hung Nguyen, Sheilajen Alcantara, Robert De Rose, Stephen J Kent, Christopher JH Porter, Frank Caruso
Surface modification is frequently used to tailor the interactions of nanoparticles with biological systems. In many cases, the ch..
Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy
Yunlu Dai, Junling Guo, Ting-Yi Wang, Yi Ju, Andrew J Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J Richardson, Christoph E Hagemeyer, Karen Alt, Frank Caruso
Therapeutic nanoparticles hold clinical promise for cancer treatment by avoiding limitations of conventional pharmaceuticals. Here..
Role of the Protein Corona Derived from Human Plasma in Cellular Interactions between Nanoporous Human Serum Albumin Particles and Endothelial Cells
Mikhail V Zyuzin, Yan Yan, Raimo Hartmann, Katelyn T Gause, Moritz Nazarenus, Jiwei Cui, Frank Caruso, Wolfgang J Parak
The presence of a protein corona on various synthetic nanomaterials has been shown to strongly influence how they interact with ce..
An Enzyme-Coated Metal-Organic Framework Shell for Synthetically Adaptive Cell Survival
Kang Liang, Joseph J Richardson, Christian J Doonan, Xavier Mulet, Yi Ju, Jiwei Cui, Frank Caruso, Paolo Falcaro
A bioactive synthetic porous shell was engineered to enable cells to survive in an oligotrophic environment. Eukaryotic cells (yea..
Tuning the Properties of Polymer Capsules for Cellular Interactions
Huanli Sun, Jiwei Cui, Yi Ju, Xi Chen, Edgar HH Wong, Jenny Tran, Greg G Qiao, Frank Caruso
Particle-cell interactions are governed by, among other factors, the composition and surface properties of the particles. Herein, ..
A Partially Graphitic Mesoporous Carbon Membrane with Three Dimensionally Networked Nanotunnels for Ultrasensitive Electrochemical Detection
Cong Fu, Deliang Yi, Chao Deng, Xingdong Wang, Weijia Zhang, Yi Tang, Frank Caruso, Yajun Wang
A hierarchically porous partially graphitic carbon (HPGC) membrane with three-dimensionally networked nanotunnels is prepared and ..
Rust-Mediated Continuous Assembly of Metal-Phenolic Networks
Md Arifur Rahim, Mattias Bjoernmalm, Nadja Bertleff-Zieschang, Quinn Besford, Srinivas Mettu, Tomoya Suma, Matthew Faria, Frank Caruso
The use of natural compounds for preparing hybrid molecular films-such as surface coatings made from metal-phenolic networks (MPNs..
Lactosylated Glycogen Nanoparticles for Targeting Prostate Cancer Cells
Quinn A Besford, Marcin Wojnilowicz, Tomoya Suma, Nadja Bertleff-Zieschang, Frank Caruso, Francesca Cayalieri
Glyconanoparticles that exhibit multivalent binding to lectins are desirable for molecular recognition and therapeutic application..
Modulated Fragmentation of Proapoptotic Peptide Nanoparticles Regulates Cytotoxicity
Tomoya Suma, Jiwei Cui, Markus Muellner, Shiwei Fu, Jenny Tran, Ka Fung Noi, Yi Ju, Frank Caruso
Peptides perform a diverse range of physiologically important functions. The formulation of nanoparticles directly from functional..
Engineered Hydrogen-Bonded Glycopolymer Capsules and Their Interactions with Antigen Presenting Cells
Kristian Kempe, Sue D Xiang, Paul Wilson, Md Arifur Rahim, Yi Ju, Michael R Whittaker, David M Haddleton, Magdalena Plebanski, Frank Caruso, Thomas P Davis
Hollow glycopolymer microcapsules were fabricated by hydrogen-bonded layer-by-layer (LbL) assembly, and their interactions with a ..
Cell-Conditioned Protein Coronas on Engineered Particles Influence Immune Responses
Qiong Dai, Junling Guo, Yan Yan, Ching-Seng Ang, Nadja Bertleff-Zieschang, Frank Caruso
A protein corona, which forms on engineered particles as soon as they are introduced into biological environments, is known to pro..
