The Role of TGFB1 in the Pathophysiology of Late Stage Schizophrenia

Grant number: 1048544 | Funding period: 2013 - 2015

Completed

Abstract

Schizophrenia is triggered in people with a genetic predisposition by as yet unknown environmental factors. Having shown that changes in gene expression in the brains of people with schizophrenia vary as the disease progresses, this application seeks to understand the changes in a pathway regulated by transforming growth factor ?1 that occur late in the progression of the illness. Understanding the changes in this important pathway could affect how people with schizophrenia are treated as their disorder progresses.