Understanding the role of endogenous and pharmacologic glycosaminoglycans in preventing pre-eclampsia

Grant number: 1042239 | Funding period: 2013 - 2017

Completed

Abstract

Pre-eclampsia (PE) is a serious pregnancy complication that affects the well being of the mother and baby. There is no cure for PE except for delivery of the baby. This may result in delivery much earlier than expected causing a very premature baby. This study investigates substances in the placenta that may be responsible for causing PE. If we can understand how these substances cause the problem of PE, we may be able to find better ways of treating or preventing it.

Related publications (5)

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Pregnant biglycan knockout mice have altered cardiorenal adaptations and a shorter gestational length, but do not develop a pre-eclamptic phenotype

JF Briffa, W Bevens, S Gravina, JM Said, ME Wlodek

2022-02-09

INTRODUCTION: Pre-eclampsia complicates 4.6% of pregnancies and is linked to impaired placentation; likely due to dysregulated vas..

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Decreased placental glypican expression is associated with human fetal growth restriction

T Gunatillake, A Chui, E Fitzpatrick, V Ignjatovic, P Monagle, J Whitelock, D Zanten, J Eijsink, A Borg, J Stevenson, SP Brennecke, JJHM Erwich, JM Said, P Murthi

2019-01-15

Placental mediated fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Heparan sulphate proteo..

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Antiangiogenic effects of decorin restored by unfractionated, low molecular weight, and nonanticoagulant heparins

Amy KL Chui, Tilini N Gunatillake, Vera Ignjatovic, Paul T Monagle, Padma Murthi, Shaun P Brennecke, John M Whitelock, Joanne M Said

2017-07-01

Pregnancies affected by preeclampsia (PE) or fetal growth restriction (FGR) display increases in thrombin generation and reduction..

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Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells

Amy Chui, Tilini Gunatillake, Shaun P Brennecke, Vera Ignjatovic, Paul T Monagle, John M Whitelock, Dagmar E van Zanten, Jasper Eijsink, Yao Wang, James Deane, Anthony J Borg, Janet Stevenson, Jan Jaap Erwich, Joanne M Said, Padma Murthi

2017-06-01

OBJECTIVE: Biglycan (BGN) has reduced expression in placentae from pregnancies complicated by fetal growth restriction (FGR). We u..

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Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?

A Chui, P Murthi, T Gunatillake, SP Brennecke, V Ignjatovic, PT Monagle, JM Whitelock, JM Said

2014-08-01

OBJECTIVE: Fetal growth restriction (FGR) is a key cause of adverse pregnancy outcome where maternal and fetal factors are identif..