Interactions between circulating nanoengineered polymer particles and extracellular matrix components in vitro
Julia A Braunger, Mattias Bjornmalm, Nathan A Isles, Jiwei Cui, Timothy MA Henderson, Andrea J O'Connor, Frank Caruso
The extracellular matrix (ECM) that surrounds cells in vivo represents a biological barrier for nanomaterials in biomedicine. Here..
Biofunctional metal-phenolic films from dietary flavonoids
Nadja Bertleff-Zieschang, Md Arifur Rahim, Yi Ju, Julia A Braunger, Tomoya Suma, Yunlu Dai, Shuaijun Pan, Francesca Cavalieri, Frank Caruso
We assembled dietary, bioactive flavonoids into a metal coordinated network to form thin, surface-bound films and hollow capsules,..
Nanoengineering Particles through Template Assembly
Mattias Bjoernmalm, Jiwei Cui, Nadja Berdeff-Zieschang, Danzi Song, Matthew Faria, Md Arifur Rahim, Frank Caruso
The nanoengineering of particles is of interest for both fundamental and applied science. How particles are made substantially aff..
Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery
Katelyn T Gause, Adam K Wheatley, Jiwei Cui, Yan Yan, Stephen J Kent, Frank Caruso
Despite the immense public health successes of immunization over the past century, effective vaccines are still lacking for global..
Patterned Poly(dopamine) Films for Enhanced Cell Adhesion
Xi Chen, Christina Cortez-Jugo, Gwan H Choi, Mattias Bjornmalm, Yunlu Dai, Pil J Yoo, Frank Caruso
Engineered materials that promote cell adhesion and cell growth are important in tissue engineering and regenerative medicine. In ..
Modular assembly of superstructures from polyphenol-functionalized building blocks
Junling Guo, Blaise L Tardy, Andrew J Christofferson, Yunlu Dai, Joseph J Richardson, Wei Zhu, Ming Hu, Yi Ju, Jiwei Cui, Raymond R Dagastine, Irene Yarovsky, Frank Caruso
The organized assembly of particles into superstructures is typically governed by specific molecular interactions or external dire..
A Framework to Account for Sedimentation and Diffusion in Particle-Cell Interactions
Jiwei Cui, Matthew Faria, Mattias Bjornmalm, Yi Ju, Tomoya Suma, Sylvia T Gunawan, Joseph J Richardson, Hamed Heidar, Sara Bals, Edmund J Crampin, Frank Caruso
In vitro experiments provide a solid basis for understanding the interactions between particles and biological systems. An importa..
Synthesis of Chemically Asymmetric Silica Nanobottles and Their Application for Cargo Loading and as Nanoreactors and Nanomotors
Deliang Yi, Qian Zhang, Yinghua Liu, Jiaying Song, Yi Tang, Frank Caruso, Yajun Wang
We report the synthesis of chemically asymmetric silica nanobottles (NBs) with a hydrophobic exterior surface (capped with 3-chlor..
Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses
Katelyn T Gause, Yan Yan, Neil M O'Brien-Simpson, Jiwei Cui, Jason C Lenzo, Eric C Reynolds, Frank Caruso
Vaccine adjuvants that can induce robust protective immunity are highly sought after for the development of safer and more effecti..
Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea
Andrew K Wise, Justin Tan, Yajun Wang, Frank Caruso, Robert K Shepherd
Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf ..
Dynamic Flow Impacts Cell-Particle Interactions: Sedimentation and Particle Shape Effects
Mattias Bjornmalm, Matthew Faria, Xi Chen, Jiwei Cui, Frank Caruso
The interaction of engineered particles with biological systems determines their performance in biomedical applications. Although ..
Metal-Phenolic Supramolecular Gelation
Md Arifur Rahim, Mattias Bjornmalm, Tomoya Suma, Matthew Faria, Yi Ju, Kristian Kempe, Markus Muellner, Hirotaka Ejima, Anthony D Stickland, Frank Caruso
Materials assembled by coordination interactions between naturally abundant polyphenols and metals are of interest for a wide rang..
