Cytokine regulation of inflammatory pain
Grant number: 1043147 | Funding period: 2013 - 2015
What drives the pain associated with inflammation is unknown as is the relationship between pain and the extent of tissue damage associated with disease, for example, arthritis. Our laboratory has shown that a particular protein is a key mediator of inflammatory pain. The project is to understand how this particular protein promotes pain, including how it sensitzes neurons.
Related publications (8)
Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain
Damini Tewari, Andrew D Cook, Ming-Chin Lee, Anne D Christensen, Andrew Croxford, Burkhard Becher, Daniel Poole, Pradeep Rajasekhar, Nigel Bunnett, Julia E Smith, John A Hamilton, Stephen B McMahon
The interaction between the immune system and the nervous system has been at the center of multiple research studies in recent yea..
GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation
Ming-Chin Lee, Derek C Lacey, Andrew J Fleetwood, Adrian Achuthan, John A Hamilton, Andrew D Cook
Studies have demonstrated the importance of a GM-CSF→IFN regulatory factor 4 (IRF4)→CCL17 pathway, first identified in monocytes/m..
CSF-1 in Inflammatory and Arthritic Pain Development
Reem Saleh, Ming-Chin Lee, Stella H Khiew, Cynthia Louis, Andrew J Fleetwood, Adrian Achuthan, Irmgard Foerster, Andrew D Cook, John A Hamilton
Pain is one of the most debilitating symptoms in many diseases for which there is inadequate management and understanding. CSF-1, ..
Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages
Amy T Hsu, Tanya J Lupancu, Ming-Chin Lee, Andrew J Fleetwood, Andrew D Cook, John A Hamilton, Adrian Achuthan
Interleukin 4 (IL4) is generally viewed as a Th2 cytokine capable of polarizing macrophages into an anti-inflammatory phenotype, w..
CCL17 blockade as a therapy for osteoarthritis pain and disease
Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Irmgard Foerster, John A Hamilton, Andrew D Cook
BACKGROUND: Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of infla..
TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17
Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Anne D Christensen, Adrian Achuthan, Andrew J Fleetwood, Derek C Lacey, Julia E Smith, Irmgard Foerster, John A Hamilton
TNF and granulocyte macrophage-colony stimulating factor (GM-CSF) have proinflammatory activity and both contribute, for example, ..
Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity
Adrian Achuthan, Ahmad SM Aslam, Nguyen Quyen, Pui-Yeng Lam, Andrew J Fleetwood, Ashlee T Frye, Cynthia Louis, Ming-Chin Lee, Julia E Smith, Andrew D Cook, Moshe Olshansky, Stephen J Turner, John A Hamilton
Glucocorticoids (GCs) are potent anti-inflammatory drugs whose mode of action is complex and still debatable. One likely cellular ..
Granulocyte macrophage colony-stimulating factor induces CCL17 pro uction via IRF4 to mediate inflammation
Adrian Achuthan, Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Melody WN Chang, Cynthia Louis, Andrew J Fleetwood, Derek C Lacey, Anne D Christensen, Ashlee T Frye, Pui Yeng Lam, Hitoshi Kusano, Koji Nomura, Nancy Steiner, Irmgard Foerster, Stephen L Nutt, Moshe Olshansky, Stephen J Turner, John A Hamilton
Data from preclinical and clinical studies have demonstrated that granulocyte macrophage colony-stimulating factor (GM-CSF) can fu..