Modeling early intervention in schizophrenia: role of BDNF
Grant number: 1044777 | Funding period: 2013 - 2015
Schizophrenia is a major burden on sufferers and society at large. Currently available treatments are only partially effective and often associated with significant side effects. This project will explore the neurobiological mechanisms of early preventative treatments in schizophrenia using a 'two hit' developmental mouse model. The results could have important clinical implcations for preventative treatment options.
Related publications (3)
Sex-Dependent Effects of Environmental Enrichment on Spatial Memory and Brain-Derived Neurotrophic Factor (BDNF) Signaling in a Developmental "Two-Hit" Mouse Model Combining BDNF Haploinsufficiency and Chronic Glucocorticoid Stimulation
Adrienne M Grech, Udani Ratnayake, Anthony J Hannan, Maarten van den Buuse, Rachel A Hill