Polymer Capsules for Plaque-Targeted In Vivo Delivery
Joseph J Richardson, Mei Y Choy, Junling Guo, Kang Liang, Karen Alt, Yuan Ping, Jiwei Cui, Lok S Law, Christoph E Hagemeyer, Frank Caruso
Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of ..
Improving Targeting of Metal-Phenolic Capsules by the Presence of Protein Coronas
Yi Ju, Qiong Dai, Jiwei Cui, Yunlu Dai, Tomoya Suma, Joseph J Richardson, Frank Caruso
Particles adsorb proteins when they enter a physiological environment; this results in a surface coating termed a "protein corona"..
Void Engineering in Metal-Organic Frameworks via Synergistic Etching and Surface Functionalization
Ming Hu, Yi Ju, Kang Liang, Tomoya Suma, Jiwei Cui, Frank Caruso
The rational design and engineering of metal–organic framework (MOF) crystals with hollow features has been used for various appli..
Synthesis of Discrete Alkyl-Silica Hybrid Nanowires and Their Assembly into Nanostructured Superhydrophobic Membranes
Deliang Yi, Chenglong Xu, Ruidie Tang, Xuehua Zhang, Frank Caruso, Yajun Wang
We report the synthesis of highly flexible and mechanically robust hybrid silica nanowires (NWs) which can be used as novel buildi..
Engineered Metal-Phenolic Capsules Show Tunable Targeted Delivery to Cancer Cells
Yi Ju, Jiwei Cui, Huanli Sun, Markus Mullner, Yunlu Dai, Junling Guo, Nadja Bertleff-Zieschang, Tomoya Suma, Joseph J Richardson, Frank Caruso
We engineered metal-phenolic capsules with both high targeting and low nonspecific cell binding properties. The capsules were prep..
Immobilized Particle Imaging for Quantification of Nano- and Microparticles
Jiwei Cui, Benjamin Hibbs, Sylvia T Gunawan, Julia A Braunger, Xi Chen, Joseph J Richardson, Eric Hanssen, Frank Caruso
The quantification of nano- and microparticles is critical for diverse applications relying on the exact knowledge of the particle..
Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens
Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Yu-Yen Chen, William Singleton, Katelyn T Gause, Yan Yan, Frank Caruso, Eric C Reynolds
Highly purified outer membrane vesicles (OMVs) of the periodontal pathogens, Porphyromonas gingivalis, Treponema denticola and Tan..
Thermally Induced Charge Reversal of Layer-by-Layer Assembled Single-Component Polymer Films
Joseph J Richardson, Blaise L Tardy, Hirotaka Ejima, Junling Guo, Jiwei Cui, Kang Liang, Gwan H Choi, Pil J Yoo, Bruno G De Geest, Frank Caruso
Temperature can be harnessed to engineer unique properties for materials useful in various contexts and has been shown to affect t..
Photocontrolled Cargo Release from Dual Cross-Linked Polymer Particles
Shereen Tan, Jiwei Cui, Qiang Fu, Eunhyung Nam, Katharina Ladewig, Jing M Ren, Edgar HH Wong, Frank Caruso, Anton Blencowe, Greg G Qiao
Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. Th..
Shape-Dependent Activation of Cytokine Secretion by Polymer Capsules in Human Monocyte-Derived Macrophages
Xi Chen, Yan Yan, Markus Muellner, Yuan Ping, Jiwei Cui, Kristian Kempe, Christina Cortez-Jugo, Frank Caruso
Particles with tailored geometries have received significant attention due to their specific interactions with biological systems...
Analysing intracellular deformation of polymer capsules using structured illumination microscopy
Xi Chen, Jiwei Cui, Huanli Sun, Markus Mullner, Yan Yan, Ka Fung Noi, Yuan Ping, Frank Caruso
Understanding the behaviour of therapeutic carriers is important in elucidating their mechanism of action and how they are process..
