Identifying Neurobiological Markers of the Broader Autism Phenotype

Abstract

PUBLIC ABSTRACT Individuals with autism have difficulties with social interaction, communication, and repetitive behaviors. Finding genes for social behavior is crucial to understanding the cause of autism, which remains unknown but is presumed genetic in the majority of cases. Finding genes for complex human behaviors poses a significant challenge, however, as it requires systematic identification of disease-associated traits (endophenotypes) that are often unable to be precisely measured. The "broader autism phenotype" (BAP) provides an ideal model for investigation because it primarily involves social-relatedness difficulties that are similar to, yet milder than, those seen in autism. Cur..

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