Elucidating the pathogenic role of rotavirus infection in type 1 diabetes development

Grant number: 1044868 | Funding period: 2013 - 2015

Completed

Abstract

Rotavirus infection is the main cause of severe diarrhoea in children, and has been implicated in accelerated progression of genetically at-risk children towards type 1 diabetes in two independent studies. My group has further discovered that rotavirus also accelerates diabetes onset in mice in a novel immunological process. In this project, we will determine the mechanism behind this disease exacerbation in the mice, to facilitate understanding of the process in children.

Related publications (4)

University of Melbourne Researchers