Nanoparticles assembled via pH-responsive reversible segregation of cyclodextrins in polyrotaxanes
Blaise L Tardy, Shereen Tan, Henk H Dam, Hirotaka Ejima, Anton Blencowe, Greg G Qiao, Frank Caruso
Supramolecular polymers with monomers bound together by secondary interactions, such as polyrotaxanes (PRXs), consisting of alpha ..
Probing cell internalisation mechanics with polymer capsules
Xi Chen, Jiwei Cui, Yuan Ping, Tomoya Suma, Francesca Cavalieri, Quinn A Besford, George Chen, Julia A Braunger, Frank Caruso
We report polymer capsule-based probes for quantifying the pressure exerted by cells during capsule internalisation (Pin). Poly(me..
Assembly-Controlled Permeability of Layer-by-Layer Polymeric Microcapsules Using a Tapered Fluidized Bed
Ka Fung Noi, Ah Roozmand, Mattias Bjoernmalm, Joseph J Richardson, George V Franks, Frank Caruso
Nano- and microcapsules engineered through layer-by-layer (LbL) assembly are finding an increasingly large number of applications ..
Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model
Huanli Sun, Mattias Bjoernmalm, Jiwei Cui, Edgar HH Wong, Yunlu Dai, Qiong Dai, Greg G Qiao, Frank Caruso
Particle stiffness is a design parameter that affects bionano interactions, including biodistribution kinetics and cellular proces..
Targeting Ability of Affibody-Functionalized Particles Is Enhanced by Albumin but Inhibited by Serum Coronas
Qiong Dai, Yan Yan, Junling Guo, Mattias Bjoernmalm, Jiwei Cui, Huanli Sun, Frank Caruso
Protein coronas formed on engineered particles can alter their targeting ability as they enter biological environments. Here, we e..
Nanoporous Metal–Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide
J Guo, X Wang, DC Henstridge, JJ Richardson, J Cui, A Sharma, MA Febbraio, K Peter, JB de Haan, CE Hagemeyer, F Caruso
Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense FeIII -TA complexes in nanoporo..
Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets
Sylvia T Gunawan, Kristian Kempe, Thomas Bonnard, Jiwei Cui, Karen Alt, Lok S Law, Xiaowei Wang, Erik Westein, Georgina K Such, Karlheinz Peter, Christoph E Hagemeyer, Frank Caruso
Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the su..
Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols
Junling Guo, Huanli Sun, Karen Alt, Blaise L Tardy, Joseph J Richardson, Tomoya Suma, Hirotaka Ejima, Jiwei Cui, Christoph E Hagemeyer, Frank Caruso
Dual-responsive boronate-phenolic network (BPN) capsules are fabricated by the complexation of phenylborate and phenolic materials..
Flow-Based Assembly of Layer-by-Layer Capsules through Tangential Flow Filtration
Mattias Bjoernmalm, All Roozmand, Ka Fung Noi, Junling Guo, Jiwei Cui, Joseph J Richardson, Frank Caruso
Layer-by-layer (LbL) assembly on nano- and microparticles is of interest for a range of applications, including catalysis, optics,..
Surface-Confined Amorphous Films from Metal-Coordinated Simple Phenolic Ligands
Md Arifur Rahim, Kristian Kempe, Markus Muellner, Hirotaka Ejima, Yi Ju, Martin P van Koeverden, Tomoya Suma, Julia A Braunger, Michael G Leeming, Brendan F Abrahams, Frank Caruso
Coordination chemistry of natural polyphenols and transition metals allows rapid self-assembly of conformal coatings on diverse su..
Redox-Sensitive PEG-Polypeptide Nanoporous Particles for Survivin Silencing in Prostate Cancer Cells
Francesca Cavalieri, Giovanni L Beretta, Jiwei Cui, Julia A Braunger, Yan Yan, Joseph J Richardson, Stella Tinelli, Marco Folini, Nadia Zaffaroni, Frank Caruso
We report the engineering of intracellular redox-responsive nanoporous poly(ethylene glycol)-poly(l-lysine) particles (NPEG-PLLs)...
pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery
Yuan Ping, Junling Guo, Hirotaka Ejima, Xi Chen, Joseph J Richardson, Huanli Sun, Frank Caruso
A new class of pH-responsive capsules based on metal-phenolic networks (MPNs) for anticancer drug loading, delivery and release is..
Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks
Yi Ju, Jiwei Cui, Markus Muellner, Tomoya Suma, Ming Hu, Frank Caruso
Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strat..
Monoclonal Antibody-Functionalized Multilayered Particles: Targeting Cancer Cells in the Presence of Protein Coronas
Qiong Dai, Yan Yan, Ching-Seng Ang, Kristian Kempe, Marloes MJ Kamphuis, Sarah J Dodds, Frank Caruso
Engineered particles adsorb biomolecules (e.g., proteins) when introduced in a biological medium to form a layer called a "corona"..
Physicochemical and Immunological Assessment of Engineered Pure Protein Particles with Different Redox States
Katelyn T Gause, Yan Yan, Jiwei Cui, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Frank Caruso
The development of subunit antigen delivery formulations has become an important research endeavor, especially in cases where a wh..
Engineering Poly(ethylene glycol) Particles for Improved Biodistribution
Jiwei Cui, Robert De Rose, Karen Alt, Sheilajen Alcantara, Brett M Paterson, Kang Liang, Ming Hu, Joseph J Richardson, Yan Yan, Charmaine M Jeffery, Roger I Price, Karlheinz Peter, Christoph E Hagemeyer, Paul S Donnelly, Stephen J Kent, Frank Caruso
We report the engineering of poly(ethylene glycol) (PEG) hydrogel particles using a mesoporous silica (MS) templating method via t..
Generalizable Strategy for Engineering Protein Particles with pH-Triggered Disassembly and Recoverable Protein Functionality
Tomoya Suma, Jiwei Cui, Markus Muellner, Yi Ju, Junling Guo, Ming Hu, Frank Caruso
Protein particles are promising candidates for therapeutic delivery. In this study, we report a generalizable strategy to assemble..
Size and Rigidity of Cylindrical Polymer Brushes Dictate Long Circulating Properties In Vivo
Markus Muellner, Sarah J Dodds, Nguyen Tri-Hung, Danielle Senyschyn, Christopher JH Porter, Ben J Boyd, Frank Caruso
Studies of spherical nanoengineered drug delivery systems have suggested that particle size and mechanical properties are key dete..
The "Sweet" Side of the Protein Corona: Effects of Glycosylation on Nanoparticle-Cell Interactions
Sha Wan, Philip M Kelly, Eugene Mahon, Henning Stockmann, Pauline M Rudd, Frank Caruso, Kenneth A Dawson, Yan Yan, Marco P Monopoli
The significance of a protein corona on nanoparticles in modulating particle properties and their biological interactions has been..
Versatile Loading of Diverse Cargo into Functional Polymer Capsules
Joseph J Richardson, James W Maina, Hirotaka Ejima, Ming Hu, Junling Guo, Mei Y Choy, Sylvia T Gunawan, Lien Lybaert, Christoph E Hagemeyer, Bruno G De Geest, Frank Caruso
Polymer microcapsules are of particular interest for applications including self-healing coatings, catalysis, bioreactions, sensin..
Fabrication of ultra-thin polyrotaxane-based films via solid-state continuous assembly of polymers
Shereen Tan, Eunhyung Nam, Jiwei Cui, Chenglong Xu, Qiang Fu, Jing M Ren, Edgar HH Wong, Katharina Ladewig, Frank Caruso, Anton Blencowe, Greg G Qiao
Surface-confined ultra-thin polyrotaxane (PRX)-based films with tunable composition, surface topology and swelling characteristics..
Unravelling "off-target" effects of redox-active polymers and polymer multilayered capsules in prostate cancer cells
Giovanni L Beretta, Marco Folini, Francesca Cavalieri, Yan Yan, Enrico Fresch, Subramanian Kaliappan, Christoph Hasenhoerl, Joseph J Richardson, Stella Tinelli, Andreas Fery, Frank Caruso, Nadia Zaffaroni
Redox-active polymers and carriers are oxidizing nanoagents that can potentially trigger intracellular off-target effects. In the ..
