Effectiveness Of Ghrelin Receptor Agonists To Limit The Extent Of Tissue Damage Caused By Traumatic Injury To The Central Nervous System

Grant number: 1049287 | Funding period: 2013 - 2015

Completed

Abstract

Ghrelin is a naturally occurring compound that under adverse conditions can activate specific receptors on cells around the body to enhance their survival. These receptors are also present in the spinal cord, but ghrelin doesn't enter the spinal cord. We will investigate a new group of compounds that can enter the spinal cord and activate these receptors to see if this can reduce the amount of damage that occurs after a spinal cord injury. Less tissue damage would mean less permanent disability.