Identifying the mechanisms of action of a novel 8-hydroxy quinazolinone in models of Parkinson's disease
Grant number: 1043992 | Funding period: 2013 - 2015
Completed
Abstract
By the time symptoms of Parkinson's disease (PD) appear, 60-70% of the cells in a crucial part of the brain called the substantia nigra have been destroyed and within a few years of diagnosis, most of the remaining cells have died. This project investigates the causes of this cell loss and a how a new class of compounds could interrupts the process. Success in achieving the aims of this proposal will add to our knowledge of the causes of neuronal death in PD