Tuning Particle Biodegradation through Polymer-Peptide Blend Composition
Sylvia T Gunawan, Kristian Kempe, Georgina K Such, Jiwei Cui, Kang Liang, Joseph J Richardson, Angus PR Johnston, Frank Caruso
We report the preparation of polymer-peptide blend replica particles via the mesoporous silica (MS) templated assembly of poly(eth..
Super-Soft Hydrogel Particles with Tunable Elasticity in a Microfluidic Blood Capillary Model
Jiwei Cui, Mattias Bjoernmalm, Kang Liang, Chenglong Xu, James P Best, Xuehua Zhang, Frank Caruso
Super-soft PEG hydrogel particles with tunable elasticity are prepared via a mesoporous silica templating method. The deformabilit..
A Cytoprotective and Degradable Metal-Polyphenol Nanoshell for Single-Cell Encapsulation
Ji Hun Park, Kyunghwan Kim, Juno Lee, Ji Yu Choi, Daewha Hong, Sung Ho Yang, Frank Caruso, Younghoon Lee, Insung S Choi
Single-cell encapsulation promises the cytoprotection of the encased cells against lethal stressors, reminiscent of the sporulatio..
Convective polymer assembly for the deposition of nanostructures and polymer thin films on immobilized particles
Joseph J Richardson, Mattias Bjoernmalm, Sylvia T Gunawan, Junling Guo, Kang Liang, Blaise Tardy, Shota Sekiguchi, Ka Fung Noi, Jiwei Cui, Hirotaka Ejima, Frank Caruso
We report the preparation of polymer particles via convective polymer assembly (CPA). Convection is used to move polymer solutions..
Fabrication of Chiral Stationary Phases via Continuous Assembly of Polymers for Resolution of Enantiomers by Liquid Chromatography
Stefanie N Guntari, Eunhyung Nam, Nina N Pranata, Kenneth Chia, Edgar HH Wong, A Blencowe, Tor K Goh, Frank Caruso, Greg G Qiao
Precise stereochemical determination of chiral molecules is highly important, especially in the pharmaceutical industry where one ..
Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs
James W Maina, Jiwei Cui, Mattias Bjoernmalm, Andrew K Wise, Robert K Shepherd, Frank Caruso
This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demo..
Engineering Enzyme-Cleavable Hybrid Click Capsules with a pH-Sheddable Coating for Intracellular Degradation
Sylvia T Gunawan, Kang Liang, Georgina K Such, Angus PR Johnston, Melissa KM Leung, Jiwei Cui, Frank Caruso
The engineering of layer-by-layer (LbL) hybrid click capsules that are responsive to biological stimuli is reported. The capsules ..
Continuous assembly of polymers via solid phase reactions
Eunhyung Nam, Jinguk Kim, Stefanie N Guntari, Helga Seyler, Qiang Fu, Edgar HH Wong, Anton Blencowe, David J Jones, Frank Caruso, Greg G Qiao
The continuous assembly of polymers in the solid state via ring-opening metathesis polymerization (ssCAPROMP) is reported as an ef..
Fluidized Bed Layer-by-Layer Microcapsule Formation
Joseph J Richardson, Darwin Teng, Mattias Bjoernmalm, Sylvia T Gunawan, Junling Guo, Jiwei Cui, George V Franks, Frank Caruso
Polymer microcapsules can be used as bioreactors and artificial cells; however, preparation methods for cell-like microcapsules ar..
Fundamental Studies of Hybrid Poly(2-(diisopropylamino)ethyl methacrylate)/Poly(N-vinylpyrrolidone) Films and Capsules
Sher Leen Ng, James P Best, Kristian Kempe, Kang Liang, Angus PR Johnston, Georgina K Such, Frank Caruso
Hybrid and multicompartment carriers are of significant interest for the development of next-generation therapeutic drug carriers...
Surface-Initiated Polymerization within Mesoporous Silica Spheres for the Modular Design of Charge-Neutral Polymer Particles
Markus Muellner, Jiwei Cui, Ka Fung Noi, Sylvia T Gunawan, Frank Caruso
We report a templating approach for the preparation of functional polymer replica particles via surface-initiated polymerization i..
