Modeling early intervention in schizophrenia: role of BDNF
Grant number: 1044777 | Funding period: 2013 - 2015
Schizophrenia is a major burden on sufferers and society at large. Currently available treatments are only partially effective and often associated with significant side effects. This project will explore the neurobiological mechanisms of early preventative treatments in schizophrenia using a 'two hit' developmental mouse model. The results could have important clinical implcations for preventative treatment options.
Related publications (3)
Sex-Dependent Effects of Environmental Enrichment on Spatial Memory and Brain-Derived Neurotrophic Factor (BDNF) Signaling in a Developmental "Two-Hit" Mouse Model Combining BDNF Haploinsufficiency and Chronic Glucocorticoid Stimulation
Adrienne M Grech, Udani Ratnayake, Anthony J Hannan, Maarten van den Buuse, Rachel A Hill
Neurodevelopmental disorders are thought to be caused by a combination of adverse genetic and environmental insults. The "two-hit"..
Brain-derived neurotrophic factor haploinsufficiency impairs high-frequency cortical oscillations in mice
Nigel C Jones, Matthew Hudson, Joshua Foreman, Gil Rind, Rachel Hill, Elizabeth E Manning, Maarten van den Buuse
Schizophrenia is a complex psychiatric disorder with a heterogeneous aetiology involving genetic and environmental factors. Defici..
Dopaminergic activity and behaviour in SOCS2 transgenic mice: Revealing a potential drug target for schizophrenia
Udani Ratnayake, Harleen S Basrai, Ann M Turnley, Maarten van den Buuse
Alterations in immune function have been implicated in the aetiopathogenesis of schizophrenia. Specifically, the induction of infl..