Elucidating the role of claudin-2 in tumour initiation and metastasis development from colorectal cancer: consequence for tumour relapse
Grant number: 1049561 | Funding period: 2013 - 2016
Mortality from colorectal cancer is often due to the development of metastases. Cancer stem cells (CSC) are suspected to provide a major drive for metastasis development, to resist current therapies, and to initiate tumour relapse. Yet, little is known about mechanisms that control CSC behaviour. Our project investigates the role of claudin-2, a cell adhesion protein that is strongly overexpressed in colorectal cancer, in the regulation of CSCs, metastasis development and tumour relapse.
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Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells
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Posttreatment recurrence of colorectal cancer, the third most lethal cancer worldwide, is often driven by a subpopulation of cance..
Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture
Fanny Grillet, Elsa Bayet, Olivia Villeronce, Luke Zappia, Ebba Louise Lagerqvist, Sebastian Lunke, Emmanuelle Charafe-Jauffret, Kym Pham, Christina Molck, Nathalie Rolland, Jean Francois Bourgaux, Michel Prudhomme, Claire Philippe, Sophie Bravo, Jean Christophe Boyer, Lucile Canterel-Thouennon, Graham Roy Taylor, Arthur Hsu, Jean Marc Pascussi, Frederic Hollande
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The A(2b) adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism
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Progression of castration-resistant tumors is frequent in prostate cancer. Current systemic treatments for castration-resistant pr..
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Subpopulations of cancer stem-like cells (CSC) are thought to drive tumor progression and posttreatment recurrence in multiple sol..
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Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment
Corina Kim-Fuchs, Caroline P Le, Matthew A Pimentel, David Shackleford, Davide Ferrari, Eliane Angst, Frederic Hollande, Erica K Sloan
Pancreatic cancer cells intimately interact with a complex microenvironment that influences pancreatic cancer progression. The pan..
Lymphovascular and neural regulation of metastasis: shared tumour signalling pathways and novel therapeutic approaches.
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The progression of cancer is supported by a wide variety of non-neoplastic cell types which make up the tumour stroma, including i..