In vivo imaging and tracking of individual nanodiamonds in drosophila melanogaster embryos
David A Simpson, Amelia J Thompson, Mark Kowarsky, Nida F Zeeshan, Michael SJ Barson, Liam T Hall, Yan Yan, Stefan Kaufmann, Brett C Johnson, Takeshi Ohshima, Frank Caruso, Robert E Scholten, Robert B Saint, Michael J Murray, Lloyd CL Hollenberg
In this work, we incorporate and image individual fluorescent nanodiamonds in the powerful genetic model system Drosophila melanog..
Peptide-Tunable Drug Cytotoxicity via One-Step Assembled Polymer Nanoparticles
Kang Liang, Joseph J Richardson, Hirotaka Ejima, Georgina K Such, Jiwei Cui, Frank Caruso
A novel class of nanoparticles is developed for the co-delivery of a short cell penetrating peptide and a chemotherapeutic drug to..
Endocytic pH-Triggered Degradation of Nanoengineered Multilayer Capsules
Kang Liang, Georgina K Such, Angus PR Johnston, Zhiyuan Zhu, Hirotaka Ejima, Joseph J Richardson, Jiwei Cui, Frank Caruso
The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specif..
Coordination-Driven Multistep Assembly of Metal-Polyphenol Films and Capsules
Md Arifur Rahim, Hirotaka Ejima, Kwun Lun Cho, Kristian Kempe, Markus Muellner, James P Best, Frank Caruso
We report the assembly of metal-polyphenol complex (MPC) films and capsules through the sequential deposition of iron(III) ions (F..
Nanoscale engineering of low-fouling surfaces through polydopamine immobilisation of zwitterionic peptides
Jiwei Cui, Yi Ju, Kang Liang, Hirotaka Ejima, Samuel Loercher, Katelyn T Gause, Joseph J Richardson, Frank Caruso
We report a versatile approach for the design of substrate-independent low-fouling surfaces via mussel-inspired immobilisation of ..
Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging
Damien Mertz, Christine Affolter-Zbaraszczuk, Julien Barthes, Jiwei Cui, Frank Caruso, Thomas F Baumert, Jean-Claude Voegel, Joelle Ogier, Florent Meyer
In this article, we address the design of innovative human serum albumin (HSA)-based nanoparticles loaded with silencing RNA and g..
Clickable Poly(2-oxazoline) Architectures for the Fabrication of Low-Fouling Polymer Capsules
Kristian Kempe, Sher Leen Ng, Ka Fung Noi, Markus Muellner, Sylvia T Gunawan, Frank Caruso
Hollow polymer capsules were prepared from linear as well as brushlike poly(2-oxazoline)s (POxs). Linear POxs containing alkene fu..
Differential Roles of the Protein Corona in the Cellular Uptake of Nanoporous Polymer Particles by Monocyte and Macrophage Cell Lines
Yan Yan, Katelyn T Gause, Marloes MJ Kamphuis, Ching-Seng Ang, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Edouard C Nice, Frank Caruso
Many biomolecules, mainly proteins, adsorb onto polymer particles to form a dynamic protein corona in biological environments. The..
Immersive Polymer Assembly on Immobilized Particles for Automated Capsule Preparation
Joseph J Richardson, Kang Liang, Kristian Kempe, Hirotaka Ejima, Jiwei Cui, Frank Caruso
We report a versatile approach for polymer capsule preparation using immobilized particles, which are immersed into polymer soluti..
Mechanical Characterization of Ultrasonically Synthesized Microbubble Shells by Flow Cytometry and AFM
Francesca Cavalieri, James P Best, Camilo Perez, Juan Tu, Frank Caruso, Thomas J Matula, Muthupandian Ashokkumar
The mechanical properties of the shell of ultrasonically synthesized lysozyme microbubbles, LSMBs, were evaluated by acoustic inte..
