Elucidating the pathogenic role of rotavirus infection in type 1 diabetes development
Grant number: 1044868 | Funding period: 2013 - 2015
Rotavirus infection is the main cause of severe diarrhoea in children, and has been implicated in accelerated progression of genetically at-risk children towards type 1 diabetes in two independent studies. My group has further discovered that rotavirus also accelerates diabetes onset in mice in a novel immunological process. In this project, we will determine the mechanism behind this disease exacerbation in the mice, to facilitate understanding of the process in children.
Related publications (4)
Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling
Jessica A Pane, Fiona E Fleming, Kate L Graham, Helen E Thomas, Thomas WH Kay, Barbara S Coulson
Rotavirus infection is associated with childhood progression to type 1 diabetes. Infection by monkey rotavirus RRV accelerates dia..
VP7 of Rhesus monkey rotavirus RRV contributes to diabetes acceleration in association with an elevated anti-rotavirus antibody response
Jessica A Pane, Vi T Dang, Gavan Holloway, Nicole L Webster, Barbara S Coulson
T cell-receptor transgenic NOD8.3 mice provide a model for spontaneous type 1 diabetes development. Infection of 5 week-old NOD8.3..
Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells
Jessica A Pane, Nicole L Webster, Barbara S Coulson
It has been proposed that rotavirus infection promotes the progression of genetically-predisposed children to type 1 diabetes, a c..
Rotavirus acceleration of murine type 1 diabetes is associated with increased MHC class I-restricted antigen presentation by B cells and elevated proinflammatory cytokine expression by T cells
Jessica A Pane, Nicole L Webster, Christel Zufferey, Barbara S Coulson
Rotavirus infection has been proposed to enhance progression towards type 1 diabetes in at-risk children. Rhesus monkey rotavirus ..