Soluble endoglin in the pathogenesis of preeclampsia: investigation of mechanisms and the development of therapeutics

Grant number: 1048707 | Funding period: 2013 - 2015

Completed

Abstract

Preeclampsia is a severe disease of pregnancy. As the pathogenesis is poorly understood, the only treatment is for clinicians to deliver babies irrespective of gestation. We have identified MMP-14 as the molecular scissors that release soluble endoglin from placenta, a toxin centrally responsible for severe preeclampsia. In this project we aim to further investigate the mechanisms governing soluble endoglin release and to begin developing a potential therapeutic for use in the clinic.

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