A twin study of breast cancer and epigenetics

Grant number: 1050561 | Funding period: 2013 - 2016

Completed

Abstract

We will conduct a study of more than 500 Australian female twin pairs in which one or both have had breast cancer. We will also study measured and unmeasured genetic and environmental causes of risk factors.

Related publications (10)

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Residential surrounding greenness and DNA methylation: An epigenome-wide association study.

Rongbin Xu, Shuai Li, Shanshan Li, Ee Ming Wong, Melissa C Southey, John L Hopper, Michael J Abramson, Yuming Guo

2021-04-13

BACKGROUND: DNA methylation is a potential biological mechanism through which residential greenness affects health, but little is ..

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Inference about causation from examination of familial confounding (ICE FALCON): a model for assessing causation analogous to Mendelian randomization

Shuai Li, Minh Bui, John L Hopper

2020-08-01

BACKGROUND: We developed a method to make Inference about Causation from Examination of FAmiliaL CONfounding (ICE FALCON) using ob..

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DNA methylation-based biological age, genome-wide average DNA methylation, and conventional breast cancer risk factors

Minyuan Chen, Ee Ming Wong, Tuong L Nguyen, Gillian S Dite, Jennifer Stone, Pierre-Antoine Dugue, Graham G Giles, Melissa C Southey, Roger L Milne, John L Hopper, Shuai Li

2019-10-21

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Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures

Shuai Li, Pierre-Antoine Dugue, Laura Baglietto, Gianluca Severi, Ee Ming Wong, Tuong L Nguyen, Jennifer Stone, Dallas R English, Melissa C Southey, Graham G Giles, John L Hopper, Roger L Milne

2019-10-01

Age- and body mass index (BMI)-adjusted mammographic density is one of the strongest breast cancer risk factors. DNA methylation i..

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Inference about causation between body mass index and DNA methylation in blood from a twin family study

Shuai Li, Ee Ming Wong, Minh Bui, Tuong L Nguyen, Ji-Hoon Eric Joo, Jennifer Stone, Gillian S Dite, Pierre-Antoine Dugue, Roger L Milne, Graham G Giles, Richard Saffery, Melissa C Southey, John L Hopper

2019-02-01

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Genome-wide average DNA methylation is determined in utero

Shuai Li, Ee Ming Wong, Pierre-Antoine Dugue, Allan F McRae, Eunae Kim, Ji-Hoon Eric Joo, Tuong L Nguyen, Jennifer Stone, Gillian S Dite, Nicola J Armstrong, Karen A Mather, Anbupalam Thalamuthu, Margaret J Wright, David Ames, Roger L Milne, Jeffrey M Craig, Richard Saffery, Grant W Montgomery, Yun-Mi Song, Joohon Sung

2018-06-01

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Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study

Shuai Li, Ee Ming Wong, Minh Bui, Tuong L Nguyen, Ji-Hoon Eric Joo, Jennifer Stone, Gillian S Dite, Graham G Giles, Richard Saffery, Melissa C Southey, John L Hopper

2018-02-09

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Twin birth changes DNA methylation of subsequent siblings

Shuai Li, Eunae Kim, Ee Ming Wong, Ji-Hoon Eric Joo, Tuong L Nguyen, Jennifer Stone, Yun-Mi Song, Louisa B Flander, Richard Saffery, Graham G Giles, Melissa C Southey, Joohon Sung, John L Hopper

2017-08-16

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Causes of blood methylomic variation for middle-aged women measured by the HumanMethylation450 array

Shuai Li, Ee Ming Wong, Tuong L Nguyen, Ji-Hoon Eric Joo, Jennifer Stone, Gillian S Dite, Graham G Giles, Richard Saffery, Melissa C Southey, John L Hopper

2017-01-01

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Genetic and Environmental Causes of Variation in the Difference Between Biological Age Based on DNA Methylation and Chronological Age for Middle-Aged Women

Shuai Li, Ee Ming Wong, JiHoon E Joo, Chol-Hee Jung, Jessica Chung, Carmel Apicella, Jennifer Stone, Gillian S Dite, Graham G Giles, Melissa C Southey, John L Hopper

2015-12-01