Identifying key players in the spread of antimicrobial resistance

Grant number: 1043830 | Funding period: 2013 - 2015

Completed

Abstract

Antibiotic drugs are essential to treat bacterial infections. However some bacteria have genes that allow them to resist certain drugs, which can be transferred among bacteria to create 'superbugs' that can resist nearly all the drugs we have. This project investigates the transfer of drug resistance genes between Gram negative bacteria (common agents of food poisoning, hospital infection, UTI, etc) and aims to identify the bacteria and genes most important in the spread of superbugs in Australia.

Related publications (6)

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ISMapper: Identifying insertion sequences in bacterial genomes from short read sequence data

Jane Hawkey, Mohammad Hamidian, Ryan R Wick, David J Edwards, Helen Billman-Jacobe, Ruth M Hall, Kathryn E Holt

<jats:p>Background Insertion sequences (IS) are small transposable elements, commonly found in bacterial genomes. Identifying the ..

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Dynamics of antimicrobial resistance in intestinal Escherichia coli from children in community settings in South Asia and sub-Saharan Africa

Danielle J Ingle, Myron M Levine, Karen L Kotloff, Kathryn E Holt, Roy M Robins-Browne

2018-09-01

The dynamics of antimicrobial resistance (AMR) in developing countries are poorly understood, especially in community settings, du..

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In silico serotyping of E. coli from short read data identifies limited novel O-loci but extensive diversity of O:H serotype combinations within and between pathogenic lineages

Danielle J Ingle, Mary Valcanis, Alex Kuzevski, Marija Tauschek, Michael Inouye, Tim Stinear, Myron M Levine, Roy M Robins-Browne, Kathryn E Holt

2016-07-01

The lipopolysaccharide (O) and flagellar (H) surface antigens of Escherichia coli are targets for serotyping that have traditional..

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Repeated local emergence of carbapenem-resistant Acinetobacter baumannii in a single hospital ward

Mark B Schultz, Pham Thanh Duy, Tran Do Hoan Nhu, Ryan R Wick, Danielle J Ingle, Jane Hawkey, David J Edwards, Johanna J Kenyon, Phu Huong Lan Nguyen, James I Campbell, Guy Thwaites, Thi Khanh Nhu Nguyen, Ruth M Hall, Alexandre Fournier-Level, Stephen Baker, Kathryn E Holt

2016-03-01

We recently reported a dramatic increase in the prevalence of carbapenem-resistant Acinetobacter baumannii infections in the inten..

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ISMapper: identifying transposase insertion sites in bacterial genomes from short read sequence data

Jane Hawkey, Mohammad Hamidian, Ryan R Wick, David J Edwards, Helen Billman-Jacobe, Ruth M Hall, Kathryn E Holt

2015-09-03

BACKGROUND: Insertion sequences (IS) are small transposable elements, commonly found in bacterial genomes. Identifying the locatio..

Scholarly works icon

SRST2: Rapid genomic surveillance for public health and hospital microbiology labs

Michael Inouye, Harriet Dashnow, Lesley-Ann Raven, Mark B Schultz, Bernard J Pope, Takehiro Tomita, Justin Zobel, Kathryn E Holt

2014-11-20

Rapid molecular typing of bacterial pathogens is critical for public health epidemiology, surveillance and infection control, yet ..

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