Advanced Subcompartmentalized Microreactors: Polymer Hydrogel Carriers Encapsulating Polymer Capsules and Liposomes
Leticia Hosta-Rigau, Olga Shimoni, Brigitte Stadler, Frank Caruso
The design of compartmentalized carriers for advanced drug delivery systems or artificial cells and organelles is of interest for ..
Layer-by-Layer Polymer Coating on Discrete Particles of Cubic Lyotropic Liquid Crystalline Dispersions (Cubosomes)
Chantelle D Driever, Xavier Mulet, Lynne J Waddington, Almar Postma, Helmut Thissen, Frank Caruso, Calum J Drummond
Cubic phase lyotropic liquid crystalline colloidal dispersions (cubosomes) were surface-modified with seven polyelectrolyte layers..
Assembly of Nanostructured Films with Hydrophobic Subcompartments via Continuous Assembly of Polymers
Edgar HH Wong, Martin P van Koeverden, Eunhyung Nam, Stefanie N Guntari, Steven Harris Wibowo, Anton Blencowe, Frank Caruso, Greg G Qiao
The generation of nanoscale polymer films using complex, hierarchically structured (bio)macromolecular architectures has important..
Near-Incompressible Faceted Polymer Microcapsules from Metal-Organic Framework Templates
Hirotaka Ejima, Nobuhiro Yanai, James P Best, Melinda Sindoro, Steve Granick, Frank Caruso
Faceted polymer microcapsules are prepared from metal-organic framework (MOF) templates. The MOF templates are removable under mil..
Assembly of Free-Standing Polypeptide Films via the Synergistic Combination of Hyperbranched Macroinitiators, the Grafting-From Approach, and Cross-Chain Termination
Steven Harris Wibowo, Edgar HH Wong, Adrian Sulistio, Stefanie N Guntari, Anton Blencowe, Frank Caruso, Greg G Qiao
Cross-linked polypeptide-based films are fabricated via a novel and robust method employing surface-initiated ring opening polymer..
Low-Fouling, Biospecific Films Prepared by the Continuous Assembly of Polymers
Stefanie N Guntari, Edgar HH Wong, Tor K Goh, Rona Chandrawati, Anton Blencowe, Frank Caruso, Greg G Qiao
We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a..
Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles
Jiwei Cui, Robert De Rose, James P Best, Angus PR Johnston, Sheilajen Alcantara, Kang Liang, Georgina K Such, Stephen J Kent, Frank Caruso
DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elast..
Detection of atomic spin labels in a lipid bilayer using a single-spin nanodiamond probe
Stefan Kaufmann, David A Simpson, Liam T Hall, Viktor Perunicic, Philipp Senn, Steffen Steinert, Liam P McGuinness, Brett C Johnson, Takeshi Ohshima, Frank Caruso, Joerg Wrachtrup, Robert E Scholten, Paul Mulvaney, Lloyd Hollenberg
Magnetic field fluctuations arising from fundamental spins are ubiquitous in nanoscale biology, and are a rich source of informati..
Particles on the Move: Intracellular Trafficking and Asymmetric Mitotic Partitioning of Nanoporous Polymer Particles
Yan Yan, Zon W Lai, Robert JA Goode, Jiwei Cui, Tess Bacic, Marloes MJ Kamphuis, Edouard C Nice, Frank Caruso
Nanoporous polymer particles (NPPs) prepared by mesoporous silica templating show promise as a new class of versatile drug/gene de..
Preparation of Nano- and Microcapsules by Electrophoretic Polymer Assembly
Joseph J Richardson, Hirotaka Ejima, Samuel L Loercher, Kang Liang, Philipp Senn, Jiwei Cui, Frank Caruso
Slipping into a comfortable routine: Multilayered polymer thin films were assembled on particles immobilized in agarose by electro..
Stiffness-mediated adhesion of cervical cancer cells to soft hydrogel films
James P Best, Sameen Javed, Joseph J Richardson, Kwun Lun Cho, Marloes MJ Kamphuis, Frank Caruso
We report engineered hydrogel thin-films with varying degrees of covalent crosslinking, which demonstrate enhanced HeLa cell adhes..